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Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome.

Liang V, Ullrich M, Lam H, Chew YL, Banister S, Song X, Zaw T, Kassiou M, Götz J, Nicholas HR.

Cell Mol Life Sci. 2014 Sep;71(17):3339-61. doi: 10.1007/s00018-014-1558-7. Epub 2014 Jan 24.


Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans.

Ullrich M, Liang V, Chew YL, Banister S, Song X, Zaw T, Lam H, Berber S, Kassiou M, Nicholas HR, Götz J.

Nat Protoc. 2014 Sep;9(9):2237-55. doi: 10.1038/nprot.2014.150. Epub 2014 Aug 28. Erratum in: Nat Protoc. 2014 Dec;9(12):2903.


A genetic screening strategy identifies novel regulators of the proteostasis network.

Silva MC, Fox S, Beam M, Thakkar H, Amaral MD, Morimoto RI.

PLoS Genet. 2011 Dec;7(12):e1002438. doi: 10.1371/journal.pgen.1002438. Epub 2011 Dec 29.


The nascent polypeptide-associated complex is a key regulator of proteostasis.

Kirstein-Miles J, Scior A, Deuerling E, Morimoto RI.

EMBO J. 2013 May 15;32(10):1451-68. doi: 10.1038/emboj.2013.87. Epub 2013 Apr 19.


Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032.


Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.

Ben-Zvi A, Miller EA, Morimoto RI.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14914-9. doi: 10.1073/pnas.0902882106. Epub 2009 Aug 24.


Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons.

Prahlad V, Cornelius T, Morimoto RI.

Science. 2008 May 9;320(5877):811-4. doi: 10.1126/science.1156093.


Regulation of aging and age-related disease by DAF-16 and heat-shock factor.

Hsu AL, Murphy CT, Kenyon C.

Science. 2003 May 16;300(5622):1142-5. Erratum in: Science. 2003 Jun 27;300(5628):2033.


Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood.

Shemesh N, Shai N, Ben-Zvi A.

Aging Cell. 2013 Oct;12(5):814-22. doi: 10.1111/acel.12110. Epub 2013 Jun 28.


Creating a path from the heat shock response to therapeutics of protein-folding diseases: an interview with Rick Morimoto.

Morimoto R.

Dis Model Mech. 2014 Jan;7(1):5-8. doi: 10.1242/dmm.014753. No abstract available.


Metabolome and proteome changes with aging in Caenorhabditis elegans.

Copes N, Edwards C, Chaput D, Saifee M, Barjuca I, Nelson D, Paraggio A, Saad P, Lipps D, Stevens SM Jr, Bradshaw PC.

Exp Gerontol. 2015 Dec;72:67-84. doi: 10.1016/j.exger.2015.09.013. Epub 2015 Sep 21.


Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis.

Lindquist SL, Kelly JW.

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a004507. doi: 10.1101/cshperspect.a004507. Review.


A neuronal GPCR is critical for the induction of the heat shock response in the nematode C. elegans.

Maman M, Carvalhal Marques F, Volovik Y, Dubnikov T, Bejerano-Sagie M, Cohen E.

J Neurosci. 2013 Apr 3;33(14):6102-11. doi: 10.1523/JNEUROSCI.4023-12.2013.


HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans.

Kern A, Ackermann B, Clement AM, Duerk H, Behl C.

PLoS One. 2010 Jan 5;5(1):e8568. doi: 10.1371/journal.pone.0008568.


Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.

Raynes R, Leckey BD Jr, Nguyen K, Westerheide SD.

J Biol Chem. 2012 Aug 17;287(34):29045-53. doi: 10.1074/jbc.M112.353714. Epub 2012 Jul 9.


Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset.

Feldman N, Kosolapov L, Ben-Zvi A.

PLoS One. 2014 Jan 21;9(1):e85964. doi: 10.1371/journal.pone.0085964. eCollection 2014.


High transcript levels of heat-shock genes are associated with shorter lifespan of Caenorhabditis elegans.

Manière X, Krisko A, Pellay FX, Di Meglio JM, Hersen P, Matic I.

Exp Gerontol. 2014 Dec;60:12-7. doi: 10.1016/j.exger.2014.09.005. Epub 2014 Sep 16.


Heat shock factor 1 prevents the reduction in thrashing due to heat shock in Caenorhabditis elegans.

Furuhashi T, Sakamoto K.

Biochem Biophys Res Commun. 2015 Jul 3;462(3):190-4. doi: 10.1016/j.bbrc.2015.04.086. Epub 2015 Apr 29.


BONCAT: metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes.

Landgraf P, Antileo ER, Schuman EM, Dieterich DC.

Methods Mol Biol. 2015;1266:199-215. doi: 10.1007/978-1-4939-2272-7_14.


Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses.

van Oosten-Hawle P, Morimoto RI.

J Exp Biol. 2014 Jan 1;217(Pt 1):129-36. doi: 10.1242/jeb.091249. Review.

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