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Items: 1 to 20 of 107

1.

EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.

Vella S, Gnani D, Crudele A, Ceccarelli S, De Stefanis C, Gaspari S, Nobili V, Locatelli F, Marquez VE, Rota R, Alisi A.

Int J Mol Sci. 2013 Dec 12;14(12):24154-68. doi: 10.3390/ijms141224154.

2.

Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway.

Zhang P, Yang X, Ma X, Ingram DR, Lazar AJ, Torres KE, Pollock RE.

Mol Cancer. 2015 Mar 7;14:55. doi: 10.1186/s12943-015-0325-1.

3.

EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.

Fu Y, Chen J, Pang B, Li C, Zhao J, Shen K.

Cell Biochem Biophys. 2015 Jan;71(1):105-12. doi: 10.1007/s12013-014-0168-1.

PMID:
25077680
4.

Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.

Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H.

Lung Cancer. 2012 Nov;78(2):138-43. doi: 10.1016/j.lungcan.2012.08.003. Epub 2012 Aug 25.

5.

Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis.

Au SL, Wong CC, Lee JM, Fan DN, Tsang FH, Ng IO, Wong CM.

Hepatology. 2012 Aug;56(2):622-31. doi: 10.1002/hep.25679. Epub 2012 Jun 11.

PMID:
22370893
6.

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.

Mitić T, Caporali A, Floris I, Meloni M, Marchetti M, Urrutia R, Angelini GD, Emanueli C.

Mol Ther. 2015 Jan;23(1):32-42. doi: 10.1038/mt.2014.163. Epub 2014 Sep 5.

7.

Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31.

Zhang Q, Padi SK, Tindall DJ, Guo B.

Cell Death Dis. 2014 Oct 23;5:e1486. doi: 10.1038/cddis.2014.454.

8.

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

Floris I, Descamps B, Vardeu A, Mitić T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):664-74. doi: 10.1161/ATVBAHA.114.304730. Epub 2015 Jan 22.

9.

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

Tsang DP, Wu WK, Kang W, Lee YY, Wu F, Yu Z, Xiong L, Chan AW, Tong JH, Yang W, Li MS, Lau SS, Li X, Lee SD, Yang Y, Lai PB, Yu DY, Xu G, Lo KW, Chan MT, Wang H, Lee TL, Yu J, Wong N, Yip KY, To KF, Cheng AS.

J Pathol. 2016 Apr;238(5):651-64. doi: 10.1002/path.4688.

PMID:
26800240
10.

Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.

Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, Cloos J, Breakefield XO, Krichevsky AM, Noske DP, Tannous BA, Würdinger T.

PLoS One. 2011 Jan 28;6(1):e16282. doi: 10.1371/journal.pone.0016282.

11.

MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2.

Ma DN, Chai ZT, Zhu XD, Zhang N, Zhan DH, Ye BG, Wang CH, Qin CD, Zhao YM, Zhu WP, Cao MQ, Gao DM, Sun HC, Tang ZY.

J Hematol Oncol. 2016 Jan 6;9:1. doi: 10.1186/s13045-015-0229-y.

12.

Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.

Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, Dosaka-Akita H.

Cancer Sci. 2016 Jul;107(7):955-62. doi: 10.1111/cas.12957. Epub 2016 Jun 13.

13.

DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.

Ning X, Shi Z, Liu X, Zhang A, Han L, Jiang K, Kang C, Zhang Q.

Cancer Lett. 2015 Apr 10;359(2):198-205. doi: 10.1016/j.canlet.2015.01.005. Epub 2015 Jan 13.

PMID:
25595591
14.

MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity.

Xu L, Beckebaum S, Iacob S, Wu G, Kaiser GM, Radtke A, Liu C, Kabar I, Schmidt HH, Zhang X, Lu M, Cicinnati VR.

J Hepatol. 2014 Mar;60(3):590-8. doi: 10.1016/j.jhep.2013.10.028. Epub 2013 Nov 6.

PMID:
24211739
15.

Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.

Gannon OM, Merida de Long L, Endo-Munoz L, Hazar-Rethinam M, Saunders NA.

Clin Cancer Res. 2013 Jan 15;19(2):428-41. doi: 10.1158/1078-0432.CCR-12-2505. Epub 2012 Nov 27.

16.

MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer.

Zhang H, Zhang H, Zhao M, Lv Z, Zhang X, Qin X, Wang H, Wang S, Su J, Lv X, Liu H, Du W, Zhou W, Chen X, Fei K.

Cell Physiol Biochem. 2013;31(1):56-65. doi: 10.1159/000343349. Epub 2013 Jan 15.

17.

Quantitative nuclear proteomics identifies that miR-137-mediated EZH2 reduction regulates resveratrol-induced apoptosis of neuroblastoma cells.

Ren X, Bai X, Zhang X, Li Z, Tang L, Zhao X, Li Z, Ren Y, Wei S, Wang Q, Liu C, Ji J.

Mol Cell Proteomics. 2015 Feb;14(2):316-28. doi: 10.1074/mcp.M114.041905. Epub 2014 Dec 11.

18.

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.

Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B.

Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.

PMID:
23932971
19.

A double-negative feedback loop between EZH2 and miR-26a regulates tumor cell growth in hepatocellular carcinoma.

Zhuang C, Wang P, Huang D, Xu L, Wang X, Wang L, Hu L.

Int J Oncol. 2016 Mar;48(3):1195-204. doi: 10.3892/ijo.2016.3336. Epub 2016 Jan 13.

PMID:
26781064
20.

MiR-340 impedes the progression of laryngeal squamous cell carcinoma by targeting EZH2.

Yu W, Zhang G, Lu B, Li J, Wu Z, Ma H, Wang H, Lian R.

Gene. 2016 Feb 15;577(2):193-201. doi: 10.1016/j.gene.2015.11.045. Epub 2015 Dec 2.

PMID:
26656176

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