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Items: 1 to 20 of 94

1.

In search of potent 5-HT6 receptor inverse agonists.

Hostetler G, Dunn D, McKenna BA, Kopec K, Chatterjee S.

Chem Biol Drug Des. 2014 Jun;83(6):666-9. doi: 10.1111/cbdd.12279.

PMID:
24406060
2.

1-Thia-4,7-diaza-spiro[4.4]nonane-3,6-dione: a structural motif for 5-hydroxytryptamine 6 receptor antagonism.

Hostetler G, Dunn D, McKenna BA, Kopec K, Chatterjee S.

Chem Biol Drug Des. 2014 Feb;83(2):149-53. doi: 10.1111/cbdd.12240.

PMID:
24119217
3.

Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists.

Hostetler G, Dunn D, McKenna BA, Kopec K, Chatterjee S.

Bioorg Med Chem Lett. 2014 May 1;24(9):2094-7. doi: 10.1016/j.bmcl.2014.03.049.

PMID:
24704027
4.

From an atypical wake-promoting agent to potent histamine-3 receptor inverse agonists.

Dunn D, Raddatz R, Ator MA, Bacon ER, Chatterjee S.

Chem Biol Drug Des. 2013 Mar;81(3):433-5. doi: 10.1111/cbdd.12094.

PMID:
23205610
5.

Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

Sikazwe D, Bondarev ML, Dukat M, Rangisetty JB, Roth BL, Glennon RA.

J Med Chem. 2006 Aug 24;49(17):5217-25.

PMID:
16913710
6.

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Grunewald GL, Seim MR, Regier RC, Martin JL, Gee CL, Drinkwater N, Criscione KR.

J Med Chem. 2006 Sep 7;49(18):5424-33.

PMID:
16942016
7.

The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.

Bailey JM, Scott JS, Basilla JB, Bolton VJ, Boyfield I, Evans DG, Fleury E, Heightman TD, Jarvie EM, Lawless K, Matthews KL, McKay F, Mok H, Muir A, Orlek BS, Sanger GJ, Stemp G, Stevens AJ, Thompson M, Ward J, Vaidya K, Westaway SM.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6452-8. doi: 10.1016/j.bmcl.2009.09.027.

PMID:
19804969
8.

(+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists.

Shah JH, Kline RH, Geter-Douglass B, Izenwasser S, Witkin JM, Newman AH.

J Med Chem. 1996 Aug 16;39(17):3423-8.

PMID:
8765528
9.

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.

Fauber BP, René O, Deng Y, DeVoss J, Eidenschenk C, Everett C, Ganguli A, Gobbi A, Hawkins J, Johnson AR, La H, Lesch J, Lockey P, Norman M, Ouyang W, Summerhill S, Wong H.

J Med Chem. 2015 Jul 9;58(13):5308-22. doi: 10.1021/acs.jmedchem.5b00597.

PMID:
26061388
10.

Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.

Taylor SJ, Soleymanzadeh F, Muegge I, Akiba I, Taki N, Ueda S, Mainolfi E, Eldrup AB.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2177-80. doi: 10.1016/j.bmcl.2013.01.105.

PMID:
23453841
11.

Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.

Alcalde E, Mesquida N, López-Pérez S, Frigola J, Mercè R.

J Med Chem. 2009 Feb 12;52(3):675-87. doi: 10.1021/jm8009469.

PMID:
19159187
12.

Discovery of 5-HT6 receptor ligands based on virtual HTS.

Tasler S, Kraus J, Wuzik A, Müller O, Aschenbrenner A, Cubero E, Pascual R, Quintana-Ruiz JR, Dordal A, Mercè R, Codony X.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6224-9.

PMID:
17892934
13.

Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.

Ivachtchenko A, Golovina E, Kadieva M, Mitkin O, Tkachenko S, Okun I.

Bioorg Med Chem. 2013 Aug 1;21(15):4614-27. doi: 10.1016/j.bmc.2013.05.040.

PMID:
23787290
14.

A reversed sulfonamide series of selective RORc inverse agonists.

van Niel MB, Fauber BP, Cartwright M, Gaines S, Killen JC, René O, Ward SI, de Leon Boenig G, Deng Y, Eidenschenk C, Everett C, Gancia E, Ganguli A, Gobbi A, Hawkins J, Johnson AR, Kiefer JR, La H, Lockey P, Norman M, Ouyang W, Qin A, Wakes N, Waszkowycz B, Wong H.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5769-76. doi: 10.1016/j.bmcl.2014.10.037.

PMID:
25453817
15.

Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.

Cole DC, Lennox WJ, Lombardi S, Ellingboe JW, Bernotas RC, Tawa GJ, Mazandarani H, Smith DL, Zhang G, Coupet J, Schechter LE.

J Med Chem. 2005 Jan 27;48(2):353-6.

PMID:
15658848
16.

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Mitkin OD, Tkachenko SE, Kysil VM, Okun I.

Eur J Med Chem. 2011 Apr;46(4):1189-97. doi: 10.1016/j.ejmech.2011.01.038.

PMID:
21333408
17.

5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.

Haydar SN, Yun H, Andrae PM, Mattes J, Zhang J, Kramer A, Smith DL, Huselton C, Graf R, Aschmies S, Schechter LE, Comery TA, Robichaud AJ.

J Med Chem. 2010 Mar 25;53(6):2521-7. doi: 10.1021/jm901674f.

PMID:
20170099
18.

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM.

Eur J Med Chem. 2010 Feb;45(2):782-9. doi: 10.1016/j.ejmech.2009.10.035.

PMID:
19939513
19.

Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.

Mesquida N, López-Pérez S, Dinarès I, Frigola J, Mercè R, Holenz J, Pérez R, Burgueño J, Alcalde E.

J Med Chem. 2009 Oct 8;52(19):6153-7. doi: 10.1021/jm900796p.

PMID:
19739674
20.

Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists.

Urbanek RA, Xiong H, Wu Y, Blackwell W, Steelman G, Rosamond J, Wesolowski SS, Campbell JB, Zhang M, Brockel B, Widzowski DV.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):543-7. doi: 10.1016/j.bmcl.2012.11.023.

PMID:
23237836

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