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Items: 1 to 20 of 81

1.

Hedgehog Pathway in Pediatric Cancers: They're Not Just for Brain Tumors Anymore.

Macdonald TJ.

Am Soc Clin Oncol Educ Book. 2012:605-9. doi: 10.14694/EdBook_AM.2012.32.605.

2.

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.

Palle K, Mani C, Tripathi K, Athar M.

Cancers (Basel). 2015 Nov 27;7(4):2330-51. doi: 10.3390/cancers7040894. Review.

3.

Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.

Lim CB, Prêle CM, Cheah HM, Cheng YY, Klebe S, Reid G, Watkins DN, Baltic S, Thompson PJ, Mutsaers SE.

PLoS One. 2013 Jun 24;8(6):e66685. doi: 10.1371/journal.pone.0066685.

4.

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.

Pressey JG, Anderson JR, Crossman DK, Lynch JC, Barr FG.

Pediatr Blood Cancer. 2011 Dec 1;57(6):930-8. doi: 10.1002/pbc.23174.

5.

Hedgehog signaling pathway and cancer therapeutics: progress to date.

Ruch JM, Kim EJ.

Drugs. 2013 May;73(7):613-23. doi: 10.1007/s40265-013-0045-z. Review.

PMID:
23605693
6.

MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.

Filocamo G, Brunetti M, Colaceci F, Sasso R, Tanori M, Pasquali E, Alfonsi R, Mancuso M, Saran A, Lahm A, Di Marcotullio L, Steinkühler C, Pazzaglia S.

Mol Cancer Ther. 2016 Jun;15(6):1177-89. doi: 10.1158/1535-7163.MCT-15-0371.

PMID:
26960983
7.

Targeting the Hedgehog pathway in cancer.

Gupta S, Takebe N, Lorusso P.

Ther Adv Med Oncol. 2010 Jul;2(4):237-50. doi: 10.1177/1758834010366430.

8.

Hedgehog pathway as a drug target: Smoothened inhibitors in development.

Lin TL, Matsui W.

Onco Targets Ther. 2012;5:47-58. doi: 10.2147/OTT.S21957.

9.

Small-molecule antagonists of Gli function.

Ardecky R, Magnuson GK, Zou J, Ganji SR, Brown B, Ngo T, Lee J, Zeng FY, Sun Q, Stonich D, Salaniwal S, Sakata T, Rack PG, Casabar JKT, Mangravita-Novo A, Smith LH, Sergienko E, Chung TDY, Pinkerton AB, Pass I, Chen JK.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2014 May 13].

10.

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.

Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.

Cancers (Basel). 2016 Feb 15;8(2). pii: E22. doi: 10.3390/cancers8020022. Review.

11.

Gorlin syndrome (nevoid basal cell carcinoma syndrome): update and literature review.

Fujii K, Miyashita T.

Pediatr Int. 2014 Oct;56(5):667-74. doi: 10.1111/ped.12461. Review.

PMID:
25131638
12.

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

Tostar U, Toftgård R, Zaphiropoulos PG, Shimokawa T.

Genes Cancer. 2010 Sep;1(9):941-51. doi: 10.1177/1947601910385449.

13.

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

Chaudary N, Pintilie M, Hedley D, Fyles AW, Milosevic M, Clarke B, Hill RP, Mackay H.

Cancer. 2012 Jun 15;118(12):3105-15. doi: 10.1002/cncr.26635.

14.

Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy.

Di Magno L, Coni S, Di Marcotullio L, Canettieri G.

Biochim Biophys Acta. 2015 Aug;1856(1):62-72. doi: 10.1016/j.bbcan.2015.06.003. Review.

PMID:
26080084
15.

Hedgehog inhibition as an anti-cancer strategy.

Raju GP, Pham D.

Vitam Horm. 2012;88:507-22. doi: 10.1016/B978-0-12-394622-5.00023-7. Review.

PMID:
22391319
16.

Sonic hedgehog signaling in Basal cell nevus syndrome.

Athar M, Li C, Kim AL, Spiegelman VS, Bickers DR.

Cancer Res. 2014 Sep 15;74(18):4967-75. doi: 10.1158/0008-5472.CAN-14-1666. Review.

17.

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma.

Cucchi D, Occhione MA, Gulino A, De Smaele E.

J Exp Pharmacol. 2012 Dec 14;4:173-85. doi: 10.2147/JEP.S28553. Review.

18.

Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.

Bhattarai D, Jung JH, Han S, Lee H, Oh SJ, Ko HW, Lee K.

Eur J Med Chem. 2017 Jan 5;125:1036-1050. doi: 10.1016/j.ejmech.2016.10.040.

PMID:
27810591
19.

CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway.

Chen J, Lv H, Hu J, Ji M, Xue N, Li C, Ma S, Zhou Q, Lin B, Li Y, Yu S, Chen X.

Cancer Lett. 2016 Oct 28;381(2):391-403. doi: 10.1016/j.canlet.2016.07.030.

PMID:
27495899
20.

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells.

Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B, Houghton JA.

PLoS One. 2013 Sep 25;8(9):e75253. doi: 10.1371/journal.pone.0075253.

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