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Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors.

Sedlakova O, Svastova E, Takacova M, Kopacek J, Pastorek J, Pastorekova S.

Front Physiol. 2014 Jan 8;4:400. doi: 10.3389/fphys.2013.00400. Review.


Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use.

Pastorek J, Pastorekova S.

Semin Cancer Biol. 2015 Apr;31:52-64. doi: 10.1016/j.semcancer.2014.08.002. Review.


Carbonic anhydrase IX: a hypoxia-controlled "catalyst" of cell migration.

Svastova E, Pastorekova S.

Cell Adh Migr. 2013 Mar-Apr;7(2):226-31. doi: 10.4161/cam.23257.


Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia.

Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, Kopacek J, Pastorekova S.

Int J Oncol. 2006 Oct;29(4):1025-33.


Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

Ditte P, Dequiedt F, Svastova E, Hulikova A, Ohradanova-Repic A, Zatovicova M, Csaderova L, Kopacek J, Supuran CT, Pastorekova S, Pastorek J.

Cancer Res. 2011 Dec 15;71(24):7558-67. doi: 10.1158/0008-5472.CAN-11-2520.


Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, Pouysségur J.

Cancer Res. 2009 Jan 1;69(1):358-68. doi: 10.1158/0008-5472.CAN-08-2470.


Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain.

Zatovicova M, Jelenska L, Hulikova A, Csaderova L, Ditte Z, Ditte P, Goliasova T, Pastorek J, Pastorekova S.

Curr Pharm Des. 2010;16(29):3255-63. Review.


The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration.

Csaderova L, Debreova M, Radvak P, Stano M, Vrestiakova M, Kopacek J, Pastorekova S, Svastova E.

Front Physiol. 2013 Oct 1;4:271. doi: 10.3389/fphys.2013.00271.


Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

Svastova E, Witarski W, Csaderova L, Kosik I, Skvarkova L, Hulikova A, Zatovicova M, Barathova M, Kopacek J, Pastorek J, Pastorekova S.

J Biol Chem. 2012 Jan 27;287(5):3392-402. doi: 10.1074/jbc.M111.286062.


125I-Labeled mouse anti-human carbonic anhydrase IX monoclonal antibody.

Shan L.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2012 May 3 [updated 2012 May 30].


Histopathological determinants of tumor resistance: a special look to the immunohistochemical expression of carbonic anhydrase IX in human cancers.

Ilardi G, Zambrano N, Merolla F, Siano M, Varricchio S, Vecchione M, De Rosa G, Mascolo M, Staibano S.

Curr Med Chem. 2014;21(14):1569-82. Review.


Carbonic anhydrase IX: regulation and role in cancer.

Benej M, Pastorekova S, Pastorek J.

Subcell Biochem. 2014;75:199-219. doi: 10.1007/978-94-007-7359-2_11. Review.


The effects of CA IX catalysis products within tumor microenvironment.

Santi A, Caselli A, Paoli P, Corti D, Camici G, Pieraccini G, Taddei ML, Serni S, Chiarugi P, Cirri P.

Cell Commun Signal. 2013 Oct 29;11:81. doi: 10.1186/1478-811X-11-81.


Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio.

Esbaugh AJ, Perry SF, Gilmour KM.

Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R150-60. doi: 10.1152/ajpregu.90685.2008.


Inhibition of carbonic anhydrase IX as a novel anticancer mechanism.

Supuran CT.

World J Clin Oncol. 2012 Jul 10;3(7):98-103. doi: 10.5306/wjco.v3.i7.98.


Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.

Tripodi SA, Del Vecchio MT, Supuran CT, Scozzafava A, Gabrielli MG, Pastorekova S, Rossie R, Fasolis G, Puccetti L.

J Enzyme Inhib Med Chem. 2004 Jun;19(3):287-91.


Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

Ivanov S, Liao SY, Ivanova A, Danilkovitch-Miagkova A, Tarasova N, Weirich G, Merrill MJ, Proescholdt MA, Oldfield EH, Lee J, Zavada J, Waheed A, Sly W, Lerman MI, Stanbridge EJ.

Am J Pathol. 2001 Mar;158(3):905-19.


Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.

Vidlickova I, Dequiedt F, Jelenska L, Sedlakova O, Pastorek M, Stuchlik S, Pastorek J, Zatovicova M, Pastorekova S.

BMC Cancer. 2016 Mar 19;16:239. doi: 10.1186/s12885-016-2267-4.


Expression of hypoxia-inducible carbonic anhydrases in brain tumors.

Proescholdt MA, Mayer C, Kubitza M, Schubert T, Liao SY, Stanbridge EJ, Ivanov S, Oldfield EH, Brawanski A, Merrill MJ.

Neuro Oncol. 2005 Oct;7(4):465-75.


Tumor-associated carbonic anhydrases and their clinical significance.

Pastorekova S, Parkkila S, Zavada J.

Adv Clin Chem. 2006;42:167-216. Review.

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