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Protective effect of Tanshinone IIA against infarct size and increased HMGB1, NFκB, GFAP and apoptosis consequent to transient middle cerebral artery occlusion.

Wang JG, Bondy SC, Zhou L, Yang FZ, Ding ZG, Hu Y, Tian Y, Wen PY, Luo H, Wang F, Li WW, Zhou J.

Neurochem Res. 2014 Feb;39(2):295-304. doi: 10.1007/s11064-013-1221-y. Epub 2013 Dec 23.


Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model.

Zhou L, Zhang J, Wang C, Sun Q.

Int J Immunopathol Pharmacol. 2017 Jun;30(2):123-129. doi: 10.1177/0394632017703274. Epub 2017 Apr 12.


Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8.

Zhou L, Bondy SC, Jian L, Wen P, Yang F, Luo H, Li W, Zhou J.

Neuroscience. 2015 Mar 12;288:105-11. doi: 10.1016/j.neuroscience.2014.12.028. Epub 2015 Jan 6.


[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].

Wen PY, Yang FZ, Wang F, Li WW, Zhou L, Huang LH, Zhou J.

Zhong Yao Cai. 2012 Oct;35(10):1628-32. Chinese.


Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats.

Chen Y, Wu X, Yu S, Lin X, Wu J, Li L, Zhao J, Zhao Y.

PLoS One. 2012;7(6):e40165. doi: 10.1371/journal.pone.0040165. Epub 2012 Jun 29.


Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats.

Chen Y, Wu X, Yu S, Fauzee NJ, Wu J, Li L, Zhao J, Zhao Y.

Biol Pharm Bull. 2012;35(2):164-70.


Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.

Wang Q, Wang F, Li X, Yang Q, Li X, Xu N, Huang Y, Zhang Q, Gou X, Chen S, Xiong L.

J Neuroinflammation. 2012 Jan 26;9:24. doi: 10.1186/1742-2094-9-24.


Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.

Tang Q, Han R, Xiao H, Shen J, Luo Q, Li J.

Brain Res. 2012 Dec 7;1488:81-91. doi: 10.1016/j.brainres.2012.09.034. Epub 2012 Oct 11.


PI3K/Akt pathway contributes to neuroprotective effect of Tongxinluo against focal cerebral ischemia and reperfusion injury in rats.

Yu ZH, Cai M, Xiang J, Zhang ZN, Zhang JS, Song XL, Zhang W, Bao J, Li WW, Cai DF.

J Ethnopharmacol. 2016 Apr 2;181:8-19. doi: 10.1016/j.jep.2016.01.028. Epub 2016 Jan 22.


Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model.

Bai S, Hu Z, Yang Y, Yin Y, Li W, Wu L, Fang M.

Anat Rec (Hoboken). 2016 Feb;299(2):256-66. doi: 10.1002/ar.23293. Epub 2015 Dec 9.


Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model.

Vahidinia Z, Alipour N, Atlasi MA, Naderian H, Beyer C, Azami Tameh A.

Neurol Res. 2017 Jan;39(1):54-64. Epub 2016 Nov 11.


Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats.

Gong G, Xiang L, Yuan L, Hu L, Wu W, Cai L, Yin L, Dong H.

PLoS One. 2014 Mar 4;9(3):e89450. doi: 10.1371/journal.pone.0089450. eCollection 2014.


HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats.

Tao X, Lu W, Deng J, Hu Z, Lei Q, Zhang J, Song T, Liu J, Zheng L, He J.

Neurol Res. 2015 Mar;37(3):229-37. doi: 10.1179/1743132814Y.0000000427. Epub 2014 Aug 1.


Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia-Reperfusion Injury.

Zheng L, Ding J, Wang J, Zhou C, Zhang W.

Anat Rec (Hoboken). 2016 Feb;299(2):246-55. doi: 10.1002/ar.23295. Epub 2015 Dec 29.


Tanshinone IIA Attenuates Chronic Pancreatitis-Induced Pain in Rats via Downregulation of HMGB1 and TRL4 Expression in the Spinal Cord.

Wang YS, Li YY, Wang LH, Kang Y, Zhang J, Liu ZQ, Wang K, Kaye AD, Chen L.

Pain Physician. 2015 Jul-Aug;18(4):E615-28.


Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation.

Xin Q, Cheng B, Pan Y, Liu H, Yang C, Chen J, Bai B.

Peptides. 2015 Jan;63:55-62. doi: 10.1016/j.peptides.2014.09.016. Epub 2014 Sep 30.


UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats.

Su D, Su Z, Wang J, Yang S, Ma J.

Anat Rec (Hoboken). 2009 Jun;292(6):854-61. doi: 10.1002/ar.20910.


Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake.

Zhang Y, Li W, Zhu S, Jundoria A, Li J, Yang H, Fan S, Wang P, Tracey KJ, Sama AE, Wang H.

Biochem Pharmacol. 2012 Dec 1;84(11):1492-500. doi: 10.1016/j.bcp.2012.09.015. Epub 2012 Sep 26.


Neuroprotection of Osthole against Cerebral Ischemia/Reperfusion Injury through an Anti-apoptotic Pathway in Rats.

Li K, Ding D, Zhang M.

Biol Pharm Bull. 2016;39(3):336-42. doi: 10.1248/bpb.b15-00699.

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