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Items: 1 to 20 of 102

1.

Reductions in serum IGF-1 during aging impair health span.

Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S.

Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30.

2.

A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.

Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

Minerva Endocrinol. 2002 Dec;27(4):299-311. Review.

PMID:
12511852
3.

Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.

Courtland HW, Sun H, Beth-On M, Wu Y, Elis S, Rosen CJ, Yakar S.

J Bone Miner Res. 2011 Apr;26(4):761-8. doi: 10.1002/jbmr.265.

4.

Mechanisms of thyroid hormone action on the insulin-like growth factor system: all thyroid hormone effects are not growth hormone mediated.

Näntö-Salonen K, Muller HL, Hoffman AR, Vu TH, Rosenfeld RG.

Endocrinology. 1993 Feb;132(2):781-8.

PMID:
7678799
5.
7.

Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.

PMID:
15769793
8.

Effects of growth hormone and insulin-like growth factor-1 on hepatocyte antioxidative enzymes.

Brown-Borg HM, Rakoczy SG, Romanick MA, Kennedy MA.

Exp Biol Med (Maywood). 2002 Feb;227(2):94-104.

PMID:
11815672
9.

Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.

Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ.

Growth Horm IGF Res. 2008 Dec;18(6):455-71. doi: 10.1016/j.ghir.2008.05.005. Epub 2008 Aug 16. Review.

10.

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

Diabetes. 2001 May;50(5):1110-8.

11.

IGF-I regulates the age-dependent signaling peptide humanin.

Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P.

Aging Cell. 2014 Oct;13(5):958-61. doi: 10.1111/acel.12243. Epub 2014 Jul 18.

12.

A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.

Carter CS, Ramsey MM, Sonntag WE.

Trends Genet. 2002 Jun;18(6):295-301. Review.

PMID:
12044358
13.

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner.

Courtland HW, Elis S, Wu Y, Sun H, Rosen CJ, Jepsen KJ, Yakar S.

PLoS One. 2011 Mar 18;6(3):e14762. doi: 10.1371/journal.pone.0014762.

14.

Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.

15.

Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms.

Mohan S, Richman C, Guo R, Amaar Y, Donahue LR, Wergedal J, Baylink DJ.

Endocrinology. 2003 Mar;144(3):929-36.

16.

Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.

Xu X, Hueckstaedt LK, Ren J.

J Hepatol. 2013 Aug;59(2):308-17. doi: 10.1016/j.jhep.2013.03.037. Epub 2013 Apr 11.

PMID:
23583271
17.

The GH/IGF-1 axis in ageing and longevity.

Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ.

Nat Rev Endocrinol. 2013 Jun;9(6):366-376. doi: 10.1038/nrendo.2013.67. Epub 2013 Apr 16. Review.

18.
19.

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P.

Cancer Res. 2008 May 1;68(9):3342-9. doi: 10.1158/0008-5472.CAN-07-3165.

20.

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.

Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M.

Endocrinology. 2005 Jul;146(7):2920-32. Epub 2005 Mar 24.

PMID:
15790724

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