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Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.

Bashour KT, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC.

Mol Cell Biol. 2014 Mar;34(6):955-64. doi: 10.1128/MCB.00842-13. Epub 2013 Dec 30.


TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity.

Govers C, Sebestyén Z, Roszik J, van Brakel M, Berrevoets C, Szöőr Á, Panoutsopoulou K, Broertjes M, Van T, Vereb G, Szöllősi J, Debets R.

J Immunol. 2014 Nov 15;193(10):5315-26. doi: 10.4049/jimmunol.1302074. Epub 2014 Oct 15.


CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.

Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9369-73. Epub 2002 Jun 20.


Differences in responsiveness to CD3 stimulation between naive and memory CD4+ T cells cannot be overcome by CD28 costimulation.

Kuiper H, Brouwer M, de Boer M, Parren P, van Lier RA.

Eur J Immunol. 1994 Sep;24(9):1956-60.


Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.

Semple K, Nguyen A, Yu Y, Wang H, Anasetti C, Yu XZ.

Blood. 2011 Mar 17;117(11):3096-103. doi: 10.1182/blood-2010-08-301275. Epub 2011 Jan 18.


Micropatterning of costimulatory ligands enhances CD4+ T cell function.

Shen K, Thomas VK, Dustin ML, Kam LC.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7791-6. doi: 10.1073/pnas.0710295105. Epub 2008 May 27.


TCR alpha beta-independent CD28 signaling and costimulation require non-CD4-associated Lck.

Leung BL, Haughn L, Veillette A, Hawley RG, Rottapel R, Julius M.

J Immunol. 1999 Aug 1;163(3):1334-41.


CD28 and CD3 have complementary roles in T-cell traction forces.

Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2241-6. doi: 10.1073/pnas.1315606111. Epub 2014 Jan 27.


Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling.

Smeets RL, Fleuren WW, He X, Vink PM, Wijnands F, Gorecka M, Klop H, Bauerschmidt S, Garritsen A, Koenen HJ, Joosten I, Boots AM, Alkema W.

BMC Immunol. 2012 Mar 14;13:12. doi: 10.1186/1471-2172-13-12.


Differential loss of T cell signaling molecules in metastatic melanoma patients' T lymphocyte subsets expressing distinct TCR variable regions.

Maccalli C, Pisarra P, Vegetti C, Sensi M, Parmiani G, Anichini A.

J Immunol. 1999 Dec 15;163(12):6912-23.


Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

Abe R, Vandenberghe P, Craighead N, Smoot DS, Lee KP, June CH.

J Immunol. 1995 Feb 1;154(3):985-97.


The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.

Gibson S, August A, Kawakami Y, Kawakami T, Dupont B, Mills GB.

J Immunol. 1996 Apr 15;156(8):2716-22.


IκB kinase β is required for activation of NF-κB and AP-1 in CD3/CD28-stimulated primary CD4(+) T cells.

Lupino E, Ramondetti C, Piccinini M.

J Immunol. 2012 Mar 15;188(6):2545-55. doi: 10.4049/jimmunol.1102938. Epub 2012 Feb 13.


CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells.

Kaminski DA, Lee BO, Eaton SM, Haynes L, Randall TD.

Immunology. 2009 Jul;127(3):373-85. doi: 10.1111/j.1365-2567.2008.02991.x. Epub 2008 Dec 13.


Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.

Janardhan SV, Praveen K, Marks R, Gajewski TF.

PLoS One. 2011;6(9):e24931. doi: 10.1371/journal.pone.0024931. Epub 2011 Sep 19.


Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.

Sugie K, Jeon MS, Grey HM.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14859-64. Epub 2004 Oct 1.


Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals.

Meyaard L, Kuiper H, Otto SA, Wolthers KC, van Lier RA, Miedema F.

Eur J Immunol. 1995 Jan;25(1):232-7.


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