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Items: 1 to 20 of 104

1.

Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.

Siveen KS, Sikka S, Surana R, Dai X, Zhang J, Kumar AP, Tan BK, Sethi G, Bishayee A.

Biochim Biophys Acta. 2014 Apr;1845(2):136-54. doi: 10.1016/j.bbcan.2013.12.005. Review.

PMID:
24388873
2.

Role of STAT3 in cancer metastasis and translational advances.

Kamran MZ, Patil P, Gude RP.

Biomed Res Int. 2013;2013:421821. doi: 10.1155/2013/421821. Review.

3.

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT.

Oncogene. 2016 Feb 11;35(6):783-92. doi: 10.1038/onc.2015.215. Erratum in: Oncogene. 2016 Feb 11;35(6):802.

PMID:
26073084
4.

STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma.

Klein JD, Sano D, Sen M, Myers JN, Grandis JR, Kim S.

PLoS One. 2014 Jan 3;9(1):e81819. doi: 10.1371/journal.pone.0081819.

5.

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model.

Shanmugam MK, Rajendran P, Li F, Kim C, Sikka S, Siveen KS, Kumar AP, Ahn KS, Sethi G.

Mol Carcinog. 2015 Oct;54(10):971-85. doi: 10.1002/mc.22166.

PMID:
24797723
6.

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.

Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x.

7.

β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.

Kim C, Cho SK, Kapoor S, Kumar A, Vali S, Abbasi T, Kim SH, Sethi G, Ahn KS.

Mol Carcinog. 2014 Oct;53(10):793-806. doi: 10.1002/mc.22035.

PMID:
23765383
8.

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.

Heo JY, Kim HJ, Kim SM, Park KR, Park SY, Kim SW, Nam D, Jang HJ, Lee SG, Ahn KS, Kim SH, Shim BS, Choi SH, Ahn KS.

Cancer Lett. 2011 Sep 1;308(1):71-80. doi: 10.1016/j.canlet.2011.04.015.

PMID:
21565443
9.

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion.

Huang W, Dong Z, Wang F, Peng H, Liu JY, Zhang JT.

ACS Chem Biol. 2014 May 16;9(5):1188-96. doi: 10.1021/cb500071v.

10.

STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo.

Huang C, Jiang T, Zhu L, Liu J, Cao J, Huang KJ, Qiu ZJ.

Int J Oncol. 2011 Jun;38(6):1637-44. doi: 10.3892/ijo.2011.1000.

PMID:
21479358
11.

STAT proteins: novel molecular targets for cancer drug discovery.

Turkson J, Jove R.

Oncogene. 2000 Dec 27;19(56):6613-26. Review.

12.

Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway.

Lin W, Zheng L, Zhuang Q, Zhao J, Cao Z, Zeng J, Lin S, Xu W, Peng J.

BMC Complement Altern Med. 2013 Jun 24;13:144. doi: 10.1186/1472-6882-13-144.

13.

C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment.

Wani N, Nasser MW, Ahirwar DK, Zhao H, Miao Z, Shilo K, Ganju RK.

Breast Cancer Res. 2014 May 29;16(3):R54. doi: 10.1186/bcr3665.

14.

Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer.

Santoni M, Massari F, Del Re M, Ciccarese C, Piva F, Principato G, Montironi R, Santini D, Danesi R, Tortora G, Cascinu S.

Expert Opin Investig Drugs. 2015 Jun;24(6):809-24. doi: 10.1517/13543784.2015.1020370. Review.

PMID:
25746129
15.

miR-21: A gene of dual regulation in breast cancer.

Zhang C, Liu K, Li T, Fang J, Ding Y, Sun L, Tu T, Jiang X, Du S, Hu J, Zhu W, Chen H, Sun X.

Int J Oncol. 2016 Jan;48(1):161-72. doi: 10.3892/ijo.2015.3232.

PMID:
26549725
16.

Constitutive activation of STAT3 in breast cancer cells: A review.

Banerjee K, Resat H.

Int J Cancer. 2016 Jun 1;138(11):2570-8. doi: 10.1002/ijc.29923. Review.

PMID:
26559373
17.

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.

J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954.

PMID:
21792937
18.

Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway.

Wang J, Zhang L, Chen G, Zhang J, Li Z, Lu W, Liu M, Pang X.

Breast Cancer Res Treat. 2014 Nov;148(2):279-89. doi: 10.1007/s10549-014-3165-6.

PMID:
25301089
19.

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review).

Wang X, Crowe PJ, Goldstein D, Yang JL.

Int J Oncol. 2012 Oct;41(4):1181-91. doi: 10.3892/ijo.2012.1568. Review.

PMID:
22842992
20.
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