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Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis.

Kumar D, Karampinos DC, MacLeod TD, Lin W, Nardo L, Li X, Link TM, Majumdar S, Souza RB.

Osteoarthritis Cartilage. 2014 Feb;22(2):226-34. doi: 10.1016/j.joca.2013.12.005. Epub 2013 Dec 20.


Relationships between fatty infiltration in the thigh and calf in women with knee osteoarthritis.

Davison MJ, Maly MR, Adachi JD, Noseworthy MD, Beattie KA.

Aging Clin Exp Res. 2017 Apr;29(2):291-299. doi: 10.1007/s40520-016-0556-z. Epub 2016 Mar 10.


Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial.

Raynauld JP, Pelletier JP, Roubille C, Dorais M, Abram F, Li W, Wang Y, Fairley J, Cicuttini FM, Martel-Pelletier J.

Arthritis Care Res (Hoboken). 2015 Oct;67(10):1406-15. doi: 10.1002/acr.22590.


Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison.

Ruhdorfer AS, Dannhauer T, Wirth W, Cotofana S, Roemer F, Nevitt M, Eckstein F; OAI investigators.

Osteoarthritis Cartilage. 2014 Oct;22(10):1634-8. doi: 10.1016/j.joca.2014.06.002.


Thigh muscle cross-sectional areas and strength in advanced versus early painful osteoarthritis: an exploratory between-knee, within-person comparison in osteoarthritis initiative participants.

Ruhdorfer A, Dannhauer T, Wirth W, Hitzl W, Kwoh CK, Guermazi A, Hunter DJ, Benichou O, Eckstein F; Osteoarthritis Initiative Investigators.

Arthritis Care Res (Hoboken). 2013 Jul;65(7):1034-42. doi: 10.1002/acr.21965.


Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis.

Beattie KA, MacIntyre NJ, Ramadan K, Inglis D, Maly MR.

Arthritis Care Res (Hoboken). 2012 Jan;64(1):22-9. doi: 10.1002/acr.20628.


Obesity and knee osteoarthritis are not associated with impaired quadriceps specific strength in adults.

Segal NA, Zimmerman MB, Brubaker M, Torner JC.

PM R. 2011 Apr;3(4):314-23; quiz 323. doi: 10.1016/j.pmrj.2010.12.011.


Relationship of intermuscular fat volume in the thigh with knee extensor strength and physical performance in women at risk of or with knee osteoarthritis.

Maly MR, Calder KM, Macintyre NJ, Beattie KA.

Arthritis Care Res (Hoboken). 2013 Jan;65(1):44-52. doi: 10.1002/acr.21868.


Isometric quadriceps strength in women with mild, moderate, and severe knee osteoarthritis.

Palmieri-Smith RM, Thomas AC, Karvonen-Gutierrez C, Sowers MF.

Am J Phys Med Rehabil. 2010 Jul;89(7):541-8. doi: 10.1097/PHM.0b013e3181ddd5c3.


Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative.

Stehling C, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM.

Osteoarthritis Cartilage. 2010 Jun;18(6):776-86. doi: 10.1016/j.joca.2010.02.008. Epub 2010 Feb 14.


Lean muscle volume of the thigh has a stronger relationship with muscle power than muscle strength in women with knee osteoarthritis.

Davison MJ, Maly MR, Keir PJ, Hapuhennedige SM, Kron AT, Adachi JD, Beattie KA.

Clin Biomech (Bristol, Avon). 2017 Jan;41:92-97. doi: 10.1016/j.clinbiomech.2016.11.005. Epub 2016 Nov 25.


Quadriceps/hamstrings co-activation increases early after total knee arthroplasty.

Thomas AC, Judd DL, Davidson BS, Eckhoff DG, Stevens-Lapsley JE.

Knee. 2014 Dec;21(6):1115-9. doi: 10.1016/j.knee.2014.08.001. Epub 2014 Sep 11.


Association of thigh muscle strength with knee symptoms and radiographic disease stage of osteoarthritis: data from the Osteoarthritis Initiative.

Ruhdorfer A, Wirth W, Hitzl W, Nevitt M, Eckstein F; Osteoarthritis Initiative Investigators.

Arthritis Care Res (Hoboken). 2014 Sep;66(9):1344-53. doi: 10.1002/acr.22317.


Effect of quadriceps strength and proprioception on risk for knee osteoarthritis.

Segal NA, Glass NA, Felson DT, Hurley M, Yang M, Nevitt M, Lewis CE, Torner JC.

Med Sci Sports Exerc. 2010 Nov;42(11):2081-8. doi: 10.1249/MSS.0b013e3181dd902e.


Factors associated with arthrogenous muscle inhibition in patellofemoral osteoarthritis.

Callaghan MJ, Parkes MJ, Hutchinson CE, Felson DT.

Osteoarthritis Cartilage. 2014 Jun;22(6):742-6. doi: 10.1016/j.joca.2014.03.015. Epub 2014 Mar 29.


Weak associations between structural changes on MRI and symptoms, function and muscle strength in relation to knee osteoarthritis.

Baert IA, Staes F, Truijen S, Mahmoudian A, Noppe N, Vanderschueren G, Luyten FP, Verschueren SM.

Knee Surg Sports Traumatol Arthrosc. 2014 Sep;22(9):2013-25. doi: 10.1007/s00167-013-2434-y. Epub 2013 Feb 2.


Thigh muscle strength, functional capacity, and self-reported function in patients at high risk of knee osteoarthritis compared with controls.

Thorlund JB, Aagaard P, Roos EM.

Arthritis Care Res (Hoboken). 2010 Sep;62(9):1244-51. doi: 10.1002/acr.20201.


Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis.

Amin S, Baker K, Niu J, Clancy M, Goggins J, Guermazi A, Grigoryan M, Hunter DJ, Felson DT.

Arthritis Rheum. 2009 Jan;60(1):189-98. doi: 10.1002/art.24182.


Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain - data from the osteoarthritis initiative.

Sattler M, Dannhauer T, Hudelmaier M, Wirth W, Sänger AM, Kwoh CK, Hunter DJ, Eckstein F; OAI investigators.

Osteoarthritis Cartilage. 2012 Jun;20(6):532-40. doi: 10.1016/j.joca.2012.02.635. Epub 2012 Mar 3.


Impact of pain reported during isometric quadriceps muscle strength testing in people with knee pain: data from the osteoarthritis initiative.

Riddle DL, Stratford PW.

Phys Ther. 2011 Oct;91(10):1478-89. doi: 10.2522/ptj.20110034. Epub 2011 Aug 11. Erratum in: Phys Ther. 2011 Nov;91(11):1696.

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