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CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways.

Sobolik T, Su YJ, Wells S, Ayers GD, Cook RS, Richmond A.

Mol Biol Cell. 2014 Mar;25(5):566-82. doi: 10.1091/mbc.E13-07-0360. Epub 2014 Jan 8.


miR-381 inhibited breast cancer cells proliferation, epithelial-to-mesenchymal transition and metastasis by targeting CXCR4.

Xue Y, Xu W, Zhao W, Wang W, Zhang D, Wu P.

Biomed Pharmacother. 2017 Feb;86:426-433. doi: 10.1016/j.biopha.2016.12.051. Epub 2016 Dec 21.


Inhibition of SDF-1/CXCR4-induced epithelial-mesenchymal transition by kisspeptin-10.

Gründker C, Bauerschmitz G, Knapp J, Schmidt E, Olbrich T, Emons G.

Breast Cancer Res Treat. 2015 Jul;152(1):41-50. doi: 10.1007/s10549-015-3463-7. Epub 2015 Jun 11.


Embelin Inhibits Invasion and Migration of MDA-MB-231 Breast Cancer Cells by Suppression of CXC Chemokine Receptor 4, Matrix Metalloproteinases-9/2, and Epithelial-Mesenchymal Transition.

Lee H, Ko JH, Baek SH, Nam D, Lee SG, Lee J, Yang WM, Um JY, Kim SH, Shim BS, Ahn KS.

Phytother Res. 2016 Jun;30(6):1021-32. doi: 10.1002/ptr.5612. Epub 2016 Mar 31.


Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis.

Bi X, Hameed M, Mirani N, Pimenta EM, Anari J, Barnes BJ.

Breast Cancer Res. 2011;13(6):R111. doi: 10.1186/bcr3053. Epub 2011 Nov 4.


Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.

Ruan JW, Liao YC, Lua I, Li MH, Hsu CY, Chen JH.

Breast Cancer Res. 2012 Jul 12;14(4):R106. doi: 10.1186/bcr3226.


Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12.

Douglass S, Meeson AP, Overbeck-Zubrzycka D, Brain JG, Bennett MR, Lamb CA, Lennard TW, Browell D, Ali S, Kirby JA.

J Pathol. 2014 Sep;234(1):74-85. doi: 10.1002/path.4381. Epub 2014 Jul 9.


ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR.

Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum CW, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva FJ, Gustafsson JÅ.

Breast Cancer Res. 2012 Nov 16;14(6):R148. doi: 10.1186/bcr3358.


Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.

Mehta SA, Christopherson KW, Bhat-Nakshatri P, Goulet RJ Jr, Broxmeyer HE, Kopelovich L, Nakshatri H.

Oncogene. 2007 May 17;26(23):3329-37. Epub 2006 Nov 27.


Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis.

Hernandez L, Magalhaes MA, Coniglio SJ, Condeelis JS, Segall JE.

Breast Cancer Res. 2011;13(6):R128. doi: 10.1186/bcr3074. Epub 2011 Dec 9.


ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer.

Appaiah H, Bhat-Nakshatri P, Mehta R, Thorat M, Badve S, Nakshatri H.

Cancer Biol Ther. 2010 Sep 15;10(6):600-14. Epub 2010 Sep 4.


HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells.

Huang S, Ouyang N, Lin L, Chen L, Wu W, Su F, Yao Y, Yao H.

PLoS One. 2012;7(1):e29124. doi: 10.1371/journal.pone.0029124. Epub 2012 Jan 5.


Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis.

Liu F, Zhang H, Song H.

Oncol Rep. 2017 Jan;37(1):83-90. doi: 10.3892/or.2016.5256. Epub 2016 Nov 18.


Inflammatory CXCL12-CXCR4/CXCR7 axis mediates G-protein signaling pathway to influence the invasion and migration of nasopharyngeal carcinoma cells.

Qiao N, Wang L, Wang T, Li H.

Tumour Biol. 2016 Jun;37(6):8169-79. doi: 10.1007/s13277-015-4686-2. Epub 2015 Dec 29.


Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells.

Luker KE, Lewin SA, Mihalko LA, Schmidt BT, Winkler JS, Coggins NL, Thomas DG, Luker GD.

Oncogene. 2012 Nov 8;31(45):4750-8. doi: 10.1038/onc.2011.633. Epub 2012 Jan 23.


An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration.

Park BH, Kook S, Lee S, Jeong JH, Brufsky A, Lee BC.

J Biol Chem. 2013 Oct 4;288(40):28656-67. doi: 10.1074/jbc.M113.509505. Epub 2013 Aug 21.


CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways.

Lian X, Jiao Y, Yang Y, Wang Z, Xuan Q, Liu H, Lu S, Wang Z, Liu Y, Li S, Yang Y, Guo L, Zhao L, Zhang Q.

Med Oncol. 2015 Jan;32(1):411. doi: 10.1007/s12032-014-0411-z. Epub 2014 Dec 5.


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