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Items: 1 to 20 of 96

1.

Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyindole analogs through environment friendly reaction.

Das SK, Bhattacharya S, Kundu A.

J Adv Pharm Technol Res. 2013 Oct;4(4):198-205. doi: 10.4103/2231-4040.121414.

2.

Scaffold-inspired enantioselective synthesis of biologically important spiro[pyrrolidin-3,2'-oxindoles] with structural diversity through catalytic isatin-derived 1,3-dipolar cycloadditions.

Shi F, Tao ZL, Luo SW, Tu SJ, Gong LZ.

Chemistry. 2012 May 29;18(22):6885-94. doi: 10.1002/chem.201200358. Epub 2012 Apr 13.

PMID:
22505189
3.

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation.

Sharma P, Senwar KR, Jeengar MK, Reddy TS, Naidu VG, Kamal A, Shankaraiah N.

Eur J Med Chem. 2015 Nov 2;104:11-24. doi: 10.1016/j.ejmech.2015.09.025. Epub 2015 Sep 16.

PMID:
26413726
4.

Synthesis of pyrrolo(spiro-[2.3']-oxindole)-spiro-[4.3"]-oxindole via 1,3-dipolar cycloaddition of azomethine ylides with 3-acetonylideneoxindole.

Xiao JA, Zhang HG, Liang S, Ren JW, Yang H, Chen XQ.

J Org Chem. 2013 Nov 15;78(22):11577-83. doi: 10.1021/jo4017259. Epub 2013 Oct 24.

PMID:
24111532
5.

Total synthesis and biological evaluation of spirotryprostatin A analogs.

Ma Y, Fan C, Jia B, Cheng P, Liu J, Ma Y, Qiao K.

Chirality. 2017 Nov;29(11):737-746. doi: 10.1002/chir.22746. Epub 2017 Sep 14.

PMID:
28906026
6.

Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione.

Sun Y, Sun J, Yan CG.

Beilstein J Org Chem. 2013;9:8-14. doi: 10.3762/bjoc.9.2. Epub 2013 Jan 3.

7.

Catalytic asymmetric construction of spiro[pyrrolidine-2,3'-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles.

Zhu G, Wang B, Bao X, Zhang H, Wei Q, Qu J.

Chem Commun (Camb). 2015 Nov 4;51(85):15510-3. doi: 10.1039/c5cc05798a.

PMID:
26345264
9.

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles.

Sumesh RV, Muthu M, Almansour AI, Suresh Kumar R, Arumugam N, Athimoolam S, Jeya Yasmi Prabha EA, Kumar RR.

ACS Comb Sci. 2016 May 9;18(5):262-70. doi: 10.1021/acscombsci.6b00003. Epub 2016 Apr 8.

PMID:
27027478
10.

Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents.

Yu B, Shi XJ, Qi PP, Yu DQ, Liu HM.

J Steroid Biochem Mol Biol. 2014 May;141:121-34. doi: 10.1016/j.jsbmb.2014.01.015. Epub 2014 Feb 6. Erratum in: J Steroid Biochem Mol Biol. 2015 Mar;147():124.

PMID:
24508598
11.

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives.

Tian L, Hu XQ, Li YH, Xu PF.

Chem Commun (Camb). 2013 Aug 21;49(65):7213-5. doi: 10.1039/c3cc43755h. Epub 2013 Jul 10.

PMID:
23838686
12.
13.

Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity.

Chen XH, Wei Q, Luo SW, Xiao H, Gong LZ.

J Am Chem Soc. 2009 Sep 30;131(38):13819-25. doi: 10.1021/ja905302f.

PMID:
19736987
14.

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction.

Fu Q, Yan CG.

Beilstein J Org Chem. 2013 May 13;9:918-24. doi: 10.3762/bjoc.9.105. Print 2013.

15.

Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines.

Monteiro Â, Gonçalves LM, Santos MM.

Eur J Med Chem. 2014 May 22;79:266-72. doi: 10.1016/j.ejmech.2014.04.023. Epub 2014 Apr 8.

PMID:
24747063
16.
17.

Catalytic enantioselective amide allylation of isatins and its application in the synthesis of 2-oxindole derivatives spiro-fused to the α-methylene-γ-butyrolactone functionality.

Takahashi M, Murata Y, Yagishita F, Sakamoto M, Sengoku T, Yoda H.

Chemistry. 2014 Aug 25;20(35):11091-100. doi: 10.1002/chem.201403357. Epub 2014 Jul 22.

PMID:
25049083
18.

Asymmetric catalytic 1,3-dipolar cycloaddition reaction of nitrile imines for the synthesis of chiral spiro-pyrazoline-oxindoles.

Wang G, Liu X, Huang T, Kuang Y, Lin L, Feng X.

Org Lett. 2013 Jan 4;15(1):76-9. doi: 10.1021/ol303097j. Epub 2012 Dec 10.

PMID:
23228061
19.

Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines.

Raj AA, Raghunathan R, SrideviKumari MR, Raman N.

Bioorg Med Chem. 2003 Feb 6;11(3):407-19.

PMID:
12517436
20.

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