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D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family.

Merk M, Mitchell RA, Endres S, Bucala R.

Cytokine. 2012 Jul;59(1):10-7. doi: 10.1016/j.cyto.2012.03.014. Review.


The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, Bucala R.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E577-85. doi: 10.1073/pnas.1102941108.


D-dopachrome tautomerase in adipose tissue inflammation and wound repair.

Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R.

J Cell Mol Med. 2017 Jan;21(1):35-45. doi: 10.1111/jcmm.12936.


Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function.

Dickerhof N, Schindler L, Bernhagen J, Kettle AJ, Hampton MB.

Free Radic Biol Med. 2015 Dec;89:498-511. doi: 10.1016/j.freeradbiomed.2015.09.009.


Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.

Rajasekaran D, Zierow S, Syed M, Bucala R, Bhandari V, Lolis EJ.

FASEB J. 2014 Nov;28(11):4961-71. doi: 10.1096/fj.14-256636.


MIF family members cooperatively inhibit p53 expression and activity.

Brock SE, Rendon BE, Xin D, Yaddanapudi K, Mitchell RA.

PLoS One. 2014 Jun 16;9(6):e99795. doi: 10.1371/journal.pone.0099795.


The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through β-catenin-dependent and -independent mechanisms.

Xin D, Rendon BE, Zhao M, Winner M, McGhee Coleman A, Mitchell RA.

Mol Cancer Res. 2010 Dec;8(12):1601-9. doi: 10.1158/1541-7786.MCR-10-0101.


CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer.

Zheng YX, Yang M, Rong TT, Yuan XL, Ma YH, Wang ZH, Shen LS, Cui L.

World J Gastroenterol. 2012 May 14;18(18):2253-61. doi: 10.3748/wjg.v18.i18.2253.


Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.

Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J.

Biochemistry. 1999 Mar 16;38(11):3268-79.


Non-viral nanoparticle delivers small interfering RNA to macrophages in vitro and in vivo.

Zhang M, Gao Y, Caja K, Zhao B, Kim JA.

PLoS One. 2015 Mar 23;10(3):e0118472. doi: 10.1371/journal.pone.0118472.


Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.

Mawhinney L, Armstrong ME, O' Reilly C, Bucala R, Leng L, Fingerle-Rowson G, Fayne D, Keane MP, Tynan A, Maher L, Cooke G, Lloyd D, Conroy H, Donnelly SC.

Mol Med. 2015 Apr 16;20:729-35. doi: 10.2119/molmed.2014.00136.


Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells.

Baron N, Deuster O, Noelker C, Stüer C, Strik H, Schaller C, Dodel R, Meyer B, Bacher M.

J Neurosci Res. 2011 May;89(5):711-7. doi: 10.1002/jnr.22595.


Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment.

Zhang M, Yan L, Kim JA.

Cancer Gene Ther. 2015 Oct;22(10):463-74. doi: 10.1038/cgt.2015.42.


Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma.

Oliveira CS, de Bock CE, Molloy TJ, Sadeqzadeh E, Geng XY, Hersey P, Zhang XD, Thorne RF.

BMC Cancer. 2014 Aug 29;14:630. doi: 10.1186/1471-2407-14-630.


Macrophage migration inhibitory factor produced by the tumour stroma but not by tumour cells regulates angiogenesis in the B16-F10 melanoma model.

Girard E, Strathdee C, Trueblood E, Quéva C.

Br J Cancer. 2012 Oct 23;107(9):1498-505. doi: 10.1038/bjc.2012.392.


Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells.

Ohta S, Misawa A, Fukaya R, Inoue S, Kanemura Y, Okano H, Kawakami Y, Toda M.

J Cell Sci. 2012 Jul 1;125(Pt 13):3210-20. doi: 10.1242/jcs.102210.


D-dopachrome tautomerase is over-expressed in pancreatic ductal adenocarcinoma and acts cooperatively with macrophage migration inhibitory factor to promote cancer growth.

Guo D, Guo J, Yao J, Jiang K, Hu J, Wang B, Liu H, Lin L, Sun W, Jiang X.

Int J Cancer. 2016 Nov 1;139(9):2056-67. doi: 10.1002/ijc.30278.

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