Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 74

1.

Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.

Waldmann T, Rempel E, Balmer NV, König A, Kolde R, Gaspar JA, Henry M, Hescheler J, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Chem Res Toxicol. 2014 Mar 17;27(3):408-20. doi: 10.1021/tx400402j. Epub 2014 Jan 21.

2.

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Waldmann T, Grinberg M, König A, Rempel E, Schildknecht S, Henry M, Holzer AK, Dreser N, Shinde V, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.

PMID:
28001369
3.

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.

Balmer NV, Klima S, Rempel E, Ivanova VN, Kolde R, Weng MK, Meganathan K, Henry M, Sachinidis A, Berthold MR, Hengstler JG, Rahnenführer J, Waldmann T, Leist M.

Arch Toxicol. 2014 Jul;88(7):1451-68. doi: 10.1007/s00204-014-1279-6. Epub 2014 Jun 17.

4.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach.

Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause KH, Hengstler JG, Rahnenführer J, Leist M, Sachinidis A.

Arch Toxicol. 2013 Jan;87(1):123-43. doi: 10.1007/s00204-012-0967-3. Epub 2012 Nov 21.

5.

Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons.

Ehashi T, Suzuki N, Ando S, Sumida K, Saito K.

J Toxicol Sci. 2014 Jun;39(3):383-90.

6.

Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells.

Jergil M, Forsberg M, Salter H, Stockling K, Gustafson AL, Dencker L, Stigson M.

Toxicol Sci. 2011 Jun;121(2):328-42. doi: 10.1093/toxsci/kfr070. Epub 2011 Apr 6.

PMID:
21427059
7.

A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system.

Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Zagoura D, Bremer S, Sachinidis A, Lazzari G.

Toxicol Lett. 2014 Nov 18;231(1):38-44. doi: 10.1016/j.toxlet.2014.08.023. Epub 2014 Sep 2.

PMID:
25192806
8.

Characterisation of a neural teratogenicity assay based on human ESCs differentiation following exposure to valproic acid.

Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Sachinidis A, Lazzari G.

Curr Med Chem. 2012;19(35):6065-71.

PMID:
23061626
9.
10.

Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).

Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH.

Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/toxsci/kfr293. Epub 2011 Nov 1.

PMID:
22045034
11.

Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Schulpen SH, Pennings JL, Piersma AH.

Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.

PMID:
25979313
12.

A novel embryotoxic estimation method of VPA using ES cells differentiation system.

Murabe M, Yamauchi J, Fujiwara Y, Hiroyama M, Sanbe A, Tanoue A.

Biochem Biophys Res Commun. 2007 Jan 5;352(1):164-9. Epub 2006 Nov 13.

PMID:
17112465
13.

Transcriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicants.

Gao X, Yourick JJ, Sprando RL.

PLoS One. 2014 Sep 23;9(9):e108510. doi: 10.1371/journal.pone.0108510. eCollection 2014.

14.
15.

Predicting distinct organization of transcription factor binding sites on the promoter regions: a new genome-based approach to expand human embryonic stem cell regulatory network.

Hosseinpour B, Bakhtiarizadeh MR, Khosravi P, Ebrahimie E.

Gene. 2013 Dec 1;531(2):212-9. doi: 10.1016/j.gene.2013.09.011. Epub 2013 Sep 13.

PMID:
24042128
16.

Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol.

Schulpen SH, de Jong E, de la Fonteyne LJ, de Klerk A, Piersma AH.

Toxicol In Vitro. 2015 Apr;29(3):449-57. doi: 10.1016/j.tiv.2014.12.001. Epub 2014 Dec 15.

PMID:
25524013
17.

Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure.

Schulpen SH, Theunissen PT, Pennings JL, Piersma AH.

Reprod Toxicol. 2015 Aug 15;56:77-86. doi: 10.1016/j.reprotox.2015.06.043. Epub 2015 Jun 11.

PMID:
26072468
18.

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.

van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH.

Toxicol Appl Pharmacol. 2011 Mar 1;251(2):110-8. doi: 10.1016/j.taap.2010.12.008. Epub 2010 Dec 28.

PMID:
21192963
19.
20.

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.

Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stöber R, Marchan R, van Thriel C, Liebing J, Meisig J, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Arch Toxicol. 2015 Sep;89(9):1599-618. doi: 10.1007/s00204-015-1573-y. Epub 2015 Aug 14.

Supplemental Content

Support Center