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Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53.

Meng X, Dizon DS, Yang S, Wang X, Zhu D, Thiel KW, Leslie KK.

Obstet Gynecol Int. 2013;2013:828165. doi: 10.1155/2013/828165. Epub 2013 Dec 7.


Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53.

Meng X, Laidler LL, Kosmacek EA, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey MA, Leslie KK.

Gynecol Oncol. 2013 Mar;128(3):461-9. doi: 10.1016/j.ygyno.2012.11.004. Epub 2012 Nov 9.


Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.

Vera J, Raatz Y, Wolkenhauer O, Kottek T, Bhattacharya A, Simon JC, Kunz M.

Cell Signal. 2015 May;27(5):951-60. doi: 10.1016/j.cellsig.2015.01.020. Epub 2015 Feb 12.


Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.

Luo W, Wu F, Elmaoued R, Beck BB, Fischer E, Meng X, Leslie KK, Dai D.

Int J Oncol. 2010 Nov;37(5):1187-94.


UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.

J Natl Cancer Inst. 1996 Jul 17;88(14):956-65.


Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation.

Rakovitch E, Mellado W, Hall EJ, Pandita TK, Sawant S, Geard CR.

Int J Radiat Oncol Biol Phys. 1999 Jul 15;44(5):1119-24.


90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.

Tse AN, Sheikh TN, Alan H, Chou TC, Schwartz GK.

Mol Pharmacol. 2009 Jan;75(1):124-33. doi: 10.1124/mol.108.050807. Epub 2008 Sep 26.


Epothilone induced cytotoxicity is dependent on p53 status in prostate cells.

Ioffe ML, White E, Nelson DA, Dvorzhinski D, DiPaola RS.

Prostate. 2004 Nov 1;61(3):243-7.


Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics.

Xiao Z, Xue J, Semizarov D, Sowin TJ, Rosenberg SH, Zhang H.

Int J Cancer. 2005 Jul 1;115(4):528-38.


p53 in breast cancer subtypes and new insights into response to chemotherapy.

Bertheau P, Lehmann-Che J, Varna M, Dumay A, Poirot B, Porcher R, Turpin E, Plassa LF, de Roquancourt A, Bourstyn E, de Cremoux P, Janin A, Giacchetti S, Espié M, de Thé H.

Breast. 2013 Aug;22 Suppl 2:S27-9. doi: 10.1016/j.breast.2013.07.005. Review.


Fibroblast growth factor receptor inhibition synergizes with Paclitaxel and Doxorubicin in endometrial cancer cells.

Byron SA, Loch DC, Pollock PM.

Int J Gynecol Cancer. 2012 Nov;22(9):1517-26. doi: 10.1097/IGC.0b013e31826f6806.


Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.

Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN.

Mol Cancer Ther. 2015 Feb;14(2):608-19. doi: 10.1158/1535-7163.MCT-14-0735-T. Epub 2014 Dec 10.


Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Indovina P, Marcelli E, Di Marzo D, Casini N, Forte IM, Giorgi F, Alfano L, Pentimalli F, Giordano A.

Cancer Biol Ther. 2014 Apr;15(4):380-8. doi: 10.4161/cbt.27623. Epub 2014 Jan 14.


Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel KW, Leslie KK.

PLoS One. 2011;6(6):e20920. doi: 10.1371/journal.pone.0020920. Epub 2011 Jun 8.


Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.

Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN, Frederick MJ.

Mol Cancer Ther. 2013 Sep;12(9):1860-73. doi: 10.1158/1535-7163.MCT-13-0157. Epub 2013 Jul 9.


P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells.

Bajbouj K, Mawrin C, Hartig R, Schulze-Luehrmann J, Wilisch-Neumann A, Roessner A, Schneider-Stock R.

J Neurooncol. 2012 May;107(3):503-16. doi: 10.1007/s11060-011-0791-2. Epub 2012 Jan 20.


Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells.

Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH.

Food Chem Toxicol. 2011 Aug;49(8):1737-44. doi: 10.1016/j.fct.2011.04.019. Epub 2011 Apr 29.


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