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Items: 1 to 20 of 104

1.

The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel.

Chen P, Zhu S, Wang Y, Mu Q, Wu Y, Xia Q, Zhang X, Sun H, Tao J, Hu H, Lu P, Ouyang H.

Biomaterials. 2014 Mar;35(9):2827-36. doi: 10.1016/j.biomaterials.2013.12.076. Epub 2014 Jan 11.

PMID:
24424207
2.

Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis.

Chu X, You H, Yuan X, Zhao W, Li W, Guo X.

Int J Mol Med. 2013 May;31(5):1222-8. doi: 10.3892/ijmm.2013.1318. Epub 2013 Mar 26.

PMID:
23546441
3.

The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.

He Y, Zheng Q, Jiang M, Sun S, Christiansen TG, Kassem M, Karsdal MA, Bay-Jensen AC.

PLoS One. 2015 Apr 24;10(4):e0122700. doi: 10.1371/journal.pone.0122700. eCollection 2015.

4.

[Protective effect of LR-90 on articular cartilage in rabbit model of osteoarthritis].

Huang K, Zhang J, Wan J, Lu J, Gao Y.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Mar;45(2):187-94. Chinese.

PMID:
27273993
5.

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.

Larkin J, Lohr TA, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Genell C, Miller RE, Tran PB, Malfait AM, Maier CC, Matheny CJ.

Osteoarthritis Cartilage. 2015 Aug;23(8):1254-66. doi: 10.1016/j.joca.2015.02.778. Epub 2015 Mar 20.

6.

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW.

Arthritis Rheum. 2007 Feb;56(2):575-85.

7.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA.

J Med Chem. 2012 Aug 23;55(16):7061-79. doi: 10.1021/jm300449x. Epub 2012 Aug 14.

PMID:
22891645
8.

Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation.

Malfait AM, Tortorella M, Thompson J, Hills R, Meyer DM, Jaffee BD, Chinn K, Ghoreishi-Haack N, Markosyan S, Arner EC.

Osteoarthritis Cartilage. 2009 May;17(5):627-35. doi: 10.1016/j.joca.2008.10.005. Epub 2008 Nov 1.

9.

ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.

Verma P, Dalal K.

J Cell Biochem. 2011 Dec;112(12):3507-14. doi: 10.1002/jcb.23298. Review.

PMID:
21815191
10.

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T.

Arthritis Rheum. 2009 Jul;60(7):2019-27. doi: 10.1002/art.24654.

11.

Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.

Huh JE, Baek YH, Ryu SR, Lee JD, Choi DY, Park DS.

Int Immunopharmacol. 2009 Feb;9(2):230-40. doi: 10.1016/j.intimp.2008.11.016. Epub 2008 Dec 17.

PMID:
19100343
12.

Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.

Pratta MA, Su JL, Leesnitzer MA, Struglics A, Larsson S, Lohmander LS, Kumar S.

Osteoarthritis Cartilage. 2006 Jul;14(7):702-13. Epub 2006 Mar 20.

13.

Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).

Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M.

J Bone Miner Res. 2004 Aug;19(8):1308-19. Epub 2004 Mar 29.

14.

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Yamamoto K, Troeberg L, Scilabra SD, Pelosi M, Murphy CL, Strickland DK, Nagase H.

FASEB J. 2013 Feb;27(2):511-21. doi: 10.1096/fj.12-216671. Epub 2012 Oct 11.

15.

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.

Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, Flannery CR, Kanki K, Wang E, Peluso D, Yang Z, Majumdar MK, Morris EA.

Arthritis Rheum. 2004 Aug;50(8):2547-58.

16.

Effects of a bisphosphonate on bone histomorphometry and dynamics in the canine cruciate deficiency model of osteoarthritis.

Myers SL, Brandt KD, Burr DB, O'Connor BL, Albrecht M.

J Rheumatol. 1999 Dec;26(12):2645-53.

PMID:
10606377
17.

Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis.

Sabatini M, Lesur C, Thomas M, Chomel A, Anract P, de Nanteuil G, Pastoureau P.

Arthritis Rheum. 2005 Jan;52(1):171-80.

18.

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.

Majumdar MK, Askew R, Schelling S, Stedman N, Blanchet T, Hopkins B, Morris EA, Glasson SS.

Arthritis Rheum. 2007 Nov;56(11):3670-4.

19.

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine.

Swearingen CA, Carpenter JW, Siegel R, Brittain IJ, Dotzlaf J, Durham TB, Toth JL, Laska DA, Marimuthu J, Liu C, Brown DP, Carter QL, Wiley MR, Duffin KL, Mitchell PG, Thirunavukkarasu K.

Osteoarthritis Cartilage. 2010 Sep;18(9):1150-8. doi: 10.1016/j.joca.2010.06.011. Epub 2010 Jul 13.

20.

VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts.

Pérez-García S, Carrión M, Gutiérrez-Cañas I, González-Álvaro I, Gomariz RP, Juarranz Y.

J Cell Mol Med. 2016 Apr;20(4):678-87. doi: 10.1111/jcmm.12777. Epub 2016 Jan 28.

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