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Items: 1 to 20 of 101


Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters.

Hraha TH, Bernard AB, Nguyen LM, Anseth KS, Benninger RK.

Biophys J. 2014 Jan 7;106(1):299-309. doi: 10.1016/j.bpj.2013.11.026.


Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

Rose T, Efendic S, Rupnik M.

J Gen Physiol. 2007 Jun;129(6):493-508.


Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet.

Benninger RK, Head WS, Zhang M, Satin LS, Piston DW.

J Physiol. 2011 Nov 15;589(Pt 22):5453-66. doi: 10.1113/jphysiol.2011.218909. Epub 2011 Sep 19.


The relationship between membrane potential and calcium dynamics in glucose-stimulated beta cell syncytium in acute mouse pancreas tissue slices.

Dolenšek J, Stožer A, Skelin Klemen M, Miller EW, Slak Rupnik M.

PLoS One. 2013 Dec 6;8(12):e82374. doi: 10.1371/journal.pone.0082374. eCollection 2013.


Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

Fridlyand LE, Harbeck MC, Roe MW, Philipson LH.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1924-33. Epub 2007 Oct 10.


Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets.

Quesada I, Villalobos C, Núñez L, Chamero P, Alonso MT, Nadal A, García-Sancho J.

Cell Calcium. 2008 Jan;43(1):39-47. Epub 2007 May 11.


Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics.

Benninger RK, Hutchens T, Head WS, McCaughey MJ, Zhang M, Le Marchand SJ, Satin LS, Piston DW.

Biophys J. 2014 Dec 2;107(11):2723-33. doi: 10.1016/j.bpj.2014.10.048. Epub 2014 Dec 2.


Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution.

Schulze T, Morsi M, Brüning D, Schumacher K, Rustenbeck I.

Endocrine. 2016 Mar;51(3):440-7. doi: 10.1007/s12020-015-0701-z. Epub 2015 Jul 31.


Synchronization of Ca(2+)-signals within insulin-secreting pseudoislets: effects of gap-junctional uncouplers.

Squires PE, Hauge-Evans AC, Persaud SJ, Jones PM.

Cell Calcium. 2000 May;27(5):287-96.


Gap junction coupling and calcium waves in the pancreatic islet.

Benninger RK, Zhang M, Head WS, Satin LS, Piston DW.

Biophys J. 2008 Dec;95(11):5048-61. doi: 10.1529/biophysj.108.140863. Epub 2008 Sep 19.


Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability.

Hraha TH, Westacott MJ, Pozzoli M, Notary AM, McClatchey PM, Benninger RK.

PLoS Comput Biol. 2014 Sep 4;10(9):e1003819. doi: 10.1371/journal.pcbi.1003819. eCollection 2014 Sep.


Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets.

Zhang M, Fendler B, Peercy B, Goel P, Bertram R, Sherman A, Satin L.

Biophys J. 2008 Nov 15;95(10):4676-88. doi: 10.1529/biophysj.107.125088. Epub 2008 Aug 15.


Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA.

J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13.


Effect of 17beta-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans.

Al-Majed HT, Squires PE, Persaud SJ, Huang GC, Amiel S, Whitehouse BJ, Jones PM.

Pancreas. 2005 May;30(4):307-13.


Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis.

Chen YD, Wang S, Sherman A.

Biophys J. 2008 Sep;95(5):2226-41. doi: 10.1529/biophysj.107.124990. Epub 2008 May 30.


Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus.

Benninger RK, Remedi MS, Head WS, Ustione A, Piston DW, Nichols CG.

Diabetologia. 2011 May;54(5):1087-97. doi: 10.1007/s00125-010-2039-7. Epub 2011 Jan 27.


Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE.

Diabetes. 2010 Jul;59(7):1686-93. doi: 10.2337/db09-0630. Epub 2010 Apr 22.


Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.


Intra- and inter-islet synchronization of metabolically driven insulin secretion.

Pedersen MG, Bertram R, Sherman A.

Biophys J. 2005 Jul;89(1):107-19. Epub 2005 Apr 15.

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