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N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms.

Zhang Y, Chen G, Zhong S, Zheng F, Gao F, Chen Y, Huang Z, Cai W, Li W, Liu X, Zheng Y, Xu H, Shi G.

Oxid Med Cell Longev. 2013;2013:912310. doi: 10.1155/2013/912310. Epub 2013 Nov 12.


N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity.

Wang JZ, Cai CY, Zhang YM, Zheng JH, Chen YC, Li WQ, Shi GG.

Biochem Pharmacol. 2010 May 15;79(10):1428-36. doi: 10.1016/j.bcp.2010.01.021. Epub 2010 Jan 25.


Effects of N-n-butyl haloperidol iodide on myocardial ischemia/reperfusion injury and Egr-1 expression in rat.

Zhang YM, Shi GG, Tang Z, Zheng JH, Li WQ, Guo FX, Jia QY.

Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):435-41.


Egr-1, a central and unifying role in cardioprotection from ischemia-reperfusion injury?

Gao FF, Jia QY, Guo FX, Zhang YM, Huang ZQ, Zhou YQ, Chen YC, Shi GG.

Cell Physiol Biochem. 2009;24(5-6):519-26. doi: 10.1159/000257497. Epub 2009 Nov 4.


The protective effects of N-n-butyl haloperidol iodide on myocardial ischemia-reperfusion injury in rats by inhibiting Egr-1 overexpression.

Zhang Y, Shi G, Zheng J, Tang Z, Gao P, Lv Y, Guo F, Jia Q.

Cell Physiol Biochem. 2007;20(5):639-48.


Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation.

Zhang Y, Liao H, Zhong S, Gao F, Chen Y, Huang Z, Lu S, Sun T, Wang B, Li W, Xu H, Zheng F, Shi G.

Sci Rep. 2015 Jul 2;5:11809. doi: 10.1038/srep11809.


Remifentanil preconditioning protects rat cardiomyocytes against hypoxia-reoxygenation injury via δ-opioid receptor mediated activation of PI3K/Akt and ERK pathways.

Dou MY, Wu H, Zhu HJ, Jin SY, Zhang Y, He SF.

Eur J Pharmacol. 2016 Oct 15;789:395-401. doi: 10.1016/j.ejphar.2016.08.002. Epub 2016 Aug 2.


The protective effect of Egr-1 antisense oligodeoxyribonucleotide on myocardial injury induced by ischemia-reperfusion and hypoxia-reoxygenation.

Zhang Y, Shi G, Zheng J, Lv Y, Gao P, Huang Z, Gao F, Zhou Y.

Cell Physiol Biochem. 2008;22(5-6):645-52. doi: 10.1159/000185548. Epub 2008 Dec 9.


N-n-butyl haloperidol iodide protects cardiac microvascular endothelial cells from hypoxia/reoxygenation injury by down-regulating Egr-1 expression.

Zhou Y, Zhang Y, Gao F, Guo F, Wang J, Cai W, Chen Y, Zheng J, Shi G.

Cell Physiol Biochem. 2010;26(6):839-48. doi: 10.1159/000323993. Epub 2011 Jan 4.


N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy.

Wang B, Zhong S, Zheng F, Zhang Y, Gao F, Chen Y, Lu B, Xu H, Shi G.

Oncotarget. 2015 Sep 22;6(28):24709-21. doi: 10.18632/oncotarget.5077.


Allopurinol modulates reactive oxygen species generation and Ca2+ overload in ischemia-reperfused heart and hypoxia-reoxygenated cardiomyocytes.

Kang SM, Lim S, Song H, Chang W, Lee S, Bae SM, Chung JH, Lee H, Kim HG, Yoon DH, Kim TW, Jang Y, Sung JM, Chung NS, Hwang KC.

Eur J Pharmacol. 2006 Mar 27;535(1-3):212-9. Epub 2006 Mar 6.


N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway.

Lu S, Zhang Y, Zhong S, Gao F, Chen Y, Li W, Zheng F, Shi G.

Front Pharmacol. 2017 Jan 5;7:520. doi: 10.3389/fphar.2016.00520. eCollection 2016.


Nitric oxide preserves XIAP and reduces hypoxia/reoxygenation-induced cardiomyocytes apoptosis via ERK1/2 activation.

Yuan H, Yan B, Wang HH, Hua S, Hu A.

Biochem Biophys Res Commun. 2012 Apr 27;421(1):134-9. doi: 10.1016/j.bbrc.2012.03.138. Epub 2012 Apr 4.


N-n-Butyl haloperidol iodide inhibits the augmented Na+/Ca2+ exchanger currents and L-type Ca2+ current induced by hypoxia/reoxygenation or H2O2 in cardiomyocytes.

Huang Y, Gao F, Zhang Y, Chen Y, Wang B, Zheng Y, Shi G.

Biochem Biophys Res Commun. 2012 Apr 27;421(1):86-90. doi: 10.1016/j.bbrc.2012.03.119. Epub 2012 Apr 2.


Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation.

Liu Q, Wang J, Liang Q, Wang D, Luo Y, Li J, Janicki JS, Fan D.

Exp Biol Med (Maywood). 2014 Mar;239(3):376-84. doi: 10.1177/1535370213517620. Epub 2014 Jan 29.


N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes.

Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG.

Drug Des Devel Ther. 2014 Sep 9;8:1257-67. doi: 10.2147/DDDT.S63163. eCollection 2014.


The effects of quercetin protect cardiomyocytes from A/R injury is related to its capability to increasing expression and activity of PKCε protein.

Tang L, Peng Y, Xu T, Yi X, Liu Y, Luo Y, Yin D, He M.

Mol Cell Biochem. 2013 Oct;382(1-2):145-52. doi: 10.1007/s11010-013-1729-0. Epub 2013 Jun 23.


Mechanisms of vitexin preconditioning effects on cultured neonatal rat cardiomyocytes with anoxia and reoxygenation.

Dong LY, Chen ZW, Guo Y, Cheng XP, Shao X.

Am J Chin Med. 2008;36(2):385-97.


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