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Items: 1 to 20 of 134

1.

Comparative structural and conformational studies on H43R and W32F mutants of copper-zinc superoxide dismutase by molecular dynamics simulation.

Muneeswaran G, Kartheeswaran S, Muthukumar K, Dharmaraj CD, Karunakaran C.

Biophys Chem. 2014 Jan;185:70-8. doi: 10.1016/j.bpc.2013.11.010. Epub 2013 Dec 11.

PMID:
24369116
2.

Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase.

Strange RW, Yong CW, Smith W, Hasnain SS.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10040-4. Epub 2007 Jun 4.

3.

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.

DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA.

J Mol Biol. 2003 Sep 19;332(3):601-15. Erratum in: J Mol Biol. 2003 Nov 14;334(1):175.

PMID:
12963370
4.

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.

Schmidlin T, Kennedy BK, Daggett V.

Biophys J. 2009 Sep 16;97(6):1709-18. doi: 10.1016/j.bpj.2009.06.043.

5.

The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.

Chattopadhyay M, Nwadibia E, Strong CD, Gralla EB, Valentine JS, Whitelegge JP.

J Biol Chem. 2015 Dec 18;290(51):30624-36. doi: 10.1074/jbc.M115.666503. Epub 2015 Oct 28.

6.
7.

Structural instability and Cu-dependent pro-oxidant activity acquired by the apo form of mutant SOD1 associated with amyotrophic lateral sclerosis.

Kitamura F, Fujimaki N, Okita W, Hiramatsu H, Takeuchi H.

Biochemistry. 2011 May 24;50(20):4242-50. doi: 10.1021/bi200338h. Epub 2011 May 2.

PMID:
21506602
8.

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.

Molnar KS, Karabacak NM, Johnson JL, Wang Q, Tiwari A, Hayward LJ, Coales SJ, Hamuro Y, Agar JN.

J Biol Chem. 2009 Nov 6;284(45):30965-73. doi: 10.1074/jbc.M109.023945. Epub 2009 Jul 27.

9.

Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study.

Milardi D, Pappalardo M, Grasso DM, La Rosa C.

Mol Biosyst. 2010 Jun;6(6):1032-9. doi: 10.1039/b918662j. Epub 2010 Feb 23.

PMID:
20485746
10.

Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.

Mulligan VK, Kerman A, Ho S, Chakrabartty A.

J Mol Biol. 2008 Nov 7;383(2):424-36. doi: 10.1016/j.jmb.2008.08.024. Epub 2008 Aug 22.

PMID:
18761352
11.

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.

Ray SS, Nowak RJ, Brown RH Jr, Lansbury PT Jr.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3639-44. Epub 2005 Feb 28.

12.

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

Antonyuk S, Elam JS, Hough MA, Strange RW, Doucette PA, Rodriguez JA, Hayward LJ, Valentine JS, Hart PJ, Hasnain SS.

Protein Sci. 2005 May;14(5):1201-13.

13.

Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis.

Valentine JS, Doucette PA, Zittin Potter S.

Annu Rev Biochem. 2005;74:563-93. Review.

PMID:
15952898
14.

SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization.

Banci L, Bertini I, Boca M, Girotto S, Martinelli M, Valentine JS, Vieru M.

PLoS One. 2008 Feb 27;3(2):e1677. doi: 10.1371/journal.pone.0001677.

15.

An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.

Ray SS, Nowak RJ, Strokovich K, Brown RH Jr, Walz T, Lansbury PT Jr.

Biochemistry. 2004 May 4;43(17):4899-905.

PMID:
15109247
16.

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations.

Lim L, Lee X, Song J.

Biochim Biophys Acta. 2015 Jan;1848(1 Pt A):1-7. doi: 10.1016/j.bbamem.2014.10.002. Epub 2014 Oct 12.

17.

Dimerization, oligomerization, and aggregation of human amyotrophic lateral sclerosis copper/zinc superoxide dismutase 1 protein mutant forms in live cells.

Kim J, Lee H, Lee JH, Kwon DY, Genovesio A, Fenistein D, Ogier A, Brondani V, Grailhe R.

J Biol Chem. 2014 May 23;289(21):15094-103. doi: 10.1074/jbc.M113.542613. Epub 2014 Apr 1.

19.
20.

Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation.

Ding F, Dokholyan NV.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19696-701. doi: 10.1073/pnas.0803266105. Epub 2008 Dec 3.

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