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Role of the goat K222-PrP(C) polymorphic variant in prion infection resistance.

Aguilar-Calvo P, Espinosa JC, Pintado B, Gutiérrez-Adán A, Alamillo E, Miranda A, Prieto I, Bossers A, Andreoletti O, Torres JM.

J Virol. 2014 Mar;88(5):2670-6. doi: 10.1128/JVI.02074-13.


Effect of Q211 and K222 PRNP Polymorphic Variants in the Susceptibility of Goats to Oral Infection With Goat Bovine Spongiform Encephalopathy.

Aguilar-Calvo P, Fast C, Tauscher K, Espinosa JC, Groschup MH, Nadeem M, Goldmann W, Langeveld J, Bossers A, Andreoletti O, Torres JM.

J Infect Dis. 2015 Aug 15;212(4):664-72. doi: 10.1093/infdis/jiv112.


Goat K222-PrPC polymorphic variant does not provide resistance to atypical scrapie in transgenic mice.

Aguilar-Calvo P, Espinosa JC, Andréoletti O, González L, Orge L, Juste R, Torres JM.

Vet Res. 2016 Sep 22;47(1):96.


Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversion studies.

Priem J, Langeveld JP, van Keulen LJ, van Zijderveld FG, Andreoletti O, Bossers A.

J Virol. 2014 Mar;88(5):2903-12. doi: 10.1128/JVI.02446-13.


Genetic resistance to scrapie infection in experimentally challenged goats.

Lacroux C, Perrin-Chauvineau C, Corbière F, Aron N, Aguilar-Calvo P, Torres JM, Costes P, Brémaud I, Lugan S, Schelcher F, Barillet F, Andréoletti O.

J Virol. 2014 Mar;88(5):2406-13. doi: 10.1128/JVI.02872-13.


Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.

Acutis PL, Martucci F, D'Angelo A, Peletto S, Colussi S, Maurella C, Porcario C, Iulini B, Mazza M, Dell'atti L, Zuccon F, Corona C, Martinelli N, Casalone C, Caramelli M, Lombardi G.

Vet Res. 2012 Feb 1;43:8. doi: 10.1186/1297-9716-43-8.


Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.

Langeveld JP, Jacobs JG, Hunter N, van Keulen LJ, Lantier F, van Zijderveld FG, Bossers A.

J Virol. 2015 Oct 28;90(2):805-12. doi: 10.1128/JVI.02316-15.


Transmission and characterization of bovine spongiform encephalopathy sources in two ovine transgenic mouse lines (TgOvPrP4 and TgOvPrP59).

Cordier C, Bencsik A, Philippe S, Bétemps D, Ronzon F, Calavas D, Crozet C, Baron T.

J Gen Virol. 2006 Dec;87(Pt 12):3763-71.


Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice.

Padilla D, Béringue V, Espinosa JC, Andreoletti O, Jaumain E, Reine F, Herzog L, Gutierrez-Adan A, Pintado B, Laude H, Torres JM.

PLoS Pathog. 2011 Mar;7(3):e1001319. doi: 10.1371/journal.ppat.1001319.


Experimental interspecies transmission studies of the transmissible spongiform encephalopathies to cattle: comparison to bovine spongiform encephalopathy in cattle.

Hamir AN, Kehrli ME Jr, Kunkle RA, Greenlee JJ, Nicholson EM, Richt JA, Miller JM, Cutlip RC.

J Vet Diagn Invest. 2011 May;23(3):407-20. doi: 10.1177/1040638711403404. Review.


Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein.

Wilson R, Plinston C, Hunter N, Casalone C, Corona C, Tagliavini F, Suardi S, Ruggerone M, Moda F, Graziano S, Sbriccoli M, Cardone F, Pocchiari M, Ingrosso L, Baron T, Richt J, Andreoletti O, Simmons M, Lockey R, Manson JC, Barron RM.

J Gen Virol. 2012 Jul;93(Pt 7):1624-9. doi: 10.1099/vir.0.042507-0.


Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies.

Jeffrey M, Martin S, González L, Foster J, Langeveld JP, van Zijderveld FG, Grassi J, Hunter N.

J Comp Pathol. 2006 Feb-Apr;134(2-3):171-81.


Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.

Vaccari G, D'Agostino C, Nonno R, Rosone F, Conte M, Di Bari MA, Chiappini B, Esposito E, De Grossi L, Giordani F, Marcon S, Morelli L, Borroni R, Agrimi U.

J Virol. 2007 Jul;81(13):7306-9.


Genetic and Pathological Follow-Up Study of Goats Experimentally and Naturally Exposed to a Sheep Scrapie Isolate.

Maestrale C, Cancedda MG, Pintus D, Masia M, Nonno R, Ru G, Carta A, Demontis F, Santucciu C, Ligios C.

J Virol. 2015 Oct;89(19):10044-52. doi: 10.1128/JVI.01262-15.


Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222.

White SN, Reynolds JO, Waldron DF, Schneider DA, O'Rourke KI.

Gene. 2012 Jun 10;501(1):49-51. doi: 10.1016/j.gene.2012.03.068.


Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds.

Goldmann W, Marier E, Stewart P, Konold T, Street S, Langeveld J, Windl O, Ortiz-Pelaez A.

Vet Rec. 2016 Feb 13;178(7):168. doi: 10.1136/vr.103521.


Prion encephalopathies of animals and humans.

Prusiner SB.

Dev Biol Stand. 1993;80:31-44. Review.

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