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Items: 1 to 20 of 189

1.

Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro.

Wright JE, Rosowsky A, Waxman DJ, Trites D, Cucchi CA, Flatow J, Frei E 3rd.

Biochem Pharmacol. 1987 Jul 1;36(13):2209-14.

PMID:
2440437
2.

Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase.

Rosowsky A, Wright JE, Holden SA, Waxman DJ.

Biochem Pharmacol. 1990 Aug 15;40(4):851-7.

PMID:
1696821
3.

Methotrexate and gamma-tert-butyl methotrexate transport in CEM and CEM/MTX human leukemic lymphoblasts.

Wright JE, Rosowsky A, Cucchi CA, Flatow J, Frei E 3rd.

Biochem Pharmacol. 1993 Sep 1;46(5):871-6.

PMID:
8373437
5.

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G.

Biochem Pharmacol. 2002 Jan 15;63(2):105-15.

PMID:
11841783
7.

Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.

Rosowsky A, Bader H, Radike-Smith M, Cucchi CA, Wick MM, Freisheim JH.

J Med Chem. 1986 Sep;29(9):1703-9.

PMID:
3462394
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10.

Methotrexate metabolism in mutant Chinese hamster ovary cells lacking dihydrofolate reductase.

Joannon P, Whitehead VM, Rosenblatt DS, Vuchich MJ, Beaulieu D.

Biochem Pharmacol. 1987 Apr 1;36(7):1091-7.

PMID:
2436625
11.

Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver.

Fabre G, Seither R, Goldman ID.

Biochem Pharmacol. 1986 Apr 15;35(8):1325-30.

PMID:
2421732
12.

Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.

Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF.

Cancer Res. 1982 May;42(5):1655-60.

13.

Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.

Jansen G, Westerhof GR, Kathmann I, Rademaker BC, Rijksen G, Schornagel JH.

Cancer Res. 1989 May 1;49(9):2455-9. Erratum in: Cancer Res 1995 Sep 15;55(18):4203.

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17.

Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation.

McGuire JJ, Graber M, Licato N, Vincenz C, Coward JK, Nimec Z, Galivan J.

Cancer Res. 1989 Aug 15;49(16):4517-25.

18.

Enzymatic synthesis of polyglutamate derivatives of 7-hydroxymethotrexate.

McGuire JJ, Hsieh P, Bertino JR.

Biochem Pharmacol. 1984 Apr 15;33(8):1355-61.

PMID:
6201178
19.

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.

Koizumi S, Curt GA, Fine RL, Griffin JD, Chabner BA.

J Clin Invest. 1985 Mar;75(3):1008-14.

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