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Genetic predictors of antidepressant side effects: a grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study.

Hodgson K, Uher R, Crawford AA, Lewis G, O'Donovan MC, Keers R, Dernovsek MZ, Mors O, Hauser J, Souery D, Maier W, Henigsberg N, Rietschel M, Placentino A, Aitchison K, Farmer A, Davis O, McGuffin P.

J Psychopharmacol. 2014 Feb;28(2):142-50. doi: 10.1177/0269881113517957. Epub 2014 Jan 10.


Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project.

Perroud N, Aitchison KJ, Uher R, Smith R, Huezo-Diaz P, Marusic A, Maier W, Mors O, Placentino A, Henigsberg N, Rietschel M, Hauser J, Souery D, Kapelski P, Bonvicini C, Zobel A, Jorgensen L, Petrovic A, Kalember P, Schulze TG, Gupta B, Gray J, Lewis CM, Farmer AE, McGuffin P, Craig I.

Neuropsychopharmacology. 2009 Nov;34(12):2517-28. doi: 10.1038/npp.2009.81. Epub 2009 Jul 29.


Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.

Perroud N, Uher R, Ng MY, Guipponi M, Hauser J, Henigsberg N, Maier W, Mors O, Gennarelli M, Rietschel M, Souery D, Dernovsek MZ, Stamp AS, Lathrop M, Farmer A, Breen G, Aitchison KJ, Lewis CM, Craig IW, McGuffin P.

Pharmacogenomics J. 2012 Feb;12(1):68-77. doi: 10.1038/tpj.2010.70. Epub 2010 Sep 28.


Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.

Uher R, Perroud N, Ng MY, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P, Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM, McGuffin P.

Am J Psychiatry. 2010 May;167(5):555-64. doi: 10.1176/appi.ajp.2009.09070932. Epub 2010 Apr 1.


Exploring the role of drug-metabolising enzymes in antidepressant side effects.

Hodgson K, Tansey KE, Uher R, Dernovšek MZ, Mors O, Hauser J, Souery D, Maier W, Henigsberg N, Rietschel M, Placentino A, Craig IW, Aitchison KJ, Farmer AE, Dobson RJ, McGuffin P.

Psychopharmacology (Berl). 2015 Jul;232(14):2609-17. doi: 10.1007/s00213-015-3898-x. Epub 2015 Mar 12.


Genetic predictors of response to antidepressants in the GENDEP project.

Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, Hauser J, Maier W, Kozel D, Henigsberg N, Barreto M, Placentino A, Dernovsek MZ, Schulze TG, Kalember P, Zobel A, Czerski PM, Larsen ER, Souery D, Giovannini C, Gray JM, Lewis CM, Farmer A, Aitchison KJ, McGuffin P, Craig I.

Pharmacogenomics J. 2009 Aug;9(4):225-33. doi: 10.1038/tpj.2009.12. Epub 2009 Apr 14.


A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C).

Brasch-Andersen C, Møller MU, Christiansen L, Thinggaard M, Otto M, Brøsen K, Sindrup SH.

Eur J Clin Pharmacol. 2011 Nov;67(11):1131-7. doi: 10.1007/s00228-011-1056-x. Epub 2011 May 26.


Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.

Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC.

Biol Psychiatry. 2011 Feb 15;69(4):360-5. doi: 10.1016/j.biopsych.2010.08.011. Epub 2010 Oct 20.


Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR.

Strohmaier J, Wüst S, Uher R, Henigsberg N, Mors O, Hauser J, Souery D, Zobel A, Dernovsek MZ, Streit F, Schmäl C, Kozel D, Placentino A, Farmer A, McGuffin P, Aitchison KJ, Rietschel M.

World J Biol Psychiatry. 2011 Oct;12(7):528-38. doi: 10.3109/15622975.2011.559270. Epub 2011 Mar 9.


DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP.

Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE.

Transl Psychiatry. 2013 Sep 3;3:e300. doi: 10.1038/tp.2013.73.


Citalopram versus other anti-depressive agents for depression.

Cipriani A, Purgato M, Furukawa TA, Trespidi C, Imperadore G, Signoretti A, Churchill R, Watanabe N, Barbui C.

Cochrane Database Syst Rev. 2012 Jul 11;(7):CD006534. doi: 10.1002/14651858.CD006534.pub2. Review.


Variation in GNB3 predicts response and adverse reactions to antidepressants.

Keers R, Bonvicini C, Scassellati C, Uher R, Placentino A, Giovannini C, Rietschel M, Henigsberg N, Kozel D, Mors O, Maier W, Hauser J, Souery D, Mendlewicz J, Schmäl C, Zobel A, Larsen ER, Szczepankiewicz A, Kovacic Z, Elkin A, Craig I, McGuffin P, Farmer AE, Aitchison KJ, Gennarelli M.

J Psychopharmacol. 2011 Jul;25(7):867-74. doi: 10.1177/0269881110376683. Epub 2010 Sep 8.


Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1.

Secher A, Bukh J, Bock C, Koefoed P, Rasmussen HB, Werge T, Kessing LV, Mellerup E.

Int Clin Psychopharmacol. 2009 Jul;24(4):199-203. doi: 10.1097/YIC.0b013e32832d6be2.


Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.

Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, Uhr M, Dose T, Unschuld PG, Zihl J, Binder E, Müller-Myhsok B, Holsboer F, Lucae S.

Eur Neuropsychopharmacol. 2013 Jul;23(7):653-62. doi: 10.1016/j.euroneuro.2012.08.010. Epub 2012 Sep 29.


Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project.

Keers R, Uher R, Huezo-Diaz P, Smith R, Jaffee S, Rietschel M, Henigsberg N, Kozel D, Mors O, Maier W, Zobel A, Hauser J, Souery D, Placentino A, Larsen ER, Dmitrzak-Weglarz M, Gupta B, Hoda F, Craig I, McGuffin P, Farmer AE, Aitchison KJ.

Pharmacogenomics J. 2011 Apr;11(2):138-45. doi: 10.1038/tpj.2010.14. Epub 2010 Mar 9.


Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.

GENDEP Investigators; MARS Investigators; STAR*D Investigators.

Am J Psychiatry. 2013 Feb;170(2):207-17. doi: 10.1176/appi.ajp.2012.12020237.


Altered RNA editing of serotonin 2C receptor in a rat model of depression.

Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T.

Neurosci Res. 2005 Sep;53(1):69-76.


Moderation of antidepressant response by the serotonin transporter gene.

Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, Mors O, Maier W, Hauser J, Souery D, Placentino A, Zobel A, Larsen ER, Czerski PM, Gupta B, Hoda F, Perroud N, Farmer A, Craig I, Aitchison KJ, McGuffin P.

Br J Psychiatry. 2009 Jul;195(1):30-8. doi: 10.1192/bjp.bp.108.062521.


[Association between polymorphisms of ins/del in the 5-HTT gene and T102C in the 5HTR2A gene and the drug response for escitalopram and nortriptyline in depressed patients].

Rajewska-Rager A, Dmitrzak-Weglarz M, Kapelski P, Skibińska M, Kaczmarkiewicz-Fass M, Hauser J.

Psychiatr Pol. 2008 Nov-Dec;42(6):903-14. Polish.


Antidepressants for people with epilepsy and depression.

Maguire MJ, Weston J, Singh J, Marson AG.

Cochrane Database Syst Rev. 2014 Dec 3;(12):CD010682. doi: 10.1002/14651858.CD010682.pub2. Review.


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