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Items: 1 to 20 of 101

1.

Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.

Bruno A, Lembo F, Novellino E, Stornaiuolo M, Marinelli L.

Sci Rep. 2014 Jan 20;4:3757. doi: 10.1038/srep03757.

2.

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.

Stornaiuolo M, Bruno A, Botta L, La Regina G, Cosconati S, Silvestri R, Marinelli L, Novellino E.

Sci Rep. 2015 Oct 20;5:15453. doi: 10.1038/srep15453.

3.
4.

Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.

Cawston EE, Redmond WJ, Breen CM, Grimsey NL, Connor M, Glass M.

Br J Pharmacol. 2013 Oct;170(4):893-907. doi: 10.1111/bph.12329.

5.

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.

Fay JF, Farrens DL.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8469-74. doi: 10.1073/pnas.1500895112.

6.

Parameterization of Org27569: an allosteric modulator of the cannabinoid CB1 G protein-coupled receptor.

Iliff HA, Lynch DL, Kotsikorou E, Reggio PH.

J Comput Chem. 2011 Jul 30;32(10):2119-26. doi: 10.1002/jcc.21794.

7.

The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.

Fay JF, Farrens DL.

Biochemistry. 2013 Nov 19;52(46):8286-94. doi: 10.1021/bi400842k.

8.

Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1).

Mahmoud MM, Ali HI, Ahn KH, Damaraju A, Samala S, Pulipati VK, Kolluru S, Kendall DA, Lu D.

J Med Chem. 2013 Oct 24;56(20):7965-75. doi: 10.1021/jm4009828.

9.
10.

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.

Shore DM, Baillie GL, Hurst DH, Navas F 3rd, Seltzman HH, Marcu JP, Abood ME, Ross RA, Reggio PH.

J Biol Chem. 2014 Feb 28;289(9):5828-45. doi: 10.1074/jbc.M113.478495.

11.

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.

Khajehali E, Malone DT, Glass M, Sexton PM, Christopoulos A, Leach K.

Mol Pharmacol. 2015 Aug;88(2):368-79. doi: 10.1124/mol.115.099192.

12.

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.

Gamage TF, Ignatowska-Jankowska BM, Wiley JL, Abdelrahman M, Trembleau L, Greig IR, Thakur GA, Tichkule R, Poklis J, Ross RA, Pertwee RG, Lichtman AH.

Behav Pharmacol. 2014 Apr;25(2):182-5. doi: 10.1097/FBP.0000000000000027.

13.

Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).

Ahn KH, Mahmoud MM, Shim JY, Kendall DA.

J Biol Chem. 2013 Apr 5;288(14):9790-800. doi: 10.1074/jbc.M112.438804.

14.

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.

Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P.

Br J Pharmacol. 2007 Nov;152(5):805-14.

15.

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).

Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA.

J Med Chem. 2016 Jan 14;59(1):44-60. doi: 10.1021/acs.jmedchem.5b01303.

16.

Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.

Bauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch J.

J Biol Chem. 2012 Oct 26;287(44):36944-67. doi: 10.1074/jbc.M112.382481.

17.

Allosteric modulation of the cannabinoid CB1 receptor.

Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, Pertwee RG, Ross RA.

Mol Pharmacol. 2005 Nov;68(5):1484-95.

18.

Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor.

Qiao CJ, Ali HI, Ahn KH, Kolluru S, Kendall DA, Lu D.

Eur J Med Chem. 2016 Oct 4;121:517-29. doi: 10.1016/j.ejmech.2016.05.044.

PMID:
27318976
19.

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

Baillie GL, Horswill JG, Anavi-Goffer S, Reggio PH, Bolognini D, Abood ME, McAllister S, Strange PG, Stephens GJ, Pertwee RG, Ross RA.

Mol Pharmacol. 2013 Feb;83(2):322-38. doi: 10.1124/mol.112.080879.

20.

Investigation of receptor binding and functional characteristics of hemopressin(1-7).

Dvorácskó S, Tömböly C, Berkecz R, Keresztes A.

Neuropeptides. 2016 Aug;58:15-22. doi: 10.1016/j.npep.2016.02.001.

PMID:
26895730

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