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Items: 1 to 20 of 55

1.

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.

Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):829-32. doi: 10.1073/pnas.1314085111. Epub 2013 Dec 30.

2.

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.

3.

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S.

Neuron. 2014 Mar 5;81(5):1001-8. doi: 10.1016/j.neuron.2014.01.011. Epub 2014 Feb 6.

4.

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.

5.

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis.

Cassina P, Peluffo H, Pehar M, Martinez-Palma L, Ressia A, Beckman JS, Estévez AG, Barbeito L.

J Neurosci Res. 2002 Jan 1;67(1):21-9.

PMID:
11754077
6.

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.

Burkhardt MF, Martinez FJ, Wright S, Ramos C, Volfson D, Mason M, Garnes J, Dang V, Lievers J, Shoukat-Mumtaz U, Martinez R, Gai H, Blake R, Vaisberg E, Grskovic M, Johnson C, Irion S, Bright J, Cooper B, Nguyen L, Griswold-Prenner I, Javaherian A.

Mol Cell Neurosci. 2013 Sep;56:355-64. doi: 10.1016/j.mcn.2013.07.007. Epub 2013 Jul 25.

7.

ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

Hedlund E, Isacson O.

Cell Stem Cell. 2008 Dec 4;3(6):575-6. doi: 10.1016/j.stem.2008.11.004. Review.

8.

Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis.

Pehar M, Vargas MR, Cassina P, Barbeito AG, Beckman JS, Barbeito L.

Neurodegener Dis. 2005;2(3-4):139-46. Review.

PMID:
16909019
9.

Motor neuron-astrocyte interactions and levels of Cu,Zn superoxide dismutase in sporadic amyotrophic lateral sclerosis.

O'Reilly SA, Roedica J, Nagy D, Hallewell RA, Alderson K, Marklund SL, Kuby J, Kushner PD.

Exp Neurol. 1995 Feb;131(2):203-10.

PMID:
7895821
10.

Motor neuron death in ALS: programmed by astrocytes?

Pirooznia SK, Dawson VL, Dawson TM.

Neuron. 2014 Mar 5;81(5):961-3. doi: 10.1016/j.neuron.2014.02.024.

11.

The non-cell-autonomous component of ALS: new in vitro models and future challenges.

Ferraiuolo L.

Biochem Soc Trans. 2014 Oct;42(5):1270-4. doi: 10.1042/BST20140168.

PMID:
25233402
12.

Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS.

Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P.

Integr Biol (Camb). 2013 Jul 24;5(7):964-75. doi: 10.1039/c3ib40022k. Epub 2013 May 22.

PMID:
23695230
13.

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.

Qian K, Huang H, Peterson A, Hu B, Maragakis NJ, Ming GL, Chen H, Zhang SC.

Stem Cell Reports. 2017 Apr 11;8(4):843-855. doi: 10.1016/j.stemcr.2017.03.003. Epub 2017 Mar 30.

14.

Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis.

Thonhoff JR, Ojeda L, Wu P.

Curr Stem Cell Res Ther. 2009 Sep;4(3):178-99. Review.

15.

New In Vitro Models to Study Amyotrophic Lateral Sclerosis.

Myszczynska M, Ferraiuolo L.

Brain Pathol. 2016 Mar;26(2):258-65. doi: 10.1111/bpa.12353. Review.

PMID:
26780562
16.

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC.

Cell Stem Cell. 2008 Dec 4;3(6):637-48. doi: 10.1016/j.stem.2008.09.017.

17.

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Song S, Miranda CJ, Braun L, Meyer K, Frakes AE, Ferraiuolo L, Likhite S, Bevan AK, Foust KD, McConnell MJ, Walker CM, Kaspar BK.

Nat Med. 2016 Apr;22(4):397-403. doi: 10.1038/nm.4052. Epub 2016 Feb 29.

18.

Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms.

Wächter N, Storch A, Hermann A.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):431-41. doi: 10.3109/21678421.2015.1055275. Epub 2015 Sep 7.

PMID:
26174443
19.

Altered astrocytic expression of TDP-43 does not influence motor neuron survival.

Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ.

Exp Neurol. 2013 Dec;250:250-9. doi: 10.1016/j.expneurol.2013.10.004. Epub 2013 Oct 9.

PMID:
24120466
20.

Induced differentiation of neural stem cells of astrocytic origin to motor neurons in the rat.

Shao Z, Luo Q, Liu D, Mi Y, Zhang P, Ju G.

Stem Cells Dev. 2011 Jul;20(7):1163-70. doi: 10.1089/scd.2010.0262. Epub 2011 Jan 16.

PMID:
21087155

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