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Items: 1 to 20 of 224

1.

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, Wang WC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):279-84. doi: 10.1073/pnas.1311249111. Epub 2013 Dec 16.

2.

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation.

Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, Simmet T, Seufferlein T.

Mol Cancer. 2016 Jan 6;15:3. doi: 10.1186/s12943-015-0490-2.

3.

GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.

Li Z, Wang Y, Newton IP, Zhang L, Ji P, Li Z.

Cell Signal. 2015 Jun;27(6):1237-45. doi: 10.1016/j.cellsig.2015.02.030. Epub 2015 Mar 5.

PMID:
25748049
4.

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P.

Oncotarget. 2015 Sep 15;6(27):24061-74.

5.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL.

Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.

6.

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.

Mol Cell. 2012 Dec 14;48(5):771-84. doi: 10.1016/j.molcel.2012.09.028. Epub 2012 Nov 1.

7.

Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.

Dong T, Yan Y, Chai H, Chen S, Xiong X, Sun D, Yu Y, Deng L, Cheng F.

Biomed Pharmacother. 2015 Feb;69:277-84. doi: 10.1016/j.biopha.2014.12.010. Epub 2014 Dec 19.

PMID:
25661370
8.

PKM2 contributes to cancer metabolism.

Wong N, Ojo D, Yan J, Tang D.

Cancer Lett. 2015 Jan 28;356(2 Pt A):184-91. doi: 10.1016/j.canlet.2014.01.031. Epub 2014 Feb 4. Review.

PMID:
24508027
9.

PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis.

Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV.

FASEB J. 2017 May 11. pii: fj.201601291R. doi: 10.1096/fj.201601291R. [Epub ahead of print]

PMID:
28495754
10.

ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2.

Lee KM, Nam K, Oh S, Lim J, Lee T, Shin I.

Cell Signal. 2015 Feb;27(2):228-35. doi: 10.1016/j.cellsig.2014.11.004. Epub 2014 Nov 11.

PMID:
25446258
11.

IGF1 regulates PKM2 function through Akt phosphorylation.

Salani B, Ravera S, Amaro A, Salis A, Passalacqua M, Millo E, Damonte G, Marini C, Pfeffer U, Sambuceti G, Cordera R, Maggi D.

Cell Cycle. 2015;14(10):1559-67. doi: 10.1080/15384101.2015.1026490.

12.

PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop.

Luan W, Wang Y, Chen X, Shi Y, Wang J, Zhang J, Qian J, Li R, Tao T, Wei W, Hu Q, Liu N, You Y.

Oncotarget. 2015 May 30;6(15):13006-18.

13.

The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells.

He G, Jiang Y, Zhang B, Wu G.

Asia Pac J Clin Nutr. 2014;23(1):174-80. doi: 10.6133/apjcn.2014.23.1.14.

14.

Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue.

Kachel P, Trojanowicz B, Sekulla C, Prenzel H, Dralle H, Hoang-Vu C.

BMC Cancer. 2015 Mar 18;15:140. doi: 10.1186/s12885-015-1135-y.

15.

Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms.

Liu J, Wu N, Ma L, Liu M, Liu G, Zhang Y, Lin X.

PLoS One. 2014 Mar 13;9(3):e91606. doi: 10.1371/journal.pone.0091606. eCollection 2014.

16.

The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.

Zhao CB, Shi L, Pu HH, Zhang QY.

Pathol Oncol Res. 2017 Jan;23(1):47-53. doi: 10.1007/s12253-016-0076-3. Epub 2016 Jun 24.

PMID:
27342248
17.

Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways.

Kumar S, Donti TR, Agnihotri N, Mehta K.

Int J Cancer. 2014 Jun 15;134(12):2798-807. doi: 10.1002/ijc.28623. Epub 2014 Jan 30.

18.

Emerging roles of PKM2 in cell metabolism and cancer progression.

Luo W, Semenza GL.

Trends Endocrinol Metab. 2012 Nov;23(11):560-6. doi: 10.1016/j.tem.2012.06.010. Epub 2012 Jul 21. Review.

19.

Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells.

Jung Y, Jang YJ, Kang MH, Park YS, Oh SJ, Lee DC, Xie Z, Yoo HS, Park KC, Yeom YI.

Mol Cells. 2013 Apr;35(4):335-41. doi: 10.1007/s10059-013-2319-4. Epub 2013 Mar 18.

20.

Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ.

J Biol Chem. 2016 Jul 29;291(31):16011-23. doi: 10.1074/jbc.M115.698902. Epub 2016 Jun 1.

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