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Items: 1 to 20 of 112


Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.

Li Y, Sun XX, Elferich J, Shinde U, David LL, Dai MS.

J Biol Chem. 2014 Feb 21;289(8):5097-108. doi: 10.1074/jbc.M113.533109. Epub 2014 Jan 8.


Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.

Sun XX, Challagundla KB, Dai MS.

EMBO J. 2012 Feb 1;31(3):576-92. doi: 10.1038/emboj.2011.434. Epub 2011 Nov 29.


The mechanism of OTUB1-mediated inhibition of ubiquitination.

Wiener R, Zhang X, Wang T, Wolberger C.

Nature. 2012 Feb 22;483(7391):618-22. doi: 10.1038/nature10911.


Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.

Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S.

J Biol Chem. 2012 Jul 27;287(31):25860-8. doi: 10.1074/jbc.M112.364752. Epub 2012 Jun 7.


E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.

Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, Wolberger C.

Nat Struct Mol Biol. 2013 Sep;20(9):1033-9. doi: 10.1038/nsmb.2655. Epub 2013 Aug 18.


Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.

Sun XX, Dai MS.

World J Biol Chem. 2014 May 26;5(2):75-84. doi: 10.4331/wjbc.v5.i2.75. Review.


OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D.

Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Erratum in: Mol Cell. 2012 May 25;46(4):549.


Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria.

Chen Y, Wang YG, Li Y, Sun XX, Dai MS.

Oncotarget. 2017 Feb 14;8(7):11053-11062. doi: 10.18632/oncotarget.14278.


Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis.

Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR.

J Mol Biol. 2015 Apr 24;427(8):1728-47. doi: 10.1016/j.jmb.2014.12.011. Epub 2014 Dec 24.


Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.

Nature. 2010 Aug 19;466(7309):941-6. doi: 10.1038/nature09297.


A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.

Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE.

Mol Cell. 2006 Mar 17;21(6):873-80.


Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL.

J Biol Chem. 2007 Jun 15;282(24):17375-86. Epub 2007 Apr 10.


Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.

Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B.

Mol Cell Biol. 2010 May;30(10):2316-29. doi: 10.1128/MCB.01094-09. Epub 2010 Mar 1.


Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.

Ranaweera RS, Yang X.

J Biol Chem. 2013 Jun 28;288(26):18939-46. doi: 10.1074/jbc.M113.454470. Epub 2013 May 13.


Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase.

Levin I, Eakin C, Blanc MP, Klevit RE, Miller SI, Brzovic PS.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2848-53. doi: 10.1073/pnas.0914821107. Epub 2010 Feb 1.


Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.

Durcan TM, Kontogiannea M, Bedard N, Wing SS, Fon EA.

J Biol Chem. 2012 Jan 2;287(1):531-41. doi: 10.1074/jbc.M111.288449. Epub 2011 Nov 11.


Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.

Suryadinata R, Holien JK, Yang G, Parker MW, Papaleo E, Šarčević B.

Cell Cycle. 2013 Jun 1;12(11):1732-44. doi: 10.4161/cc.24818. Epub 2013 May 8.


Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9. doi: 10.1073/pnas.1407849111. Epub 2014 May 27.


Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT.

Mol Cell Biol. 2000 Nov;20(22):8458-67.


Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates.

Page RC, Pruneda JN, Amick J, Klevit RE, Misra S.

Biochemistry. 2012 May 22;51(20):4175-87. doi: 10.1021/bi300058m. Epub 2012 May 14.

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