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Items: 1 to 20 of 104

1.

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.

Luu W, Zerenturk EJ, Kristiana I, Bucknall MP, Sharpe LJ, Brown AJ.

J Lipid Res. 2014 Mar;55(3):410-20. doi: 10.1194/jlr.M043257. Epub 2013 Dec 20.

2.

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1).

Zerenturk EJ, Kristiana I, Gill S, Brown AJ.

Biochim Biophys Acta. 2012 Sep;1821(9):1269-77. doi: 10.1016/j.bbalip.2011.11.009. Epub 2011 Dec 10.

PMID:
22178193
3.

Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

Zerenturk EJ, Sharpe LJ, Ikonen E, Brown AJ.

Prog Lipid Res. 2013 Oct;52(4):666-80. doi: 10.1016/j.plipres.2013.09.002. Epub 2013 Oct 2. Review.

PMID:
24095826
4.

Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.

Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ.

Am J Hum Genet. 2001 Oct;69(4):685-94. Epub 2001 Aug 22.

5.

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally.

Luu W, Hart-Smith G, Sharpe LJ, Brown AJ.

J Lipid Res. 2015 Apr;56(4):888-97. doi: 10.1194/jlr.M056986. Epub 2015 Jan 31. Erratum in: J Lipid Res. 2015 May;56(5):1079.

6.

Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.

Tint GS, Pan L, Shang Q, Sharpe LJ, Brown AJ, Li M, Yu H.

Dev Neurosci. 2014;36(2):132-42. doi: 10.1159/000362363. Epub 2014 May 24.

7.

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins.

Zerenturk EJ, Sharpe LJ, Brown AJ.

Biochim Biophys Acta. 2012 Oct;1821(10):1350-60. doi: 10.1016/j.bbalip.2012.07.006. Epub 2012 Jul 15.

PMID:
22809995
8.

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Rodríguez-Acebes S, de la Cueva P, Fernández-Hernando C, Ferruelo AJ, Lasunción MA, Rawson RB, Martínez-Botas J, Gómez-Coronado D.

Biochem J. 2009 May 13;420(2):305-15. doi: 10.1042/BJ20081909.

9.

3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis.

Lu X, Kambe F, Cao X, Kozaki Y, Kaji T, Ishii T, Seo H.

Endocrinology. 2008 Jul;149(7):3267-73. doi: 10.1210/en.2008-0024. Epub 2008 Mar 13.

PMID:
18339707
10.

Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.

Daimiel LA, Fernández-Suárez ME, Rodríguez-Acebes S, Crespo L, Lasunción MA, Gómez-Coronado D, Martínez-Botas J.

Biosci Rep. 2012 Dec 6;33(1):57-69. doi: 10.1042/BSR20120095.

11.

Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.

Saito M, Kohara M, Tsukiyama-Kohara K.

J Med Virol. 2012 May;84(5):733-46. doi: 10.1002/jmv.23250.

PMID:
22431021
12.

DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.

Di Stasi D, Vallacchi V, Campi V, Ranzani T, Daniotti M, Chiodini E, Fiorentini S, Greeve I, Prinetti A, Rivoltini L, Pierotti MA, Rodolfo M.

Int J Cancer. 2005 Jun 10;115(2):224-30.

13.

DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis.

Mirza R, Hayasaka S, Takagishi Y, Kambe F, Ohmori S, Maki K, Yamamoto M, Murakami K, Kaji T, Zadworny D, Murata Y, Seo H.

J Invest Dermatol. 2006 Mar;126(3):638-47.

14.

3 β-hydroxysteroid-Δ 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress.

Lu X, Li Y, Wang W, Chen S, Liu T, Jia D, Quan X, Sun D, Chang AK, Gao B.

PLoS One. 2014 Jan 29;9(1):e86753. doi: 10.1371/journal.pone.0086753. eCollection 2014.

15.

Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.

Heverin M, Meaney S, Brafman A, Shafir M, Olin M, Shafaati M, von Bahr S, Larsson L, Lövgren-Sandblom A, Diczfalusy U, Parini P, Feinstein E, Björkhem I.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2191-7. Epub 2007 Aug 30.

16.

E2012-induced cataract and its predictive biomarkers.

Nakano-Ito K, Fujikawa Y, Hihara T, Shinjo H, Kotani S, Suganuma A, Aoki T, Tsukidate K.

Toxicol Sci. 2014 Jan;137(1):249-58. doi: 10.1093/toxsci/kft224. Epub 2013 Oct 1.

PMID:
24085193
17.

New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm.

Peri A, Danza G, Benvenuti S, Luciani P, Deledda C, Rosati F, Cellai I, Serio M.

Front Neuroendocrinol. 2009 Jul;30(2):119-29. doi: 10.1016/j.yfrne.2009.03.006. Epub 2009 Apr 5. Review.

PMID:
19351544
18.

How essential is cholesterol?

Stevenson J, Brown AJ.

Biochem J. 2009 May 13;420(2):e1-4. doi: 10.1042/BJ20090445.

PMID:
19426142
19.

The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.

Lu X, Li Y, Liu J, Cao X, Wang X, Wang D, Seo H, Gao B.

J Mol Endocrinol. 2012 Jan 25;48(1):1-9. doi: 10.1530/JME-11-0132. Print 2012 Feb.

PMID:
22010141
20.

Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase.

Nishimura T, Kohara M, Izumi K, Kasama Y, Hirata Y, Huang Y, Shuda M, Mukaidani C, Takano T, Tokunaga Y, Nuriya H, Satoh M, Saito M, Kai C, Tsukiyama-Kohara K.

J Biol Chem. 2009 Dec 25;284(52):36442-52. doi: 10.1074/jbc.M109.043232. Epub 2009 Oct 27.

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