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Items: 1 to 20 of 93

1.

The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ.

Mol Cell Biol. 2014 Apr;34(7):1262-70. doi: 10.1128/MCB.01140-13. Epub 2014 Jan 21.

2.

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.

Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N.

Mol Cell Biol. 2015 Nov 2;36(2):285-94. doi: 10.1128/MCB.00890-15.

3.

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.

Stevenson J, Luu W, Kristiana I, Brown AJ.

Biochem J. 2014 Aug 1;461(3):435-42. doi: 10.1042/BJ20131404.

PMID:
24840124
4.

Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.

Gill S, Stevenson J, Kristiana I, Brown AJ.

Cell Metab. 2011 Mar 2;13(3):260-73. doi: 10.1016/j.cmet.2011.01.015.

5.

The UPS and downs of cholesterol homeostasis.

Sharpe LJ, Cook EC, Zelcer N, Brown AJ.

Trends Biochem Sci. 2014 Nov;39(11):527-35. doi: 10.1016/j.tibs.2014.08.008. Epub 2014 Sep 11. Review.

PMID:
25220377
6.

Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6.

Nakamura N, Harada K, Kato M, Hirose S.

Exp Cell Res. 2014 Oct 15;328(1):207-16. doi: 10.1016/j.yexcr.2014.07.025. Epub 2014 Aug 1.

PMID:
25088257
7.

Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).

Sharpe LJ, Brown AJ.

J Biol Chem. 2013 Jun 28;288(26):18707-15. doi: 10.1074/jbc.R113.479808. Epub 2013 May 21. Review.

8.

The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis.

Doblas VG, Amorim-Silva V, Posé D, Rosado A, Esteban A, Arró M, Azevedo H, Bombarely A, Borsani O, Valpuesta V, Ferrer A, Tavares RM, Botella MA.

Plant Cell. 2013 Feb;25(2):728-43. doi: 10.1105/tpc.112.108696. Epub 2013 Feb 12.

9.

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.

Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P.

Elife. 2013 Jul 23;2:e00953. doi: 10.7554/eLife.00953.

10.

Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells.

Hidaka Y, Hotta H, Nagata Y, Iwasawa Y, Horie M, Kamei T.

J Biol Chem. 1991 Jul 15;266(20):13171-7.

12.

Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.

Mokashi V, Singh DK, Porter TD.

Arch Biochem Biophys. 2005 Jan 15;433(2):474-80.

PMID:
15581604
13.

Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR.

Sharpe LJ, Howe V, Prabhu AV, Luu W, Brown AJ.

J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S154-6. doi: 10.3177/jnsv.61.S154. Review.

14.
15.

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

Howe V, Chua NK, Stevenson J, Brown AJ.

J Biol Chem. 2015 Nov 13;290(46):27533-44. doi: 10.1074/jbc.M115.675181. Epub 2015 Oct 3.

16.

Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase.

Cohen LH, van Vliet A, Roodenburg L, Jansen LM, Griffioen M.

Biochem Pharmacol. 1993 Jun 9;45(11):2203-8. Erratum in: Biochem Pharmacol 1993 Sep 14;46(6):1101.

PMID:
8517861
17.

Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.

Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Lévy E, Mitchell GA, Tremblay A.

FASEB J. 2014 Apr;28(4):1910-23. doi: 10.1096/fj.13-240168. Epub 2013 Dec 26.

18.

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.

Honsho M, Abe Y, Fujiki Y.

J Biol Chem. 2015 Nov 27;290(48):28822-33. doi: 10.1074/jbc.M115.656983. Epub 2015 Oct 13.

19.
20.

Protein turnover regulated by cholesterol.

Kim MJ, Jessup W.

Curr Opin Lipidol. 2012 Feb;23(1):76-7. doi: 10.1097/MOL.0b013e32834f42b3. No abstract available.

PMID:
22241328

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