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Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy.

Yang L, Rozenfeld R, Wu D, Devi LA, Zhang Z, Cederbaum A.

Free Radic Biol Med. 2014 Mar;68:260-7. doi: 10.1016/j.freeradbiomed.2013.12.026. Epub 2014 Jan 4.


Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy.

Wu D, Wang X, Zhou R, Yang L, Cederbaum AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1346-57. doi: 10.1016/j.freeradbiomed.2012.07.005. Epub 2012 Jul 20.


Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.

Yang L, Wu D, Wang X, Cederbaum AI.

Free Radic Biol Med. 2012 Sep 1;53(5):1170-80. doi: 10.1016/j.freeradbiomed.2012.06.029. Epub 2012 Jun 27.


Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.

Zhou R, Lin J, Wu D.

Biochim Biophys Acta. 2014 Jan;1840(1):209-18. doi: 10.1016/j.bbagen.2013.09.018. Epub 2013 Sep 21.


Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.

Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C.

Oncotarget. 2015 Dec 8;6(39):41464-78. doi: 10.18632/oncotarget.6203.


Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease.

Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC.

Dis Model Mech. 2013 Sep;6(5):1213-26. doi: 10.1242/dmm.012195. Epub 2013 Jun 20.


CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells.

Wu D, Wang X, Zhou R, Cederbaum A.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):116-22. doi: 10.1016/j.bbrc.2010.09.127. Epub 2010 Oct 12.


Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity.

Lu Y, Cederbaum AI.

Biomolecules. 2015 Oct 16;5(4):2659-74. doi: 10.3390/biom5042659.


CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway.

Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ.

PLoS One. 2014 Jun 3;9(6):e98658. doi: 10.1371/journal.pone.0098658. eCollection 2014.


Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy.

Guo R, Xu X, Babcock SA, Zhang Y, Ren J.

J Hepatol. 2015 Mar;62(3):647-56. doi: 10.1016/j.jhep.2014.10.009. Epub 2014 Oct 20.


Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation.

Dai N, Zou Y, Zhu L, Wang HF, Dai MG.

J Med Food. 2014 Jun;17(6):663-9. doi: 10.1089/jmf.2013.2834. Epub 2014 Apr 8.


Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.

Wang X, Wu D, Yang L, Gan L, Cederbaum AI.

Free Radic Biol Med. 2013 Oct;63:175-86. doi: 10.1016/j.freeradbiomed.2013.05.009. Epub 2013 May 10.


Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.

Ni HM, Bhakta A, Wang S, Li Z, Manley S, Huang H, Copple B, Ding WX.

PLoS One. 2014 Dec 23;9(12):e115849. doi: 10.1371/journal.pone.0115849. eCollection 2014.


Oral or intraperitoneal binge drinking and oxidative balance in adolescent rats.

Nogales F, Rua RM, Ojeda ML, Murillo ML, Carreras O.

Chem Res Toxicol. 2014 Nov 17;27(11):1926-33. doi: 10.1021/tx5002628. Epub 2014 Nov 5.


Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice.

Zhang P, Ma D, Wang Y, Zhang M, Qiang X, Liao M, Liu X, Wu H, Zhang Y.

Food Chem Toxicol. 2014 Dec;74:225-32.


Endoplasmic reticulum stress-mediated autophagy activation attenuates fumonisin B1 induced hepatotoxicity in vitro and in vivo.

Singh MP, Kang SC.

Food Chem Toxicol. 2017 Dec;110:371-382. doi: 10.1016/j.fct.2017.10.054. Epub 2017 Oct 31.


Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.

Wang S, Ni HM, Dorko K, Kumer SC, Schmitt TM, Nawabi A, Komatsu M, Huang H, Ding WX.

Oncotarget. 2016 Apr 5;7(14):17681-98. doi: 10.18632/oncotarget.6893.


Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues.

Zhao YY, Yang R, Xiao M, Guan MJ, Zhao N, Zeng T.

Toxicology. 2017 Sep 1;390:53-60. doi: 10.1016/j.tox.2017.09.001. Epub 2017 Sep 4.


Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.

Cederbaum AI.

Dig Dis. 2010;28(6):802-11. doi: 10.1159/000324289. Epub 2011 Apr 27.

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