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Items: 1 to 20 of 96

1.

Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.

Jochmann K, Bachvarova V, Vortkamp A.

Matrix Biol. 2014 Feb;34:55-63. doi: 10.1016/j.matbio.2013.11.003. Epub 2013 Dec 24. Review.

2.

Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.

Jochmann K, Bachvarova V, Vortkamp A.

Matrix Biol. 2014 Apr;35:239-47. doi: 10.1016/j.matbio.2014.04.001. Epub 2014 Apr 12.

3.

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

Koziel L, Kunath M, Kelly OG, Vortkamp A.

Dev Cell. 2004 Jun;6(6):801-13.

4.

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development.

Hilton MJ, Gutiérrez L, Martinez DA, Wells DE.

Bone. 2005 Mar;36(3):379-86.

PMID:
15777636
5.

Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes.

Hecht JT, Hayes E, Haynes R, Cole WG, Long RJ, Farach-Carson MC, Carson DD.

Differentiation. 2005 Jun;73(5):212-21.

PMID:
16026543
6.

Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice.

Morimoto K, Shimizu T, Furukawa K, Morio H, Kurosawa H, Shirasawa T.

Biochem Biophys Res Commun. 2002 Apr 12;292(4):999-1009.

PMID:
11944914
7.

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.

Sinha S, Mundy C, Bechtold T, Sgariglia F, Ibrahim MM, Billings PC, Carroll K, Koyama E, Jones KB, Pacifici M.

PLoS Genet. 2017 Apr 26;13(4):e1006742. doi: 10.1371/journal.pgen.1006742. eCollection 2017 Apr.

8.
9.

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.

Dierker T, Bachvarova V, Krause Y, Li JP, Kjellén L, Seidler DG, Vortkamp A.

Matrix Biol. 2016 Jan;49:82-92. doi: 10.1016/j.matbio.2015.06.004. Epub 2015 Jun 24.

PMID:
26116392
10.

Interaction of growth factors regulating chondrocyte differentiation in the developing embryo.

Vortkamp A.

Osteoarthritis Cartilage. 2001;9 Suppl A:S109-17. Review.

PMID:
11680674
11.

Chondrocyte proliferation and differentiation.

Wuelling M, Vortkamp A.

Endocr Dev. 2011;21:1-11. doi: 10.1159/000328081. Epub 2011 Aug 22. Review.

PMID:
21865749
12.

Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.

Sgariglia F, Candela ME, Huegel J, Jacenko O, Koyama E, Yamaguchi Y, Pacifici M, Enomoto-Iwamoto M.

Bone. 2013 Nov;57(1):220-31. doi: 10.1016/j.bone.2013.08.012. Epub 2013 Aug 17.

13.

Cell biology of osteochondromas: bone morphogenic protein signalling and heparan sulphates.

Cuellar A, Reddi AH.

Int Orthop. 2013 Aug;37(8):1591-6. doi: 10.1007/s00264-013-1906-5. Epub 2013 Jun 15. Review.

14.

Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses.

Huegel J, Sgariglia F, Enomoto-Iwamoto M, Koyama E, Dormans JP, Pacifici M.

Dev Dyn. 2013 Sep;242(9):1021-32. doi: 10.1002/dvdy.24010. Epub 2013 Jul 29. Review.

15.

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.

Busse M, Feta A, Presto J, Wilén M, Grønning M, Kjellén L, Kusche-Gullberg M.

J Biol Chem. 2007 Nov 9;282(45):32802-10. Epub 2007 Aug 29.

16.
17.

No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas.

Reijnders CM, Waaijer CJ, Hamilton A, Buddingh EP, Dijkstra SP, Ham J, Bakker E, Szuhai K, Karperien M, Hogendoorn PC, Stringer SE, Bovée JV.

Am J Pathol. 2010 Oct;177(4):1946-57. doi: 10.2353/ajpath.2010.100296. Epub 2010 Sep 2.

18.

Indian hedgehog signaling promotes chondrocyte differentiation in enchondral ossification in human cervical ossification of the posterior longitudinal ligament.

Sugita D, Yayama T, Uchida K, Kokubo Y, Nakajima H, Yamagishi A, Takeura N, Baba H.

Spine (Phila Pa 1976). 2013 Oct 15;38(22):E1388-96. doi: 10.1097/BRS.0b013e3182a40489.

PMID:
23883825
19.

Heparan sulfate abnormalities in exostosis growth plates.

Hecht JT, Hall CR, Snuggs M, Hayes E, Haynes R, Cole WG.

Bone. 2002 Jul;31(1):199-204.

PMID:
12110435
20.

A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.

Matsumoto K, Irie F, Mackem S, Yamaguchi Y.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10932-7. doi: 10.1073/pnas.0914642107. Epub 2010 Jun 1.

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