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Items: 1 to 20 of 191

1.

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E15-24. doi: 10.1073/pnas.1318503111. Epub 2013 Dec 23.

2.

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.

Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, Benkirane M.

Mol Cell. 2010 May 14;38(3):439-51. doi: 10.1016/j.molcel.2010.04.012.

3.

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4.

Gu J, Babayeva ND, Suwa Y, Baranovskiy AG, Price DH, Tahirov TH.

Cell Cycle. 2014;13(11):1788-97. doi: 10.4161/cc.28756. Epub 2014 Apr 11.

4.

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10.

5.

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.

PLoS Pathog. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338. Epub 2013 May 2.

6.

The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.

Krueger BJ, Varzavand K, Cooper JJ, Price DH.

PLoS One. 2010 Aug 23;5(8):e12335. doi: 10.1371/journal.pone.0012335.

7.

CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA.

Mol Cell Biol. 2000 Sep;20(18):6958-69.

8.

A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.

Kuzmina A, Verstraete N, Galker S, Maatook M, Bensaude O, Taube R.

Retrovirology. 2014 Jul 1;11:51. doi: 10.1186/1742-4690-11-51.

9.

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

Barboric M, Yik JH, Czudnochowski N, Yang Z, Chen R, Contreras X, Geyer M, Matija Peterlin B, Zhou Q.

Nucleic Acids Res. 2007;35(6):2003-12. Epub 2007 Mar 6.

10.

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.

Lu H, Li Z, Zhang W, Schulze-Gahmen U, Xue Y, Zhou Q.

Nucleic Acids Res. 2015 Jul 13;43(12):5868-79. doi: 10.1093/nar/gkv541. Epub 2015 May 24.

11.

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.

Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O.

Mol Cell Biol. 2003 Jul;23(14):4859-69. Erratum in: Mol Cell Biol. 2003 Dec;23(24):9405.

12.

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.

Schulze-Gahmen U, Upton H, Birnberg A, Bao K, Chou S, Krogan NJ, Zhou Q, Alber T.

Elife. 2013 Mar 5;2:e00327. doi: 10.7554/eLife.00327.

13.

Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Epub 2012 Sep 5. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.

14.

Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.

Cho WK, Jang MK, Huang K, Pise-Masison CA, Brady JN.

J Virol. 2010 Dec;84(24):12801-9. doi: 10.1128/JVI.00943-10. Epub 2010 Oct 6.

16.

Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.

McNamara RP, McCann JL, Gudipaty SA, D'Orso I.

Cell Rep. 2013 Dec 12;5(5):1256-68. doi: 10.1016/j.celrep.2013.11.003. Epub 2013 Dec 5.

17.

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855. Epub 2011 Nov 14.

18.

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription.

Yang Z, Zhu Q, Luo K, Zhou Q.

Nature. 2001 Nov 15;414(6861):317-22.

PMID:
11713532
19.

New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).

He N, Zhou Q.

J Neuroimmune Pharmacol. 2011 Jun;6(2):260-8. doi: 10.1007/s11481-011-9267-6. Epub 2011 Mar 1. Review.

20.

Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Muniz L, Egloff S, Ughy B, Jády BE, Kiss T.

PLoS Pathog. 2010 Oct 14;6(10):e1001152. doi: 10.1371/journal.ppat.1001152.

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