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Items: 1 to 20 of 91

1.

Noninvasive quantification of metabotropic glutamate receptor type 1 with [¹¹C]ITDM: a small-animal PET study.

Yamasaki T, Fujinaga M, Yui J, Ikoma Y, Hatori A, Xie L, Wakizaka H, Kumata K, Nengaki N, Kawamura K, Zhang MR.

J Cereb Blood Flow Metab. 2014 Apr;34(4):606-12. doi: 10.1038/jcbfm.2013.243. Epub 2014 Jan 8.

2.

In vivo measurement of the affinity and density of metabotropic glutamate receptor subtype 1 in rat brain using 18F-FITM in small-animal PET.

Yamasaki T, Fujinaga M, Kawamura K, Yui J, Hatori A, Ohya T, Xie L, Wakizaka H, Yoshida Y, Fukumura T, Zhang MR.

J Nucl Med. 2012 Oct;53(10):1601-7. doi: 10.2967/jnumed.112.105908. Epub 2012 Aug 22.

3.

Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain.

Fujinaga M, Yamasaki T, Yui J, Hatori A, Xie L, Kawamura K, Asagawa C, Kumata K, Yoshida Y, Ogawa M, Nengaki N, Fukumura T, Zhang MR.

J Med Chem. 2012 Mar 8;55(5):2342-52. doi: 10.1021/jm201590g. Epub 2012 Feb 24.

PMID:
22316010
4.

Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.

Yamasaki T, Fujinaga M, Kawamura K, Furutsuka K, Nengaki N, Shimoda Y, Shiomi S, Takei M, Hashimoto H, Yui J, Wakizaka H, Hatori A, Xie L, Kumata K, Zhang MR.

J Neurosci. 2016 Jan 13;36(2):375-84. doi: 10.1523/JNEUROSCI.2289-15.2016.

5.

Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain.

Fujinaga M, Yamasaki T, Maeda J, Yui J, Xie L, Nagai Y, Nengaki N, Hatori A, Kumata K, Kawamura K, Zhang MR.

J Med Chem. 2012 Dec 27;55(24):11042-51. doi: 10.1021/jm301597s. Epub 2012 Dec 10.

PMID:
23194448
6.

Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET.

Yamasaki T, Fujinaga M, Yui J, Wakizaka H, Ohya T, Nengaki N, Ogawa M, Ikoma Y, Hatori A, Xie L, Kawamura K, Zhang MR.

PLoS One. 2015 Jun 15;10(6):e0130006. doi: 10.1371/journal.pone.0130006. eCollection 2015.

7.

Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1.

Yamasaki T, Fujinaga M, Yoshida Y, Kumata K, Yui J, Kawamura K, Hatori A, Fukumura T, Zhang MR.

Bioorg Med Chem Lett. 2011 May 15;21(10):2998-3001. doi: 10.1016/j.bmcl.2011.03.046. Epub 2011 Mar 17.

PMID:
21470858
8.

[carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain.

Hong J, Lu S, Xu R, Liow JS, Woock AE, Jenko KJ, Gladding RL, Zoghbi SS, Innis RB, Pike VW.

Nucl Med Biol. 2015 Dec;42(12):967-74. doi: 10.1016/j.nucmedbio.2015.07.006. Epub 2015 Jul 23.

9.

N-(4-(6-(Isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methyl-4-[11C]methylbenzamide.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2013 Feb 19 [updated 2013 May 2].

10.

PET brain kinetics studies of (11)C-ITMM and (11)C-ITDM,radioprobes for metabotropic glutamate receptor type 1, in a nonhuman primate.

Yamasaki T, Maeda J, Fujinaga M, Nagai Y, Hatori A, Yui J, Xie L, Nengaki N, Zhang MR.

Am J Nucl Med Mol Imaging. 2014 Apr 25;4(3):260-9. eCollection 2014.

11.

Decreased metabotropic glutamate receptor type 1 availability in a patient with spinocerebellar ataxia type 6: A (11)C-ITMM PET study.

Ishibashi K, Miura Y, Ishikawa K, Ishii K, Ishiwata K.

J Neurol Sci. 2015 Aug 15;355(1-2):202-5. doi: 10.1016/j.jns.2015.05.041. Epub 2015 Jun 3.

PMID:
26055313
12.

Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM.

Yamasaki T, Fujinaga M, Maeda J, Kawamura K, Yui J, Hatori A, Yoshida Y, Nagai Y, Tokunaga M, Higuchi M, Suhara T, Fukumura T, Zhang MR.

Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):632-41. doi: 10.1007/s00259-011-1995-6. Epub 2011 Nov 24.

PMID:
22113620
13.

Preclinical and the first clinical studies on [11C]ITMM for mapping metabotropic glutamate receptor subtype 1 by positron emission tomography.

Toyohara J, Sakata M, Fujinaga M, Yamasaki T, Oda K, Ishii K, Zhang MR, Moriguchi Jeckel CM, Ishiwata K.

Nucl Med Biol. 2013 Feb;40(2):214-20. doi: 10.1016/j.nucmedbio.2012.11.008. Epub 2012 Dec 21.

PMID:
23265669
14.

Initial human PET studies of metabotropic glutamate receptor type 1 ligand 11C-ITMM.

Toyohara J, Sakata M, Oda K, Ishii K, Ito K, Hiura M, Fujinaga M, Yamasaki T, Zhang MR, Ishiwata K.

J Nucl Med. 2013 Aug;54(8):1302-7. doi: 10.2967/jnumed.113.119891. Epub 2013 Jun 26.

15.

Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains.

Fujinaga M, Maeda J, Yui J, Hatori A, Yamasaki T, Kawamura K, Kumata K, Yoshida Y, Nagai Y, Higuchi M, Suhara T, Fukumura T, Zhang MR.

J Neurochem. 2012 Apr;121(1):115-24. doi: 10.1111/j.1471-4159.2011.07348.x. Epub 2011 Jul 1.

16.

Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1.

Yanamoto K, Konno F, Odawara C, Yamasaki T, Kawamura K, Hatori A, Yui J, Wakizaka H, Nengaki N, Takei M, Zhang MR.

Nucl Med Biol. 2010 Jul;37(5):615-24. doi: 10.1016/j.nucmedbio.2010.03.002. Epub 2010 Apr 24.

PMID:
20610166
17.

N-(4-(6-(Isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-4-[11C]methoxy-N-methylbenzamide.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2013 Feb 14 [updated 2013 May 2].

18.

N-acetylcysteine- and MK-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain.

Wyckhuys T, Verhaeghe J, Wyffels L, Langlois X, Schmidt M, Stroobants S, Staelens S.

J Nucl Med. 2013 Nov;54(11):1954-61. doi: 10.2967/jnumed.113.121608. Epub 2013 Sep 19.

19.

Monitoring neuroprotective effects using positron emission tomography with [11C]ITMM, a radiotracer for metabotropic glutamate 1 receptor.

Yui J, Xie L, Fujinaga M, Yamasaki T, Hatori A, Kumata K, Nengaki N, Zhang MR.

Stroke. 2013 Sep;44(9):2567-72. doi: 10.1161/STROKEAHA.113.001178. Epub 2013 Aug 1.

20.

Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4).

Fujinaga M, Yamasaki T, Nengaki N, Ogawa M, Kumata K, Shimoda Y, Yui J, Xie L, Zhang Y, Kawamura K, Zhang MR.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4. doi: 10.1016/j.bmcl.2015.12.008. Epub 2015 Dec 7.

PMID:
26707390

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