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Items: 1 to 20 of 114

1.

3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.

Ponnapakam AP, Liu J, Bhinge KN, Drew BA, Wang TL, Antoon JW, Nguyen TT, Dupart PS, Wang Y, Zhao M, Liu YY, Foroozesh M, Beckman BS.

Bioorg Med Chem. 2014 Feb 15;22(4):1412-20. doi: 10.1016/j.bmc.2013.12.065. Epub 2014 Jan 8.

2.

Novel ceramide analogs as potential chemotherapeutic agents in breast cancer.

Struckhoff AP, Bittman R, Burow ME, Clejan S, Elliott S, Hammond T, Tang Y, Beckman BS.

J Pharmacol Exp Ther. 2004 May;309(2):523-32. Epub 2004 Jan 23.

3.

Ceramide glycosylation potentiates cellular multidrug resistance.

Liu YY, Han TY, Giuliano AE, Cabot MC.

FASEB J. 2001 Mar;15(3):719-30.

PMID:
11259390
4.

P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells.

Chapman JV, Gouazé-Andersson V, Karimi R, Messner MC, Cabot MC.

Exp Cell Res. 2011 Jul 15;317(12):1736-45. doi: 10.1016/j.yexcr.2011.03.004. Epub 2011 Mar 21.

5.

Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.

Antoon JW, Liu J, Gestaut MM, Burow ME, Beckman BS, Foroozesh M.

J Med Chem. 2009 Sep 24;52(18):5748-52. doi: 10.1021/jm9009668.

PMID:
19694470
6.

Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics.

Antoon JW, Liu J, Ponnapakkam AP, Gestaut MM, Foroozesh M, Beckman BS.

Cancer Chemother Pharmacol. 2010 May;65(6):1191-5. doi: 10.1007/s00280-009-1233-0. Epub 2010 Feb 14.

PMID:
20155475
8.

Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells.

Uchida Y, Itoh M, Taguchi Y, Yamaoka S, Umehara H, Ichikawa S, Hirabayashi Y, Holleran WM, Okazaki T.

Cancer Res. 2004 Sep 1;64(17):6271-9.

9.

Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.

Itoh M, Kitano T, Watanabe M, Kondo T, Yabu T, Taguchi Y, Iwai K, Tashima M, Uchiyama T, Okazaki T.

Clin Cancer Res. 2003 Jan;9(1):415-23.

10.

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation.

Baran Y, Bielawski J, Gunduz U, Ogretmen B.

J Cancer Res Clin Oncol. 2011 Oct;137(10):1535-44. doi: 10.1007/s00432-011-1016-y. Epub 2011 Aug 11.

PMID:
21833718
11.

Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation.

Shakor AB, Atia M, Ismail IA, Alshehri A, El-Refaey H, Kwiatkowska K, Sobota A.

Biochim Biophys Acta. 2014 Dec;1841(12):1672-82.

PMID:
25240837
12.

The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs.

Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T.

FASEB J. 2003 Jun;17(9):1144-6. Epub 2003 Apr 8.

PMID:
12692077
13.

Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.

Gouazé V, Yu JY, Bleicher RJ, Han TY, Liu YY, Wang H, Gottesman MM, Bitterman A, Giuliano AE, Cabot MC.

Mol Cancer Ther. 2004 May;3(5):633-9.

14.

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.

Liu YY, Gupta V, Patwardhan GA, Bhinge K, Zhao Y, Bao J, Mehendale H, Cabot MC, Li YT, Jazwinski SM.

Mol Cancer. 2010 Jun 11;9:145. doi: 10.1186/1476-4598-9-145.

15.

Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.

Gouazé-Andersson V, Yu JY, Kreitenberg AJ, Bielawska A, Giuliano AE, Cabot MC.

Biochim Biophys Acta. 2007 Dec;1771(12):1407-17. Epub 2007 Nov 9.

16.

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.

Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, Ogretmen B, Cabot MC, Shah GV, Sylvester PW, Jazwinski SM, Liu YY.

PLoS One. 2009 Sep 9;4(9):e6938. doi: 10.1371/journal.pone.0006938.

17.

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance.

Liu YY, Han TY, Giuliano AE, Hansen N, Cabot MC.

J Biol Chem. 2000 Mar 10;275(10):7138-43.

18.

Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells.

Tyler A, Johansson A, Karlsson T, Gudey SK, Brännström T, Grankvist K, Behnam-Motlagh P.

Exp Cell Res. 2015 Aug 1;336(1):23-32. doi: 10.1016/j.yexcr.2015.05.012. Epub 2015 May 22.

19.

Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared to normal breast epithelial cells.

Crawford KW, Bittman R, Chun J, Byun HS, Bowen WD.

Cell Mol Biol (Noisy-le-grand). 2003 Nov;49(7):1017-23.

PMID:
14682383
20.

A review of ceramide analogs as potential anticancer agents.

Liu J, Beckman BS, Foroozesh M.

Future Med Chem. 2013 Aug;5(12):1405-21. doi: 10.4155/fmc.13.107. Review.

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