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In utero valproate exposure and autism: long suspected, finally proven.

Harden CL.

Epilepsy Curr. 2013 Nov;13(6):282-4. doi: 10.5698/1535-7597-13.6.282. No abstract available.


Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.

Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M.

JAMA. 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270.


In utero antiepileptic drug exposure: fetal death and malformations.

Meador KJ, Baker GA, Finnell RH, Kalayjian LA, Liporace JD, Loring DW, Mawer G, Pennell PB, Smith JC, Wolff MC; NEAD Study Group..

Neurology. 2006 Aug 8;67(3):407-12.


Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy.

Wood AG, Nadebaum C, Anderson V, Reutens D, Barton S, O'Brien TJ, Vajda F.

Epilepsia. 2015 Jul;56(7):1047-55. doi: 10.1111/epi.13007. Epub 2015 May 11.


Pregnancy outcome after in utero exposure to valproate : evidence of dose relationship in teratogenic effect.

Diav-Citrin O, Shechtman S, Bar-Oz B, Cantrell D, Arnon J, Ornoy A.

CNS Drugs. 2008;22(4):325-34.


Sensory and motor characterization in the postnatal valproate rat model of autism.

Reynolds S, Millette A, Devine DP.

Dev Neurosci. 2012;34(2-3):258-67. Epub 2012 May 24.


Children exposed to valproate in utero--population based evaluation of risks and confounding factors for long-term neurocognitive development.

Eriksson K, Viinikainen K, Mönkkönen A, Aikiä M, Nieminen P, Heinonen S, Kälviäinen R.

Epilepsy Res. 2005 Jul;65(3):189-200.


Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.

Jacob J, Ribes V, Moore S, Constable SC, Sasai N, Gerety SS, Martin DJ, Sergeant CP, Wilkinson DG, Briscoe J.

Dis Model Mech. 2014 Jan;7(1):107-17. doi: 10.1242/dmm.013219. Epub 2013 Oct 17.


Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.

Ebbesen F, Joergensen A, Hoseth E, Kaad PH, Moeller M, Holsteen V, Rix M.

Arch Dis Child Fetal Neonatal Ed. 2000 Sep;83(2):F124-9.


Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.

Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group..

N Engl J Med. 2009 Apr 16;360(16):1597-605. doi: 10.1056/NEJMoa0803531.


In utero exposure to toxic air pollutants and risk of childhood autism.

von Ehrenstein OS, Aralis H, Cockburn M, Ritz B.

Epidemiology. 2014 Nov;25(6):851-8. doi: 10.1097/EDE.0000000000000150.


The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children.

Viinikainen K, Eriksson K, Mönkkönen A, Aikiä M, Nieminen P, Heinonen S, Kälviäinen R.

Epilepsy Behav. 2006 Dec;9(4):636-40. Epub 2006 Oct 16.


Valproate and the risk for congenital malformations: Is formulation and dosage regime important?

Mawhinney E, Campbell J, Craig J, Russell A, Smithson W, Parsons L, Robertson I, Irwin B, Morrison P, Liggan B, Delanty N, Hunt S, Morrow J.

Seizure. 2012 Apr;21(3):215-8. doi: 10.1016/j.seizure.2012.01.005. Epub 2012 Feb 23.


Child development following in utero exposure: levetiracetam vs sodium valproate.

Shallcross R, Bromley RL, Irwin B, Bonnett LJ, Morrow J, Baker GA; Liverpool Manchester Neurodevelopment Group.; UK Epilepsy and Pregnancy Register..

Neurology. 2011 Jan 25;76(4):383-9. doi: 10.1212/WNL.0b013e3182088297.


Adaptation of postimplantation embryos to culture: membrane lipid synthesis and response to valproate.

Brown NA, Clarke DO, McCarthy A.

Reprod Toxicol. 1991;5(3):245-53.


Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice.

Moldrich RX, Leanage G, She D, Dolan-Evans E, Nelson M, Reza N, Reutens DC.

Behav Brain Res. 2013 Nov 15;257:253-64. doi: 10.1016/j.bbr.2013.09.049. Epub 2013 Oct 5.


Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.

Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, Morrison PJ, Liggan B, Irwin B, Delanty N, Hunt SJ, Craig J, Morrow J.

J Neurol Neurosurg Psychiatry. 2014 Sep;85(9):1029-34. doi: 10.1136/jnnp-2013-306318. Epub 2014 Jan 20.


A novel automated behavioral test battery assessing cognitive rigidity in two genetic mouse models of autism.

Puścian A, Lęski S, Górkiewicz T, Meyza K, Lipp HP, Knapska E.

Front Behav Neurosci. 2014 Apr 29;8:140. doi: 10.3389/fnbeh.2014.00140. eCollection 2014.


Pregnancy and epilepsy.

Harden CL.

Continuum (Minneap Minn). 2014 Feb;20(1 Neurology of Pregnancy):60-79. doi: 10.1212/ Review.


A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate.

Wagner GC, Reuhl KR, Cheh M, McRae P, Halladay AK.

J Autism Dev Disord. 2006 Aug;36(6):779-93.


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