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Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling.

Moyes DL, Shen C, Murciano C, Runglall M, Richardson JP, Arno M, Aldecoa-Otalora E, Naglik JR.

J Infect Dis. 2014 Jun 1;209(11):1816-26. doi: 10.1093/infdis/jit824. Epub 2013 Dec 19.


Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae.

Moyes DL, Murciano C, Runglall M, Kohli A, Islam A, Naglik JR.

Med Microbiol Immunol. 2012 Feb;201(1):93-101. doi: 10.1007/s00430-011-0209-y. Epub 2011 Jun 25.


Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A.

J Biol Chem. 2009 Feb 13;284(7):4052-61. doi: 10.1074/jbc.M805032200. Epub 2008 Dec 13.


Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.

Moyes DL, Murciano C, Runglall M, Islam A, Thavaraj S, Naglik JR.

PLoS One. 2011;6(11):e26580. doi: 10.1371/journal.pone.0026580. Epub 2011 Nov 8.


A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.

Moyes DL, Runglall M, Murciano C, Shen C, Nayar D, Thavaraj S, Kohli A, Islam A, Mora-Montes H, Challacombe SJ, Naglik JR.

Cell Host Microbe. 2010 Sep 16;8(3):225-35. doi: 10.1016/j.chom.2010.08.002.


Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease.

Long SH, He Y, Chen MH, Cao K, Chen YJ, Chen BL, Mao R, Zhang SH, Zhu ZH, Zeng ZR, Hu PJ.

J Dig Dis. 2013 Dec;14(12):662-9. doi: 10.1111/1751-2980.12095.


RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA.

Cancer Res. 2009 May 15;69(10):4107-11. doi: 10.1158/0008-5472.CAN-09-0474. Epub 2009 May 12.


Glutamine modulates lipopolysaccharide-induced activation of NF-κB via the Akt/mTOR pathway in lung epithelial cells.

Hou YC, Chiu WC, Yeh CL, Yeh SL.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L174-83. doi: 10.1152/ajplung.00066.2011. Epub 2011 Oct 14.


A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

Korkolopoulou P, Levidou G, Trigka EA, Prekete N, Karlou M, Thymara I, Sakellariou S, Fragkou P, Isaiadis D, Pavlopoulos P, Patsouris E, Saetta AA.

BJU Int. 2012 Dec;110(11 Pt C):E1237-48. doi: 10.1111/j.1464-410X.2012.11569.x. Epub 2012 Oct 29.


A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy.

Goodman CA, Miu MH, Frey JW, Mabrey DM, Lincoln HC, Ge Y, Chen J, Hornberger TA.

Mol Biol Cell. 2010 Sep 15;21(18):3258-68. doi: 10.1091/mbc.E10-05-0454. Epub 2010 Jul 28.


Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.

Xu Z, Zhang Y, Jiang J, Yang Y, Shi R, Hao B, Zhang Z, Huang Z, Kim JW, Zhang G.

BMC Cancer. 2010 Apr 27;10:161. doi: 10.1186/1471-2407-10-161.


KCa3.1 mediates dysfunction of tubular autophagy in diabetic kidneys via PI3k/Akt/mTOR signaling pathways.

Huang C, Lin MZ, Cheng D, Braet F, Pollock CA, Chen XM.

Sci Rep. 2016 Mar 31;6:23884. doi: 10.1038/srep23884.


Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells.

Zhang Q, Zhu H, Xu X, Li L, Tan H, Cai X.

Biochem Biophys Res Commun. 2015 Sep 11;465(1):64-70. doi: 10.1016/j.bbrc.2015.07.130. Epub 2015 Jul 30.


Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.

Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N.

J Biol Chem. 2015 Feb 20;290(8):5190-202. doi: 10.1074/jbc.M114.591610. Epub 2015 Jan 6.


Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B.

Rafiee P, Binion DG, Wellner M, Behmaram B, Floer M, Mitton E, Nie L, Zhang Z, Otterson MF.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G865-77. doi: 10.1152/ajpgi.00339.2009. Epub 2010 Mar 18.


Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines.

Wang L, Wu J, Lu J, Ma R, Sun D, Tang J.

Mol Med Rep. 2015 Feb;11(2):931-9. doi: 10.3892/mmr.2014.2819. Epub 2014 Oct 30.

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