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Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.

Mawatari S, Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H.

PLoS One. 2013 Dec 12;8(12):e82094. doi: 10.1371/journal.pone.0082094. eCollection 2013.


A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.

Franco S, Clotet B, Martínez MA.

Virus Res. 2008 Feb;131(2):260-70. Epub 2007 Nov 26.


DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.

Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB.

Virology. 2013 Jan 20;435(2):385-94. doi: 10.1016/j.virol.2012.10.025. Epub 2012 Nov 5.


Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.

McGivern DR, Masaki T, Lovell W, Hamlett C, Saalau-Bethell S, Graham B.

J Virol. 2015 May;89(10):5362-70. doi: 10.1128/JVI.03188-14. Epub 2015 Mar 4.


Hepatitis C virus NS3/4A quasispecies diversity in acute hepatitis C infection in HIV-1 co-infected patients.

Nevot M, Boesecke C, Parera M, Andrés C, Franco S, Revollo B, Ingiliz P, Tural C, Clotet B, Rockstroh JK, Martinez MA; NEAT study group.

J Viral Hepat. 2014 Jun;21(6):e19-28. doi: 10.1111/jvh.12254. Epub 2014 Mar 27.


Development of a cell-based assay for monitoring hepatitis C virus ns3/4a protease activity.

Lei YF, Yin W, Yang J, Lv X, Wei SH, An QX, Hu XB, Xu ZK.

Acta Virol. 2008;52(3):133-41.


Complexity and catalytic efficiency of hepatitis C virus (HCV) NS3 and NS4A protease quasispecies influence responsiveness to treatment with pegylated interferon plus ribavirin in HCV/HIV-coinfected patients.

Aparicio E, Franco S, Parera M, Andrés C, Tural C, Clotet B, Martínez MA.

J Virol. 2011 Jun;85(12):5961-9. doi: 10.1128/JVI.00308-11. Epub 2011 Apr 6.


Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates.

López-Labrador FX, Moya A, Gonzàlez-Candelas F.

Antivir Ther. 2008;13(4):481-94.


Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.

Morikawa K, Gouttenoire J, Hernandez C, Dao Thi VL, Tran HT, Lange CM, Dill MT, Heim MH, Donzé O, Penin F, Quadroni M, Moradpour D.

Hepatology. 2014 Feb;59(2):423-33. doi: 10.1002/hep.26671. Epub 2013 Dec 18.


In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile.

Martin MM, Condotta SA, Fenn J, Olmstead AD, Jean F.

Biol Chem. 2011 Oct;392(10):927-35. doi: 10.1515/BC.2011.076. Epub 2011 Jul 13.


Development of robust in vitro serine protease assay based on recombinant Pakistani HCV NS3-4A protease.

Fatima K, Tahir M, Qadri I.

Virus Res. 2011 Sep;160(1-2):230-7. doi: 10.1016/j.virusres.2011.06.020. Epub 2011 Jul 2.


Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors.

Li YP, Ramirez S, Humes D, Jensen SB, Gottwein JM, Bukh J.

Gastroenterology. 2014 Mar;146(3):812-821.e4. doi: 10.1053/j.gastro.2013.11.009. Epub 2013 Nov 18.


Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.

Horner SM, Park HS, Gale M Jr.

J Virol. 2012 Mar;86(6):3112-20. doi: 10.1128/JVI.06727-11. Epub 2012 Jan 11.


NS3-4A of hepatitis C virus is a chymotrypsin-like protease.

Hahm B, Han DS, Back SH, Song OK, Cho MJ, Kim CJ, Shimotohno K, Jang SK.

J Virol. 1995 Apr;69(4):2534-9.


A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target.

Schiering N, D'Arcy A, Villard F, Simic O, Kamke M, Monnet G, Hassiepen U, Svergun DI, Pulfer R, Eder J, Raman P, Bodendorf U.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21052-6. doi: 10.1073/pnas.1110534108. Epub 2011 Dec 12.


Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A Protease Activity.

Yao M, Lu X, Lei Y, Yang J, Zhao H, Qiao Q, Han P, Xu Z, Yin W.

PLoS One. 2016 Mar 4;11(3):e0150894. doi: 10.1371/journal.pone.0150894. eCollection 2016.


Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.

Hiscott J, Lacoste J, Lin R.

Biochem Pharmacol. 2006 Nov 30;72(11):1477-84. Epub 2006 Jul 31.


Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system.

Hong Z, Ferrari E, Wright-Minogue J, Chase R, Risano C, Seelig G, Lee CG, Kwong AD.

J Virol. 1996 Jul;70(7):4261-8.

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