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NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOII╬▒-mediated decatenation checkpoint.

Ando K, Ozaki T, Hirota T, Nakagawara A.

PLoS One. 2013 Dec 11;8(12):e82744. doi: 10.1371/journal.pone.0082744. eCollection 2013.


NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells.

Bu Y, Suenaga Y, Okoshi R, Sang M, Kubo N, Song F, Nakagawara A, Ozaki T.

Biochem Biophys Res Commun. 2010 Jun 25;397(2):157-62. doi: 10.1016/j.bbrc.2010.05.063. Epub 2010 Jun 1.


Plk1-dependent phosphorylation regulates functions of DNA topoisomerase IIalpha in cell cycle progression.

Li H, Wang Y, Liu X.

J Biol Chem. 2008 Mar 7;283(10):6209-21. doi: 10.1074/jbc.M709007200. Epub 2008 Jan 2.


Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

Ismail IA, Kang KS, Lee HA, Kim JW, Sohn YK.

Eur J Pharmacol. 2007 Dec 1;575(1-3):12-20. Epub 2007 Jul 28.


Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.

Bower JJ, Zhou Y, Zhou T, Simpson DA, Arlander SJ, Paules RS, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2010 Apr 15;9(8):1617-28. Epub 2010 Apr 15.


Geminin overexpression prevents the completion of topoisomerase II╬▒ chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.

Gardner L, Malik R, Shimizu Y, Mullins N, ElShamy WM.

Breast Cancer Res. 2011 May 19;13(3):R53. doi: 10.1186/bcr2884.


Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

Iida M, Matsuda M, Komatani H.

Biochem J. 2008 Apr 1;411(1):27-32.


Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.

Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O.

J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.


ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.

Deming PB, Flores KG, Downes CS, Paules RS, Kaufmann WK.

J Biol Chem. 2002 Sep 27;277(39):36832-8. Epub 2002 Jul 29.


MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.


Topoisomerase IIalpha controls the decatenation checkpoint.

Luo K, Yuan J, Chen J, Lou Z.

Nat Cell Biol. 2009 Feb;11(2):204-10. doi: 10.1038/ncb1828. Epub 2008 Dec 21.


NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.

Wilson KA, Colavito SA, Schulz V, Wakefield PH, Sessa W, Tuck D, Stern DF.

Mol Cancer Res. 2011 Jun;9(6):766-81. doi: 10.1158/1541-7786.MCR-10-0317. Epub 2011 May 6.


A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB.

PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287.


Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.

Shin SB, Woo SU, Yim H.

J Cell Physiol. 2015 Dec;230(12):3057-67. doi: 10.1002/jcp.25042.


Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.

Jang YJ, Ji JH, Choi YC, Ryu CJ, Ko SY.

J Biol Chem. 2007 Jan 26;282(4):2473-82. Epub 2006 Nov 22.


Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.

Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.

J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 Jan 3.


STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.

Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A.

J Cell Sci. 2005 Apr 15;118(Pt 8):1629-39. Epub 2005 Mar 22. Retraction in: J Cell Sci. 2015 Mar 1;128(5):1064.

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