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Items: 1 to 20 of 112

1.

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH.

Cell Metab. 2014 Jan 7;19(1):135-45. doi: 10.1016/j.cmet.2013.11.016. Epub 2013 Dec 26.

2.

Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone.

Lehner B, Kunz P, Saehr H, Fellenberg J.

BMC Cancer. 2014 Jul 9;14:495. doi: 10.1186/1471-2407-14-495.

3.

Silencing of the imprinted DLK1-MEG3 locus in human clinically nonfunctioning pituitary adenomas.

Cheunsuchon P, Zhou Y, Zhang X, Lee H, Chen W, Nakayama Y, Rice KA, Tessa Hedley-Whyte E, Swearingen B, Klibanski A.

Am J Pathol. 2011 Oct;179(4):2120-30. doi: 10.1016/j.ajpath.2011.07.002. Epub 2011 Aug 24.

4.

Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations.

Kagami M, Matsuoka K, Nagai T, Yamanaka M, Kurosawa K, Suzumori N, Sekita Y, Miyado M, Matsubara K, Fuke T, Kato F, Fukami M, Ogata T.

Epigenetics. 2012 Oct;7(10):1142-50. doi: 10.4161/epi.21937. Epub 2012 Aug 23.

5.

Abnormal DLK1/MEG3 imprinting correlates with decreased HERV-K methylation after assisted reproduction and preimplantation genetic diagnosis.

Dimitriadou E, Noutsopoulos D, Markopoulos G, Vlaikou AM, Mantziou S, Traeger-Synodinos J, Kanavakis E, Chrousos GP, Tzavaras T, Syrrou M.

Stress. 2013 Nov;16(6):689-97. doi: 10.3109/10253890.2013.817554. Epub 2013 Jul 25.

PMID:
23786541
6.

At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.

Hagan JP, O'Neill BL, Stewart CL, Kozlov SV, Croce CM.

PLoS One. 2009;4(2):e4352. doi: 10.1371/journal.pone.0004352. Epub 2009 Feb 5.

7.

Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region.

Kircher M, Bock C, Paulsen M.

BMC Genomics. 2008 Jul 23;9:346. doi: 10.1186/1471-2164-9-346.

8.

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C.

PLoS Genet. 2014 Mar 6;10(3):e1004160. doi: 10.1371/journal.pgen.1004160. eCollection 2014 Mar.

9.

Temple syndrome as a result of isolated hypomethylation of the 14q32 imprinted DLK1/MEG3 region.

Briggs TA, Lokulo-Sodipe K, Chandler KE, Mackay DJ, Temple IK.

Am J Med Genet A. 2016 Jan;170A(1):170-5. doi: 10.1002/ajmg.a.37400. Epub 2015 Sep 23.

PMID:
26395259
10.

Epimutations of the IG-DMR and the MEG3-DMR at the 14q32.2 imprinted region in two patients with Silver-Russell Syndrome-compatible phenotype.

Kagami M, Mizuno S, Matsubara K, Nakabayashi K, Sano S, Fuke T, Fukami M, Ogata T.

Eur J Hum Genet. 2015 Aug;23(8):1062-7. doi: 10.1038/ejhg.2014.234. Epub 2014 Nov 5.

11.

DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.

Luk JM, Burchard J, Zhang C, Liu AM, Wong KF, Shek FH, Lee NP, Fan ST, Poon RT, Ivanovska I, Philippar U, Cleary MA, Buser CA, Shaw PM, Lee CN, Tenen DG, Dai H, Mao M.

J Biol Chem. 2011 Sep 2;286(35):30706-13. doi: 10.1074/jbc.M111.229831. Epub 2011 Jul 7.

12.

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.

van de Bunt M, Gaulton KJ, Parts L, Moran I, Johnson PR, Lindgren CM, Ferrer J, Gloyn AL, McCarthy MI.

PLoS One. 2013;8(1):e55272. doi: 10.1371/journal.pone.0055272. Epub 2013 Jan 25.

13.

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion.

Sebastiani G, Po A, Miele E, Ventriglia G, Ceccarelli E, Bugliani M, Marselli L, Marchetti P, Gulino A, Ferretti E, Dotta F.

Acta Diabetol. 2015 Jun;52(3):523-30. doi: 10.1007/s00592-014-0675-y. Epub 2014 Nov 19.

PMID:
25408296
14.

Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors.

Modali SD, Parekh VI, Kebebew E, Agarwal SK.

Mol Endocrinol. 2015 Feb;29(2):224-37. doi: 10.1210/me.2014-1304. Epub 2015 Jan 7.

15.

Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells.

You L, Wang N, Yin D, Wang L, Jin F, Zhu Y, Yuan Q, De W.

J Cell Physiol. 2016 Apr;231(4):852-62. doi: 10.1002/jcp.25175. Epub 2015 Sep 9.

PMID:
26313443
16.

A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain.

Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaillé J.

Genome Res. 2004 Sep;14(9):1741-8. Epub 2004 Aug 12.

17.

Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas.

Gejman R, Batista DL, Zhong Y, Zhou Y, Zhang X, Swearingen B, Stratakis CA, Hedley-Whyte ET, Klibanski A.

J Clin Endocrinol Metab. 2008 Oct;93(10):4119-25. doi: 10.1210/jc.2007-2633. Epub 2008 Jul 15.

18.

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.

Volkov P, Bacos K, Ofori JK, Esguerra JL, Eliasson L, Rönn T, Ling C.

Diabetes. 2017 Apr;66(4):1074-1085. doi: 10.2337/db16-0996. Epub 2017 Jan 4.

PMID:
28052964
19.

The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis.

Benetatos L, Hatzimichael E, Londin E, Vartholomatos G, Loher P, Rigoutsos I, Briasoulis E.

Cell Mol Life Sci. 2013 Mar;70(5):795-814. doi: 10.1007/s00018-012-1080-8. Epub 2012 Jul 24. Review.

PMID:
22825660
20.

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.

Wallace C, Smyth DJ, Maisuria-Armer M, Walker NM, Todd JA, Clayton DG.

Nat Genet. 2010 Jan;42(1):68-71. doi: 10.1038/ng.493. Epub 2009 Dec 6.

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