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Krüppel-like factor 5 promotes lung tumorigenesis through upregulation of Sox4.

Li Q, Dong Z, Zhou F, Cai X, Gao Y, Wang LW.

Cell Physiol Biochem. 2014;33(1):1-10. doi: 10.1159/000356645. Epub 2014 Jan 2.


Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.

Zheng HQ, Zhou Z, Huang J, Chaudhury L, Dong JT, Chen C.

Oncogene. 2009 Oct 22;28(42):3702-13. doi: 10.1038/onc.2009.235. Epub 2009 Aug 10.


Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.

Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL.

Am J Pathol. 2010 Sep;177(3):1503-13. doi: 10.2353/ajpath.2010.090651. Epub 2010 Jul 16.


KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.

Li X, Liu X, Xu Y, Liu J, Xie M, Ni W, Chen S.

Int J Oncol. 2014 Oct;45(4):1507-14. doi: 10.3892/ijo.2014.2544. Epub 2014 Jul 17.


Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients.

Zhou Y, Wang X, Huang Y, Chen Y, Zhao G, Yao Q, Jin C, Huang Y, Liu X, Li G.

J Cell Biochem. 2015 Jun;116(6):1007-18. doi: 10.1002/jcb.25055.


Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells.

Goldstein BG, Chao HH, Yang Y, Yermolina YA, Tobias JW, Katz JP.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1784-92. Epub 2007 Mar 29.


Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer.

Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C.

J Biol Chem. 2013 Sep 13;288(37):26731-40. doi: 10.1074/jbc.M113.483958. Epub 2013 Aug 2.


KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line.

Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY, Bao Y, Zhou Z, Cheng X, Simons JW, Dong JT.

Int J Cancer. 2006 Mar 15;118(6):1346-55.


KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.

Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C.

J Biol Chem. 2009 Jun 19;284(25):16791-8. doi: 10.1074/jbc.M808919200. Epub 2009 May 1.


Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer.

Castillo SD, Matheu A, Mariani N, Carretero J, Lopez-Rios F, Lovell-Badge R, Sanchez-Cespedes M.

Cancer Res. 2012 Jan 1;72(1):176-86. doi: 10.1158/0008-5472.CAN-11-3506. Epub 2011 Nov 14.


Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.

Nandan MO, Ghaleb AM, Liu Y, Bialkowska AB, McConnell BB, Shroyer KR, Robine S, Yang VW.

Dev Biol. 2014 Mar 15;387(2):191-202. doi: 10.1016/j.ydbio.2014.01.002. Epub 2014 Jan 15.


Krüppel-like factor 5 promotes apoptosis triggered by tumor necrosis factor α in LNCaP prostate cancer cells via up-regulation of mitogen-activated protein kinase kinase 7.

Shi Q, Gao Y, Xu S, Du C, Li F, Tang XS, Jia J, Wang X, Chang L, He D, Guo P.

Urol Oncol. 2016 Feb;34(2):58.e11-8. doi: 10.1016/j.urolonc.2015.09.004. Epub 2015 Oct 21.


Estrogen induces androgen-repressed SOX4 expression to promote progression of prostate cancer cells.

Yang M, Wang J, Wang L, Shen C, Su B, Qi M, Hu J, Gao W, Tan W, Han B.

Prostate. 2015 Sep;75(13):1363-75. doi: 10.1002/pros.23017. Epub 2015 May 27.


Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.

Mori A, Moser C, Lang SA, Hackl C, Gottfried E, Kreutz M, Schlitt HJ, Geissler EK, Stoeltzing O.

Mol Cancer Res. 2009 Aug;7(8):1390-8. doi: 10.1158/1541-7786.MCR-08-0525. Epub 2009 Aug 11.


Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells.

Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS.

Cancer Res. 2009 Jan 15;69(2):709-17. doi: 10.1158/0008-5472.CAN-08-3415.


SOX4 transcriptionally regulates multiple SEMA3/plexin family members and promotes tumor growth in pancreatic cancer.

Huang HY, Cheng YY, Liao WC, Tien YW, Yang CH, Hsu SM, Huang PH.

PLoS One. 2012;7(12):e48637. doi: 10.1371/journal.pone.0048637. Epub 2012 Dec 12.


The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.

Matsumura T, Suzuki T, Aizawa K, Munemasa Y, Muto S, Horikoshi M, Nagai R.

J Biol Chem. 2005 Apr 1;280(13):12123-9. Epub 2005 Jan 24. Erratum in: J Biol Chem. 2005 May 13;280(19):19436.


Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta.

Guo P, Dong XY, Zhao K, Sun X, Li Q, Dong JT.

J Biol Chem. 2009 Oct 9;284(41):28243-52. doi: 10.1074/jbc.M109.036160. Epub 2009 Aug 14.


Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis.

Suzuki T, Sawaki D, Aizawa K, Munemasa Y, Matsumura T, Ishida J, Nagai R.

J Biol Chem. 2009 Apr 3;284(14):9549-57. doi: 10.1074/jbc.M806230200. Epub 2009 Feb 3.

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