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Nrf1 to the rescue.

Ye J.

Elife. 2014;3:e02062. doi: 10.7554/eLife.02062.


p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan SK, den Besten W, Deshaies RJ.

Elife. 2014;3:e01856. doi: 10.7554/eLife.01856.


Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.

Sha Z, Goldberg AL.

Curr Biol. 2014 Jul 21;24(14):1573-83. doi: 10.1016/j.cub.2014.06.004.


Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.

Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.

Mol Cell Biol. 2011 Nov;31(22):4500-12. doi: 10.1128/MCB.05663-11.


Limited proteolysis: DisRUPting proteasomal inhibition.

Hoppe T.

Curr Biol. 2014 Aug 4;24(15):R693-5. doi: 10.1016/j.cub.2014.06.056.


Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.

Auner HW, Moody AM, Ward TH, Kraus M, Milan E, May P, Chaidos A, Driessen C, Cenci S, Dazzi F, Rahemtulla A, Apperley JF, Karadimitris A, Dillon N.

PLoS One. 2013 Sep 17;8(9):e74415. doi: 10.1371/journal.pone.0074415.


Stalled proteasomes are directly relieved by P97 recruitment.

Isakov E, Stanhill A.

J Biol Chem. 2011 Sep 2;286(35):30274-83. doi: 10.1074/jbc.M111.240309.


The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.

Chepelev NL, Bennitz JD, Huang T, McBride S, Willmore WG.

PLoS One. 2011;6(12):e29167. doi: 10.1371/journal.pone.0029167.


A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level.

Balasubramanian S, Kanade S, Han B, Eckert RL.

J Biol Chem. 2012 Oct 19;287(43):36179-89. doi: 10.1074/jbc.M112.359281.


Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.

Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ.

Mol Cell. 2010 Apr 9;38(1):17-28. doi: 10.1016/j.molcel.2010.02.029.


VCP - the missing link in protein degradation?

Wojcik C.

Trends Cell Biol. 2002 May;12(5):212. No abstract available.


Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.

Lim PJ, Danner R, Liang J, Doong H, Harman C, Srinivasan D, Rothenberg C, Wang H, Ye Y, Fang S, Monteiro MJ.

J Cell Biol. 2009 Oct 19;187(2):201-17. doi: 10.1083/jcb.200903024.


Ubiquitin receptors and ERAD: a network of pathways to the proteasome.

Raasi S, Wolf DH.

Semin Cell Dev Biol. 2007 Dec;18(6):780-91. Review.


A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

Lipson C, Alalouf G, Bajorek M, Rabinovich E, Atir-Lande A, Glickman M, Bar-Nun S.

J Biol Chem. 2008 Mar 14;283(11):7166-75. doi: 10.1074/jbc.M705893200.

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