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Items: 1 to 20 of 230

1.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

Tu Y, Ji C, Yang B, Yang Z, Gu H, Lu CC, Wang R, Su ZL, Chen B, Sun WL, Xia JP, Bi ZG, He L.

Mol Cancer. 2013 Dec 24;12(1):172. doi: 10.1186/1476-4598-12-172.

2.

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.

Li Y, Wang X, Yue P, Tao H, Ramalingam SS, Owonikoko TK, Deng X, Wang Y, Fu H, Khuri FR, Sun SY.

J Biol Chem. 2013 May 10;288(19):13215-24. doi: 10.1074/jbc.M113.463679. Epub 2013 Mar 27.

3.

DNA-PKcs-SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation.

Xu Y, Fang SJ, Zhu LJ, Zhu LQ, Zhou XZ.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):362-7. doi: 10.1016/j.bbrc.2014.09.088. Epub 2014 Sep 27.

PMID:
25264192
4.

Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.

Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R.

J Biol Chem. 2005 May 27;280(21):20375-83. Epub 2005 Mar 25.

5.

DNA-PKcs is important for Akt activation and gemcitabine resistance in PANC-1 pancreatic cancer cells.

Hu H, Gu Y, Qian Y, Hu B, Zhu C, Wang G, Li J.

Biochem Biophys Res Commun. 2014 Sep 12;452(1):106-11. doi: 10.1016/j.bbrc.2014.08.059. Epub 2014 Aug 21.

PMID:
25152407
6.

DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600.

Wu L, Zhang J, Wu H, Han E.

Biochem Biophys Res Commun. 2015 Oct 23;466(3):547-53. doi: 10.1016/j.bbrc.2015.09.068. Epub 2015 Sep 14.

PMID:
26381179
8.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

9.

2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities.

Florczak U, Toulany M, Kehlbach R, Peter Rodemann H.

Radiother Oncol. 2009 Sep;92(3):334-8. doi: 10.1016/j.radonc.2009.06.005. Epub 2009 Jul 7.

PMID:
19589609
10.

Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo.

Wan YS, Wang ZQ, Shao Y, Voorhees JJ, Fisher GJ.

Int J Oncol. 2001 Mar;18(3):461-6.

PMID:
11179472
12.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

13.
14.

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP.

Mol Cancer Ther. 2008 Jul;7(7):1772-81. doi: 10.1158/1535-7163.MCT-07-2200.

15.

Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair.

Han W, Ming M, He YY.

J Biol Chem. 2011 Jul 1;286(26):22825-32. doi: 10.1074/jbc.M111.222349. Epub 2011 May 11.

16.

Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes.

Syed DN, Afaq F, Mukhtar H.

Photochem Photobiol. 2012 Sep-Oct;88(5):1184-90. doi: 10.1111/j.1751-1097.2012.01115.x. Epub 2012 Mar 19.

17.

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.

Nomura M, Kaji A, Ma WY, Zhong S, Liu G, Bowden GT, Miyamoto KI, Dong Z.

J Biol Chem. 2001 Jul 6;276(27):25558-67. Epub 2001 May 11.

18.

K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.

Minjgee M, Toulany M, Kehlbach R, Giehl K, Rodemann HP.

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1506-14. doi: 10.1016/j.ijrobp.2011.05.057. Epub 2011 Oct 8.

PMID:
21985943
19.

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.

Yang G, Murashige DS, Humphrey SJ, James DE.

Cell Rep. 2015 Aug 11;12(6):937-43. doi: 10.1016/j.celrep.2015.07.016. Epub 2015 Jul 30.

20.

Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.

Javvadi P, Makino H, Das AK, Lin YF, Chen DJ, Chen BP, Nirodi CS.

Mol Cancer Res. 2012 Oct;10(10):1359-68. doi: 10.1158/1541-7786.MCR-12-0482-T. Epub 2012 Aug 23.

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