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Items: 1 to 20 of 116

1.

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.

Demchuk DV, Samet AV, Chernysheva NB, Ushkarov VI, Stashina GA, Konyushkin LD, Raihstat MM, Firgang SI, Philchenkov AA, Zavelevich MP, Kuiava LM, Chekhun VF, Blokhin DY, Kiselyov AS, Semenova MN, Semenov VV.

Bioorg Med Chem. 2014 Jan 15;22(2):738-55. doi: 10.1016/j.bmc.2013.12.015.

PMID:
24387982
2.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2010 May 27;53(10):4248-58. doi: 10.1021/jm100245q.

3.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008.

PMID:
25192811
4.

cis-Restricted 3-aminopyrazole analogues of combretastatins: synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays.

Tsyganov DV, Konyushkin LD, Karmanova IB, Firgang SI, Strelenko YA, Semenova MN, Kiselyov AS, Semenov VV.

J Nat Prod. 2013 Aug 23;76(8):1485-91. doi: 10.1021/np400310m.

PMID:
23924236
5.

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

Kiselyov AS, Semenova MN, Chernyshova NB, Leitao A, Samet AV, Kislyi KA, Raihstat MM, Oprea T, Lemcke H, Lantow M, Weiss DG, Ikizalp NN, Kuznetsov SA, Semenov VV.

Eur J Med Chem. 2010 May;45(5):1683-97. doi: 10.1016/j.ejmech.2009.12.072.

PMID:
20110137
6.

Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.

Semenova MN, Tsyganov DV, Malyshev OR, Ershov OV, Bardasov IN, Semenov RV, Kiselyov AS, Semenov VV.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3914-8. doi: 10.1016/j.bmcl.2014.06.043. Erratum in: Bioorg Med Chem Lett. 2015 Apr 1;25(7):1653-4.

PMID:
24997684
7.

Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.

Semenova MN, Kiselyov AS, Tsyganov DV, Konyushkin LD, Firgang SI, Semenov RV, Malyshev OR, Raihstat MM, Fuchs F, Stielow A, Lantow M, Philchenkov AA, Zavelevich MP, Zefirov NS, Kuznetsov SA, Semenov VV.

J Med Chem. 2011 Oct 27;54(20):7138-49. doi: 10.1021/jm200737s.

PMID:
21916509
8.

3-(5-)-Amino-o-diarylisoxazoles: regioselective synthesis and antitubulin activity.

Tsyganov DV, Khrustalev VN, Konyushkin LD, Raihstat MM, Firgang SI, Semenov RV, Kiselyov AS, Semenova MN, Semenov VV.

Eur J Med Chem. 2014 Feb 12;73:112-25. doi: 10.1016/j.ejmech.2013.12.006.

PMID:
24388833
9.

2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

Raffa D, Maggio B, Raimondi MV, Cusimano MG, Amico G, Carollo A, Conaldi PG, Bai R, Hamel E, Daidone G.

Eur J Med Chem. 2013 Jul;65:427-35. doi: 10.1016/j.ejmech.2013.04.068.

10.

Discovery of azaisoerianin derivatives as potential antitumors agents.

Soussi MA, Provot O, Bernadat G, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.

Eur J Med Chem. 2014 May 6;78:178-89. doi: 10.1016/j.ejmech.2014.03.032.

PMID:
24681982
11.

Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives.

Kandeel MM, Refaat HM, Kassab AE, Shahin IG, Abdelghany TM.

Eur J Med Chem. 2015 Jan 27;90:620-32. doi: 10.1016/j.ejmech.2014.12.009.

PMID:
25499930
12.

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs.

Banimustafa M, Kheirollahi A, Safavi M, Kabudanian Ardestani S, Aryapour H, Foroumadi A, Emami S.

Eur J Med Chem. 2013;70:692-702. doi: 10.1016/j.ejmech.2013.10.046.

PMID:
24219991
13.

Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents.

Duan YC, Ma YC, Zhang E, Shi XJ, Wang MM, Ye XW, Liu HM.

Eur J Med Chem. 2013 Apr;62:11-9. doi: 10.1016/j.ejmech.2012.12.046.

PMID:
23353743
14.

Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids.

Duan YC, Zheng YC, Li XC, Wang MM, Ye XW, Guan YY, Liu GZ, Zheng JX, Liu HM.

Eur J Med Chem. 2013 Jun;64:99-110. doi: 10.1016/j.ejmech.2013.03.058.

PMID:
23644193
15.

Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents.

Ma LY, Pang LP, Wang B, Zhang M, Hu B, Xue DQ, Shao KP, Zhang BL, Liu Y, Zhang E, Liu HM.

Eur J Med Chem. 2014 Oct 30;86:368-80. doi: 10.1016/j.ejmech.2014.08.010.

PMID:
25180925
16.

Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin.

Dias TA, Duarte CL, Lima CF, Proença MF, Pereira-Wilson C.

Eur J Med Chem. 2013 Jul;65:500-10. doi: 10.1016/j.ejmech.2013.04.064.

PMID:
23771043
17.

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.

Sriram M, Hall JJ, Grohmann NC, Strecker TE, Wootton T, Franken A, Trawick ML, Pinney KG.

Bioorg Med Chem. 2008 Sep 1;16(17):8161-71. doi: 10.1016/j.bmc.2008.07.050.

PMID:
18722127
18.

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

Carr M, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ.

Eur J Med Chem. 2010 Dec;45(12):5752-66. doi: 10.1016/j.ejmech.2010.09.033.

PMID:
20933304
19.

Polyalkoxy substituted 4H-chromenes: synthesis by domino reaction and anticancer activity.

Shestopalov AM, Litvinov YM, Rodinovskaya LA, Malyshev OR, Semenova MN, Semenov VV.

ACS Comb Sci. 2012 Aug 13;14(8):484-90. doi: 10.1021/co300062e.

PMID:
22824131
20.

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies.

Senwar KR, Sharma P, Reddy TS, Jeengar MK, Nayak VL, Naidu VG, Kamal A, Shankaraiah N.

Eur J Med Chem. 2015 Sep 18;102:413-24. doi: 10.1016/j.ejmech.2015.08.017.

PMID:
26301558
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