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Items: 1 to 20 of 110

1.

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA.

Stem Cell Reports. 2013 Dec 17;1(6):518-31. doi: 10.1016/j.stemcr.2013.11.010. eCollection 2013.

2.

PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.

Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y.

Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11.

3.

FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W.

Cell Stem Cell. 2013 Sep 5;13(3):351-9. doi: 10.1016/j.stem.2013.06.004. Epub 2013 Jul 11.

4.

Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.

Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP.

Mol Cell Biol. 2015 Mar;35(6):1026-42. doi: 10.1128/MCB.01172-14. Epub 2015 Jan 12.

5.

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W.

Nature. 2011 May 19;473(7347):398-402. doi: 10.1038/nature10008. Epub 2011 Apr 3.

PMID:
21460836
6.

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.

Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S.

Genome Biol. 2013 Aug 29;14(8):R91. doi: 10.1186/gb-2013-14-8-r91.

7.

DAZL regulates Tet1 translation in murine embryonic stem cells.

Welling M, Chen HH, Muñoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N.

EMBO Rep. 2015 Jul;16(7):791-802. doi: 10.15252/embr.201540538. Epub 2015 Jun 15.

8.

PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.

Okashita N, Sakashita N, Ito K, Mitsuya A, Suwa Y, Seki Y.

Biochem Biophys Res Commun. 2015 Oct 9;466(1):138-45. doi: 10.1016/j.bbrc.2015.08.122. Epub 2015 Aug 29.

PMID:
26325469
9.

Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A, Santos F, Petrini E, Milagre I, Yu M, Xie Z, Kroeze LI, Nesterova TB, Jansen JH, Xie H, He C, Reik W, Stunnenberg HG.

Mol Cell. 2016 Jun 16;62(6):848-861. doi: 10.1016/j.molcel.2016.04.025. Epub 2016 May 26. Erratum in: Mol Cell. 2016 Jun 16;62(6):983.

10.

Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.

Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT.

Cell Stem Cell. 2013 Apr 4;12(4):470-8. doi: 10.1016/j.stem.2013.01.016. Epub 2013 Feb 14.

11.

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.

Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y.

Stem Cell Reports. 2016 Dec 13;7(6):1072-1086. doi: 10.1016/j.stemcr.2016.10.007. Epub 2016 Nov 17.

12.

Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.

Habibi E, Brinkman AB, Arand J, Kroeze LI, Kerstens HH, Matarese F, Lepikhov K, Gut M, Brun-Heath I, Hubner NC, Benedetti R, Altucci L, Jansen JH, Walter J, Gut IG, Marks H, Stunnenberg HG.

Cell Stem Cell. 2013 Sep 5;13(3):360-9. doi: 10.1016/j.stem.2013.06.002. Epub 2013 Jul 11.

13.

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D.

Stem Cells. 2017 Mar;35(3):611-625. doi: 10.1002/stem.2521. Epub 2016 Nov 8.

14.

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.

Dawlaty MM, Breiling A, Le T, Raddatz G, Barrasa MI, Cheng AW, Gao Q, Powell BE, Li Z, Xu M, Faull KF, Lyko F, Jaenisch R.

Dev Cell. 2013 Feb 11;24(3):310-23. doi: 10.1016/j.devcel.2012.12.015. Epub 2013 Jan 24.

15.

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.

Dawlaty MM, Ganz K, Powell BE, Hu YC, Markoulaki S, Cheng AW, Gao Q, Kim J, Choi SW, Page DC, Jaenisch R.

Cell Stem Cell. 2011 Aug 5;9(2):166-75. doi: 10.1016/j.stem.2011.07.010.

16.

Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition.

Acampora D, Di Giovannantonio LG, Simeone A.

Development. 2013 Jan 1;140(1):43-55. doi: 10.1242/dev.085290. Epub 2012 Nov 15.

17.

Naive pluripotency is associated with global DNA hypomethylation.

Leitch HG, McEwen KR, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA, Hajkova P.

Nat Struct Mol Biol. 2013 Mar;20(3):311-6. doi: 10.1038/nsmb.2510. Epub 2013 Feb 17.

18.

Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells.

Wu H, Zhang Y.

Cell Cycle. 2011 Aug 1;10(15):2428-36. Epub 2011 Aug 1.

19.

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M.

Nature. 2013 Aug 8;500(7461):222-6. doi: 10.1038/nature12362. Epub 2013 Jun 30.

20.

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.

Huang Y, Chavez L, Chang X, Wang X, Pastor WA, Kang J, Zepeda-Martínez JA, Pape UJ, Jacobsen SE, Peters B, Rao A.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1361-6. doi: 10.1073/pnas.1322921111. Epub 2014 Jan 13.

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