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Items: 1 to 20 of 115

1.

C-terminus of the B-chain of relaxin-3 is important for receptor activity.

Shabanpoor F, Bathgate RA, Wade JD, Hossain MA.

PLoS One. 2013 Dec 11;8(12):e82567. doi: 10.1371/journal.pone.0082567. eCollection 2013.

2.

The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.

Wang XY, Guo YQ, Zhang WJ, Shao XX, Liu YL, Xu ZG, Guo ZY.

FEBS J. 2014 Jul;281(13):2927-36. doi: 10.1111/febs.12830. Epub 2014 May 27.

3.

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.

Patil NA, Bathgate RA, Kocan M, Ang SY, Tailhades J, Separovic F, Summers R, Grosse J, Hughes RA, Wade JD, Hossain MA.

Amino Acids. 2016 Apr;48(4):987-92. doi: 10.1007/s00726-015-2144-5. Epub 2015 Dec 11.

PMID:
26661035
4.

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.

Hossain MA, Bathgate RA, Rosengren KJ, Shabanpoor F, Zhang S, Lin F, Tregear GW, Wade JD.

Chem Biol Drug Des. 2009 Jan;73(1):46-52. doi: 10.1111/j.1747-0285.2008.00756.x.

PMID:
19152634
5.

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity.

Hossain MA, Rosengren KJ, Zhang S, Bathgate RA, Tregear GW, van Lierop BJ, Robinson AJ, Wade JD.

Org Biomol Chem. 2009 Apr 21;7(8):1547-53. doi: 10.1039/b821882j. Epub 2009 Feb 24.

PMID:
19343240
6.

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.

Liu C, Kuei C, Sutton S, Shelton J, Zhu J, Nepomuceno D, Hossain MA, Wade JD, Bathgate RA, Bonaventure P, Lovenberg T.

Ann N Y Acad Sci. 2009 Apr;1160:31-7. doi: 10.1111/j.1749-6632.2008.03790.x.

PMID:
19416155
7.

Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.

Wang XY, Guo YQ, Shao XX, Liu YL, Xu ZG, Guo ZY.

Arch Biochem Biophys. 2014 Sep 15;558:127-32. doi: 10.1016/j.abb.2014.07.010. Epub 2014 Jul 18.

PMID:
25043977
8.

Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies.

Zhang WJ, Luo X, Liu YL, Shao XX, Wade JD, Bathgate RA, Guo ZY.

Amino Acids. 2012 Aug;43(2):983-92. doi: 10.1007/s00726-011-1164-z. Epub 2011 Dec 21.

PMID:
22187146
9.

The roles of the A- and B-chains of human relaxin-2 and -3 on their biological activity.

Hossain MA, Wade JD.

Curr Protein Pept Sci. 2010 Dec;11(8):719-24. Review.

PMID:
21235507
10.

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.

Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA.

J Biol Chem. 2008 Jun 20;283(25):17287-97. doi: 10.1074/jbc.M801911200. Epub 2008 Apr 22.

11.

Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.

Hu MJ, Shao XX, Wang JH, Wei D, Liu YL, Xu ZG, Guo ZY.

Amino Acids. 2016 Sep;48(9):2227-36. doi: 10.1007/s00726-016-2260-x. Epub 2016 May 19.

PMID:
27193232
12.

In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.

Alvarez-Jaimes L, Sutton SW, Nepomuceno D, Motley ST, Cik M, Stocking E, Shoblock J, Bonaventure P.

PLoS One. 2012;7(2):e30792. doi: 10.1371/journal.pone.0030792. Epub 2012 Feb 7.

13.

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.

Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA, Separovic F, Wade JD.

J Med Chem. 2012 Feb 23;55(4):1671-81. doi: 10.1021/jm201505p. Epub 2012 Feb 8.

PMID:
22257012
15.

A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays.

Zhang WJ, Jiang Q, Wang XY, Song G, Shao XX, Guo ZY.

J Pept Sci. 2013 Jun;19(6):350-4. doi: 10.1002/psc.2507. Epub 2013 Mar 22.

PMID:
23526726
16.

Structure and activity in the relaxin family of peptides.

Tregear GW, Bathgate RA, Hossain MA, Lin F, Zhang S, Shabanpoor F, Scott DJ, Ma S, Gundlach AL, Samuel CS, Wade JD.

Ann N Y Acad Sci. 2009 Apr;1160:5-10. doi: 10.1111/j.1749-6632.2009.03955.x.

PMID:
19416150
17.

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability.

Hossain MA, Haugaard-Kedström LM, Rosengren KJ, Bathgate RA, Wade JD.

Org Biomol Chem. 2015 Nov 28;13(44):10895-903. doi: 10.1039/c5ob01539a. Epub 2015 Sep 14.

PMID:
26368576
18.

Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).

Zhu J, Kuei C, Sutton S, Kamme F, Yu J, Bonaventure P, Atack J, Lovenberg TW, Liu C.

Eur J Pharmacol. 2008 Aug 20;590(1-3):43-52. doi: 10.1016/j.ejphar.2008.05.025. Epub 2008 May 27.

PMID:
18582868
19.

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways.

Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ.

Br J Pharmacol. 2007 Mar;150(6):677-91. Epub 2007 Feb 12. Review.

20.

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

Rosengren KJ, Lin F, Bathgate RA, Tregear GW, Daly NL, Wade JD, Craik DJ.

J Biol Chem. 2006 Mar 3;281(9):5845-51. Epub 2005 Dec 19.

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