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Items: 1 to 20 of 103

1.

A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging.

Johnson PL, Goronzy JJ, Antia R.

Immunology. 2014 Jun;142(2):167-75. doi: 10.1111/imm.12244. Review.

2.

Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire.

Arnold CR, Wolf J, Brunner S, Herndler-Brandstetter D, Grubeck-Loebenstein B.

J Clin Immunol. 2011 Apr;31(2):137-46. doi: 10.1007/s10875-010-9499-x. Epub 2011 Jan 18. Review.

PMID:
21243520
3.

Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice.

Ahmed M, Lanzer KG, Yager EJ, Adams PS, Johnson LL, Blackman MA.

J Immunol. 2009 Jan 15;182(2):784-92.

4.

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.

Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA.

J Exp Med. 2008 Mar 17;205(3):711-23. doi: 10.1084/jem.20071140. Epub 2008 Mar 10.

5.

Diversity and clonal selection in the human T-cell repertoire.

Qi Q, Liu Y, Cheng Y, Glanville J, Zhang D, Lee JY, Olshen RA, Weyand CM, Boyd SD, Goronzy JJ.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13139-44. doi: 10.1073/pnas.1409155111. Epub 2014 Aug 25.

6.

Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing.

van der Weerd K, Dik WA, Schrijver B, Bogers AJ, Maat AP, van Nederveen FH, van Hagen PM, van Dongen JJ, Langerak AW, Staal FJ.

Mol Immunol. 2013 Mar;53(3):302-12. doi: 10.1016/j.molimm.2012.08.019. Epub 2012 Sep 19.

PMID:
23000520
7.

Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates.

Cicin-Sain L, Messaoudi I, Park B, Currier N, Planer S, Fischer M, Tackitt S, Nikolich-Zugich D, Legasse A, Axthelm MK, Picker LJ, Mori M, Nikolich-Zugich J.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19960-5. Epub 2007 Dec 4.

8.

The narrowing of the CD8 T cell repertoire in old age.

Blackman MA, Woodland DL.

Curr Opin Immunol. 2011 Aug;23(4):537-42. doi: 10.1016/j.coi.2011.05.005. Epub 2011 Jun 7. Review.

9.

Naive T cells: the crux of cellular immune aging?

Appay V, Sauce D.

Exp Gerontol. 2014 Jun;54:90-3. doi: 10.1016/j.exger.2014.01.003. Epub 2014 Jan 15. Review.

PMID:
24440387
10.
11.

Aging and T-cell diversity.

Goronzy JJ, Lee WW, Weyand CM.

Exp Gerontol. 2007 May;42(5):400-6. Epub 2007 Jan 10. Review.

12.

Modelling naive T-cell homeostasis: consequences of heritable cellular lifespan during ageing.

Dowling MR, Hodgkin PD.

Immunol Cell Biol. 2009 Aug-Sep;87(6):445-56. doi: 10.1038/icb.2009.11. Epub 2009 Mar 17.

PMID:
19290017
13.

Changes in the aging immune system.

Grubeck-Loebenstein B.

Biologicals. 1997 Jun;25(2):205-8. Review.

PMID:
9236053
14.

Thymectomy in early childhood: a model for premature T cell immunosenescence?

Zlamy M, Prelog M.

Rejuvenation Res. 2009 Aug;12(4):249-58. doi: 10.1089/rej.2009.0864. Review.

PMID:
19673593
15.

Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.

Okoye AA, Rohankhedkar M, Konfe AL, Abana CO, Reyes MD, Clock JA, Duell DM, Sylwester AW, Sammader P, Legasse AW, Park BS, Axthelm MK, Nikolich-┼Żugich J, Picker LJ.

J Immunol. 2015 Nov 1;195(9):4292-305. doi: 10.4049/jimmunol.1500609. Epub 2015 Sep 28.

16.

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age.

Johnson PL, Yates AJ, Goronzy JJ, Antia R.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21432-7. doi: 10.1073/pnas.1209283110. Epub 2012 Dec 10.

17.

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.

Cicin-Sain L, Smyk-Pearson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Lewinsohn DA, Nikolich-Zugich J.

J Immunol. 2010 Jun 15;184(12):6739-45. doi: 10.4049/jimmunol.0904193. Epub 2010 May 17. Erratum in: J Immunol. 2010 Oct 1;185(7):4509. Smyk-Paerson, Sue [corrected to Smyk-Pearson, Susan]; Axthelm, Michael T [corrected to Axthelm, Michael K].

18.

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis.

Goronzy JJ, Weyand CM.

Trends Immunol. 2001 May;22(5):251-5.

PMID:
11323282
19.

Ghrelin promotes thymopoiesis during aging.

Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD.

J Clin Invest. 2007 Oct;117(10):2778-90.

20.

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.

Westera L, van Hoeven V, Drylewicz J, Spierenburg G, van Velzen JF, de Boer RJ, Tesselaar K, Borghans JA.

Aging Cell. 2015 Apr;14(2):219-27. doi: 10.1111/acel.12311. Epub 2015 Jan 28.

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