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Items: 1 to 20 of 147

1.

Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.

González-Naranjo P, Pérez-Macias N, Campillo NE, Pérez C, Arán VJ, Girón R, Sánchez-Robles E, Martín MI, Gómez-Cañas M, García-Arencibia M, Fernández-Ruiz J, Páez JA.

Eur J Med Chem. 2014 Feb 12;73:56-72. doi: 10.1016/j.ejmech.2013.11.026. Epub 2013 Dec 7.

PMID:
24378710
2.

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists.

Yrjölä S, Sarparanta M, Airaksinen AJ, Hytti M, Kauppinen A, Pasonen-Seppänen S, Adinolfi B, Nieri P, Manera C, Keinänen O, Poso A, Nevalainen TJ, Parkkari T.

Eur J Pharm Sci. 2015 Jan 25;67:85-96. doi: 10.1016/j.ejps.2014.11.003. Epub 2014 Nov 14.

PMID:
25447744
3.

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA.

Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Glass M, Connor M, McGregor IS, Kassiou M.

ACS Chem Neurosci. 2015 Sep 16;6(9):1546-59. doi: 10.1021/acschemneuro.5b00112. Epub 2015 Jul 17.

PMID:
26134475
4.

Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.

Li Y, Peng P, Tang L, Hu Y, Hu Y, Sheng R.

Bioorg Med Chem. 2014 Sep 1;22(17):4717-25. doi: 10.1016/j.bmc.2014.07.009. Epub 2014 Jul 12.

PMID:
25082512
5.

Multitarget cannabinoids as novel strategy for Alzheimer disease.

González-Naranjo P, Campillo NE, Pérez C, Páez JA.

Curr Alzheimer Res. 2013 Mar;10(3):229-39.

PMID:
23369066
6.

Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase.

Wang DM, Feng B, Fu H, Liu AL, Wang L, Du GH, Wu S.

Molecules. 2017 Jan 20;22(1). pii: E172. doi: 10.3390/molecules22010172.

7.

Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands.

Davis MP.

Expert Opin Investig Drugs. 2014 Aug;23(8):1123-40. doi: 10.1517/13543784.2014.918603. Epub 2014 May 16. Review.

PMID:
24836296
8.

Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling.

Feng B, Li X, Xia J, Wu S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):968-977. doi: 10.1080/14756366.2017.1347163.

PMID:
28718678
9.

Synthesis of some new 3-coumaranone and coumarin derivatives as dual inhibitors of acetyl- and butyrylcholinesterase.

Alipour M, Khoobi M, Nadri H, Sakhteman A, Moradi A, Ghandi M, Foroumadi A, Shafiee A.

Arch Pharm (Weinheim). 2013 Aug;346(8):577-87. doi: 10.1002/ardp.201300080. Epub 2013 Jul 15.

PMID:
23852709
10.

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.

J Med Chem. 2011 Dec 22;54(24):8251-70. doi: 10.1021/jm200853t. Epub 2011 Nov 15.

PMID:
22023459
11.

Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.

Skrzypek A, Matysiak J, Niewiadomy A, Bajda M, Szymański P.

Eur J Med Chem. 2013 Apr;62:311-9. doi: 10.1016/j.ejmech.2012.12.060. Epub 2013 Jan 11.

PMID:
23376249
12.

Design, synthesis and biological activity of 1H-indene-2-carboxamides as multi-targeted anti-Alzheimer agents.

Koca M, Yerdelen KO, Anil B, Kasap Z, Sevindik H, Ozyurek I, Gunesacar G, Turkaydin K.

J Enzyme Inhib Med Chem. 2016;31(sup2):13-23. Epub 2016 May 26.

PMID:
27226239
13.

Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.

Huang G, Pemp D, Stadtmüller P, Nimczick M, Heilmann J, Decker M.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4209-14. doi: 10.1016/j.bmcl.2014.07.038. Epub 2014 Jul 19.

PMID:
25096297
14.

Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders.

Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmüller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M.

ChemMedChem. 2016 Jun 20;11(12):1270-83. doi: 10.1002/cmdc.201500418. Epub 2015 Nov 9.

PMID:
26548365
15.

Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.

Shaik JB, Palaka BK, Penumala M, Eadlapalli S, Darla Mark M, Ampasala DR, Vadde R, Amooru Gangaiah D.

Chem Biol Drug Des. 2016 Jul;88(1):43-53. doi: 10.1111/cbdd.12732. Epub 2016 Feb 24.

PMID:
26833890
16.

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.

Huang L, Miao H, Sun Y, Meng F, Li X.

Eur J Med Chem. 2014 Nov 24;87:429-39. doi: 10.1016/j.ejmech.2014.09.081. Epub 2014 Sep 26.

PMID:
25282266
17.

Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.

Kanhed AM, Sinha A, Machhi J, Tripathi A, Parikh ZS, Pillai PP, Giridhar R, Yadav MR.

Bioorg Chem. 2015 Aug;61:7-12. doi: 10.1016/j.bioorg.2015.05.005. Epub 2015 May 21.

PMID:
26042530
18.

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.

Eur J Med Chem. 2012 Jun;52:251-62. doi: 10.1016/j.ejmech.2012.03.022. Epub 2012 Mar 30.

PMID:
22503231
19.

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.

Li Z, Wang B, Hou JQ, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.

J Enzyme Inhib Med Chem. 2013 Jun;28(3):583-92. doi: 10.3109/14756366.2012.663363. Epub 2012 Mar 1.

PMID:
22380775
20.

Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1.

Espinosa-Bustos C, Lagos CF, Romero-Parra J, Zárate AM, Mella-Raipán J, Pessoa-Mahana H, Recabarren-Gajardo G, Iturriaga-Vásquez P, Tapia RA, Pessoa-Mahana CD.

Arch Pharm (Weinheim). 2015 Feb;348(2):81-8. doi: 10.1002/ardp.201400201. Epub 2015 Jan 13.

PMID:
25641513

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