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Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum.

Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, Grayson DR.

Transl Psychiatry. 2014 Jan 21;4:e349. doi: 10.1038/tp.2013.123.


DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A.

Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2.


Effects of melatonin on prenatal dexamethasone-induced epigenetic alterations in hippocampal morphology and reelin and glutamic acid decarboxylase 67 levels.

Lui CC, Hsu MH, Kuo HC, Chen CC, Sheen JM, Yu HR, Tiao MM, Tain YL, Chang KA, Huang LT.

Dev Neurosci. 2015;37(2):105-14. doi: 10.1159/000368768. Epub 2015 Feb 25.


Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters.

Dong E, Guidotti A, Grayson DR, Costa E.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4676-81. Epub 2007 Mar 7.


Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.

Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12578-83. Epub 2005 Aug 19.


The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Kundakovic M, Chen Y, Guidotti A, Grayson DR.

Mol Pharmacol. 2009 Feb;75(2):342-54. doi: 10.1124/mol.108.051763. Epub 2008 Nov 24.


Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.

James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP.

Transl Psychiatry. 2014 Oct 7;4:e460. doi: 10.1038/tp.2014.87.


DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.

Kundakovic M, Chen Y, Costa E, Grayson DR.

Mol Pharmacol. 2007 Mar;71(3):644-53. Epub 2006 Oct 25.


Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation.

Dong E, Grayson DR, Guidotti A, Costa E.

Epigenomics. 2009 Oct;1(1):201-11. doi: 10.2217/epi.09.2.


Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A.

Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.


Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice.

Zhou Q, Obana EA, Radomski KL, Sukumar G, Wynder C, Dalgard CL, Doughty ML.

Mol Biol Cell. 2016 Feb 15;27(4):627-39. doi: 10.1091/mbc.E15-07-0513. Epub 2016 Jan 6.


Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala.

Kigar SL, Chang L, Auger AP.

Brain Behav Immun. 2015 May;46:60-9. doi: 10.1016/j.bbi.2015.02.018. Epub 2015 Feb 26.


Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report.

Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, Thiagalingam S, Tsuang MT.

Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):60-6.


Reelin gene variants and risk of autism spectrum disorders: an integrated meta-analysis.

Wang Z, Hong Y, Zou L, Zhong R, Zhu B, Shen N, Chen W, Lou J, Ke J, Zhang T, Wang W, Miao X.

Am J Med Genet B Neuropsychiatr Genet. 2014 Mar;165B(2):192-200. doi: 10.1002/ajmg.b.32222. Epub 2014 Jan 22.


Epigenetic factors and autism spectrum disorders.

Flashner BM, Russo ME, Boileau JE, Leong DW, Gallicano GI.

Neuromolecular Med. 2013 Jun;15(2):339-50. doi: 10.1007/s12017-013-8222-5. Epub 2013 Mar 7. Review.


The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.

Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP.

Pharmacol Ther. 2006 Jul;111(1):272-86. Epub 2006 Mar 30. Review.


Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.

Dong E, Nelson M, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13614-9. doi: 10.1073/pnas.0805493105. Epub 2008 Aug 29.


Epigenetic aberration of the human REELIN gene in psychiatric disorders.

Tamura Y, Kunugi H, Ohashi J, Hohjoh H.

Mol Psychiatry. 2007 Jun;12(6):519, 593-600. Epub 2007 Feb 20.


Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study.

da Silva VA, Dantas Mde S, Silva LA, Carneiro JG, Schamber-Reis BL.

Biomed Res Int. 2015;2015:286369. doi: 10.1155/2015/286369. Epub 2015 Oct 7.

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