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Items: 1 to 20 of 112

1.

Alteration of dynein function affects α-synuclein degradation via the autophagosome-lysosome pathway.

Li D, Shi JJ, Mao CJ, Liu S, Wang JD, Chen J, Wang F, Yang YP, Hu WD, Hu LF, Liu CF.

Int J Mol Sci. 2013 Dec 13;14(12):24242-54. doi: 10.3390/ijms141224242.

2.

MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein.

Cai ZL, Shi JJ, Yang YP, Cao BY, Wang F, Huang JZ, Yang F, Zhang P, Liu CF.

Neuroreport. 2009 Apr 22;20(6):569-73. doi: 10.1097/WNR.0b013e32832986c4.

PMID:
19287320
3.

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells.

Wang MX, Cheng XY, Jin M, Cao YL, Yang YP, Wang JD, Li Q, Wang F, Hu LF, Liu CF.

Exp Neurol. 2015 Sep;271:112-21. doi: 10.1016/j.expneurol.2015.05.008. Epub 2015 May 19.

PMID:
26001614
4.

p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions.

Watanabe Y, Tatebe H, Taguchi K, Endo Y, Tokuda T, Mizuno T, Nakagawa M, Tanaka M.

PLoS One. 2012;7(12):e52868. doi: 10.1371/journal.pone.0052868. Epub 2012 Dec 31.

5.

Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.

Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.

J Biol Chem. 2013 Jun 14;288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29.

6.

The effects of dynein inhibition on the autophagic pathway in glioma cells.

Yamamoto M, Suzuki SO, Himeno M.

Neuropathology. 2010 Feb 1;30(1):1-6. doi: 10.1111/j.1440-1789.2009.01034.x. Epub 2009 Jun 3.

PMID:
19496938
7.

Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.

Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL.

Biochim Biophys Acta. 2013 Dec;1833(12):3228-3236. doi: 10.1016/j.bbamcr.2013.09.015. Epub 2013 Oct 1.

8.

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.

9.

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.

Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D.

Science. 2004 Aug 27;305(5688):1292-5.

10.

Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.

Sala G, Arosio A, Stefanoni G, Melchionda L, Riva C, Marinig D, Brighina L, Ferrarese C.

Biomed Res Int. 2013;2013:846725. doi: 10.1155/2013/846725. Epub 2013 Jul 30.

11.

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.

Usenovic M, Tresse E, Mazzulli JR, Taylor JP, Krainc D.

J Neurosci. 2012 Mar 21;32(12):4240-6. doi: 10.1523/JNEUROSCI.5575-11.2012.

12.

Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells.

Wang K, Huang J, Xie W, Huang L, Zhong C, Chen Z.

Diagn Pathol. 2016 Jan 29;11:15. doi: 10.1186/s13000-016-0459-5.

14.

Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.

Wu F, Xu HD, Guan JJ, Hou YS, Gu JH, Zhen XC, Qin ZH.

Neuroscience. 2015 Jan 22;284:900-11. doi: 10.1016/j.neuroscience.2014.11.004. Epub 2014 Nov 13.

PMID:
25446361
15.

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells.

Jiang P, Mizushima N.

Methods. 2015 Mar;75:13-8. doi: 10.1016/j.ymeth.2014.11.021. Epub 2014 Dec 5.

PMID:
25484342
16.

Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation.

Hung KC, Huang HJ, Lin MW, Lei YP, Lin AM.

PLoS One. 2014 Mar 19;9(3):e91074. doi: 10.1371/journal.pone.0091074. eCollection 2014.

17.

Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy.

Sheng YL, Chen X, Hou XO, Yuan X, Yuan BS, Yuan YQ, Zhang QL, Cao X, Liu CF, Luo WF, Hu LF.

Exp Neurol. 2017 Nov;297:138-147. doi: 10.1016/j.expneurol.2017.08.007. Epub 2017 Aug 16.

PMID:
28821398
18.

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.

Xilouri M, Brekk OR, Stefanis L.

Mov Disord. 2016 Feb;31(2):178-92. doi: 10.1002/mds.26477. Epub 2016 Jan 27. Review.

PMID:
26813776
19.

Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.

Lan DM, Liu FT, Zhao J, Chen Y, Wu JJ, Ding ZT, Yue ZY, Ren HM, Jiang YP, Wang J.

Neurochem Res. 2012 Sep;37(9):2025-32. doi: 10.1007/s11064-012-0823-0. Epub 2012 Jun 17.

PMID:
22707286
20.

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26. doi: 10.1073/pnas.1305623110. Epub 2013 Apr 22.

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