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Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.

Kerl K, Moreno N, Holsten T, Ahlfeld J, Mertins J, Hotfilder M, Kool M, Bartelheim K, Schleicher S, Handgretinger R, Schüller U, Meisterernst M, Frühwald MC.

Int J Cancer. 2014 Aug 15;135(4):989-95. doi: 10.1002/ijc.28719. Epub 2014 Jan 25.


Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.

Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A.

J Clin Invest. 2011 Jan;121(1):148-60. doi: 10.1172/JCI42874. Epub 2010 Dec 22.


Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.


Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation.

Nakamura S, Nagano S, Nagao H, Ishidou Y, Yokouchi M, Abematsu M, Yamamoto T, Komiya S, Setoguchi T.

PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.


Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.

Li SH, Fu J, Watkins DN, Srivastava RK, Shankar S.

Mol Cell Biochem. 2013 Jan;373(1-2):217-27. doi: 10.1007/s11010-012-1493-6. Epub 2012 Nov 6.


Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres.

Ding D, Lim KS, Eberhart CG.

Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.


Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs.

Meister MT, Boedicker C, Graab U, Hugle M, Hahn H, Klingebiel T, Fulda S.

Cancer Lett. 2016 Oct 28;381(2):287-95. doi: 10.1016/j.canlet.2016.07.007. Epub 2016 Aug 10.


Arsenic trioxide inhibits the Hedgehog pathway which is aberrantly activated in acute promyelocytic leukemia.

Yang D, Cao F, Ye X, Zhao H, Liu X, Li Y, Shi C, Wang H, Zhou J.

Acta Haematol. 2013;130(4):260-7. doi: 10.1159/000351603. Epub 2013 Jul 17.


Arsenic: a potentially useful poison for Hedgehog-driven cancers.

Raju GP.

J Clin Invest. 2011 Jan;121(1):14-6. doi: 10.1172/JCI45692. Epub 2010 Dec 22.


Arsenic trioxide induces differentiation of CD133+ hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model.

Zhang KZ, Zhang QB, Zhang QB, Sun HC, Ao JY, Chai ZT, Zhu XD, Lu L, Zhang YY, Bu Y, Kong LQ, Tang ZY.

J Hematol Oncol. 2014 Mar 30;7:28. doi: 10.1186/1756-8722-7-28.


In the war against solid tumors arsenic trioxide needs partners.

Subbarayan PR, Ardalan B.

J Gastrointest Cancer. 2014 Sep;45(3):363-71. doi: 10.1007/s12029-014-9617-8. Review.


The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW, Wang HY.

Clin Cancer Res. 2013 Apr 15;19(8):2014-24. doi: 10.1158/1078-0432.CCR-12-0349. Epub 2013 Mar 14.


β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.

Mol Cancer. 2015 Feb 3;14:17. doi: 10.1186/s12943-015-0294-4.


TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis.

Liu ZM, Tseng HY, Cheng YL, Yeh BW, Wu WJ, Huang HS.

Toxicol Appl Pharmacol. 2015 May 15;285(1):41-50. doi: 10.1016/j.taap.2015.03.007. Epub 2015 Mar 16.


Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo.

Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, Lei XH, Sun X, Liu X, Wang HB, Li XF, Yang DB, Sun Y, Zhao ZF, Jiang T, Li YL, Jiang CL.

CNS Neurosci Ther. 2013 Dec;19(12):926-36. doi: 10.1111/cns.12163. Epub 2013 Oct 25.


Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L.

Mol Cancer. 2014 May 31;13:133. doi: 10.1186/1476-4598-13-133.


Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-κB signaling in cervical cancer.

Chang YW, Chen MW, Chiu CF, Hong CC, Cheng CC, Hsiao M, Chen CA, Wei LH, Su JL.

Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.


Rhabdoid tumor growth is inhibited by flavopiridol.

Smith ME, Cimica V, Chinni S, Challagulla K, Mani S, Kalpana GV.

Clin Cancer Res. 2008 Jan 15;14(2):523-32. doi: 10.1158/1078-0432.CCR-07-1347.


The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

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