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An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.

Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1491-6. doi: 10.1073/pnas.1323535111. Epub 2014 Jan 16.


Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.

Žumer K, Plemenitaš A, Saksela K, Peterlin BM.

Nucleic Acids Res. 2011 Oct;39(18):7908-19. doi: 10.1093/nar/gkr527. Epub 2011 Jun 30.


The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes.

Barrandon C, Bonnet F, Nguyen VT, Labas V, Bensaude O.

Mol Cell Biol. 2007 Oct;27(20):6996-7006. Epub 2007 Aug 20.


Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57. doi: 10.1073/pnas.1512081112. Epub 2015 Jul 27.


AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.

Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM.

Mol Cell Biol. 2007 Dec;27(24):8815-23. Epub 2007 Oct 15.


Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10.


Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.

Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):535-40. doi: 10.1073/pnas.1119351109. Epub 2011 Dec 27.


The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.

Krueger BJ, Varzavand K, Cooper JJ, Price DH.

PLoS One. 2010 Aug 23;5(8):e12335. doi: 10.1371/journal.pone.0012335.


Aire's partners in the molecular control of immunological tolerance.

Abramson J, Giraud M, Benoist C, Mathis D.

Cell. 2010 Jan 8;140(1):123-35. doi: 10.1016/j.cell.2009.12.030.


Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855. Epub 2011 Nov 14.


Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

Koh AS, Kingston RE, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13016-21. doi: 10.1073/pnas.1004436107. Epub 2010 Jul 6.


Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.

Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.

J Immunol. 2015 Nov 15;195(10):4641-9. doi: 10.4049/jimmunol.1501026. Epub 2015 Oct 9.


LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.

Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.

Nucleic Acids Res. 2008 Apr;36(7):2219-29. doi: 10.1093/nar/gkn061. Epub 2008 Feb 16.


The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.

Venanzi ES, Melamed R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5. doi: 10.1073/pnas.0808070105. Epub 2008 Oct 6.


7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.

Eilebrecht S, Benecke BJ, Benecke A.

RNA Biol. 2011 Nov-Dec;8(6):1084-93. doi: 10.4161/rna.8.6.17015. Epub 2011 Nov 1.


Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.

Mol Cell. 2003 Oct;12(4):971-82.


Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.

Van Herreweghe E, Egloff S, Goiffon I, Jády BE, Froment C, Monsarrat B, Kiss T.

EMBO J. 2007 Aug 8;26(15):3570-80. Epub 2007 Jul 5.


Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.

Cho WK, Jang MK, Huang K, Pise-Masison CA, Brady JN.

J Virol. 2010 Dec;84(24):12801-9. doi: 10.1128/JVI.00943-10. Epub 2010 Oct 6.


FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

Shao W, Zumer K, Fujinaga K, Peterlin BM.

J Biol Chem. 2016 Aug 19;291(34):17953-63. doi: 10.1074/jbc.M116.724401. Epub 2016 Jun 30.


Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.

Yang S, Bansal K, Lopes J, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1833-8. doi: 10.1073/pnas.1222023110. Epub 2013 Jan 14.

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